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Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (9): 1450-1456. Previous Articles Next Articles
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朱 华a,b 黄立梁a,b 张春春a,b 许 嘉a 沈玉梅*,a
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Zhu, Huaa,b Huang, Lilianga,b Zhang, Chunchuna,b Xu, Jiaa Shen, Yumei*,a
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Starting from 4,4’-dihydroxybenzophenone, three kinds of cyclofenil analogues were prepared by Mcmurry coupling. Under optimized conditions a series of cyclofenil rhenium(I) tricarbonyl conjugates were prepared as molecular probe precursors of estrogen receptor β by ω-bromoalkylation and subsequent nucleophilic substitution. The study provides a useful assessment of the stage of the breast cancer by imaging ERβ with the SPECT (single photon emission computed tomography) technique. The structures of final products and the intermediates were confirmed by IR, 1H NMR, 13C NMR, HRMS techniques or elemental analysis.
Key words: rhenium tricarbonyl, breast cancer, cyclofenil
Zhu, Huaa,b Huang, Lilianga,b Zhang, Chunchuna,b Xu, Jiaa Shen, Yumei*,a. Synthesis of Cyclofenil Rhenium Tricarbonyl Conjugates[J]. Chin. J. Org. Chem., 2009, 29(9): 1450-1456.
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