Synthesis and Molecular Structure of 1-(3,4-Dimethoxy)-phenethyl-3- 3epoxypropyl-5-cyano-6-methyluracil

Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (10): 1107-1110. Previous Articles Next Articles

1-(3,4-二甲氧基）苯乙基-3-环氧丙基-5-氰基-6-甲基脲嘧啶的合成及晶体结构

张俊琪;王礼琛

中国药科大学有机化学教研室

发布日期:2003-10-25

Synthesis and Molecular Structure of 1-(3,4-Dimethoxy)-phenethyl-3- 3epoxypropyl-5-cyano-6-methyluracil

Zhang Junqi;Wang Lichen

Deparment of organic Chemistry, China Pharmaceutical University

Published:2003-10-25

Abstract

The title compound 1-(3,4-dimethoxy)phenethyl-3-epoxypropyl-5-cyano- 6-methyluracil has been synthesized by the reaction of 1-(3,4-dimethoxy) phenethyl-5-cyano-6-methyluracil in NaOH solution with 1-chloro-2,3- epoxypropane and its structure was determined by single-crystal X-ray diffraction study. The crystal is monoclinic system, space group P2_1/a with a = 1.09(10) nm, 6 = 1.43(10) nm, c = 1.20(8) nm, 7=1.868 nm~3, Z = 4, D_c= 1.32 Mg/m~3, F(000) = 784. On the basis of spectral analysis, the structure of by-product was identified.

Key words: URACIL P, EPOXYCHLOROPROPANE, CRYSTAL STRUCTURE, XRD, STRUCTURE CHARACTERISTICS

CLC Number:

O621

Cite this article

Zhang Junqi;Wang Lichen. Synthesis and Molecular Structure of 1-(3,4-Dimethoxy)-phenethyl-3- 3epoxypropyl-5-cyano-6-methyluracil[J]. Chin. J. Org. Chem., 2003, 23(10): 1107-1110.

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1-(3,4-二甲氧基）苯乙基-3-环氧丙基-5-氰基-6-甲基脲嘧啶的合成及晶体结构

Synthesis and Molecular Structure of 1-(3,4-Dimethoxy)-phenethyl-3- 3epoxypropyl-5-cyano-6-methyluracil

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