Vibrational Circular Dichroism: A New Tool for the Determination of Absolute Configuration of Chiral Molecules

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (06): 848-857. Previous Articles Next Articles

Review

振动圆二色谱: 一种确定手性分子绝对构型的新方法

甘礼社; 周长新*

(浙江大学药学院现代中药研究所杭州 310058)

收稿日期:2008-09-17 修回日期:2008-10-22 发布日期:2009-06-20
通讯作者: 周长新

Vibrational Circular Dichroism: A New Tool for the Determination of Absolute Configuration of Chiral Molecules

Gan, Lishe; Zhou, Changxin*

(Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058)

Received:2008-09-17 Revised:2008-10-22 Published:2009-06-20
Contact: Zhou, Changxin

Abstract

The determination of the absolute configuration (AC) of chiral molecules is an important issue in organic chemistry. Vibrational circular dichroism (VCD) is a useful technology to measure the circular dichroism of chiral molecules in the IR region, which remarkably expands the application of circular dichroism to the determination of AC. The AC of chiral molecules can be determined by comparison of the experimental VCD spectra with the theoretical VCD ones obtained on the basis of quantum chemical calculations.

Key words: chiral molecule, absolute configuration, quantum chemical calculation, vibrational circular dichroism

Cite this article

Gan, Lishe; Zhou, Changxin*. Vibrational Circular Dichroism: A New Tool for the Determination of Absolute Configuration of Chiral Molecules[J]. Chin. J. Org. Chem., 2009, 29(06): 848-857.

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振动圆二色谱: 一种确定手性分子绝对构型的新方法

Vibrational Circular Dichroism: A New Tool for the Determination of Absolute Configuration of Chiral Molecules

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