Synthesis and Biological Activity of 8-Piperazinomethylflavone  Derivatives

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (9): 1445-1449. Previous Articles Next Articles

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8-黄酮哌嗪衍生物的合成及生理活性研究

郑梅花a 甘莹b 谢松强b 王超杰a,b 赵瑾*,a,b

(a河南大学化学化工学院开封 475004)
(b河南大学天然药物与免疫工程重点实验室开封 475004)

收稿日期:2008-12-31 修回日期:2009-04-24 发布日期:2009-12-30
通讯作者: 赵瑾

Synthesis and Biological Activity of 8-Piperazinomethylflavone Derivatives

Zheng, Meihua ^a Gan, Ying ^b Xie, Songqiang ^b Wang, Chaojie ^a,b Zhao, Jin ^*,a,b

(^a College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004)
(^b Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng 475004)

Received:2008-12-31 Revised:2009-04-24 Published:2009-12-30
Contact: Zhao, Jin

Abstract

Four 8-piperazinomethylflavone and four 8-flavonemethyl-polyisoprenylpiperazine derivatives were designed, synthesized, and structurally were confirmed by 1H NMR, ESI-MS techniques and elemental analysis. The prelimilary antitumor activity was evaluated on Bel-7402 and K562 cell lines by MTT assay. The results demonstrated that 8-flavonemethyl-piperazines and N,N-di(8-flavonemethyl)piperazines did not exhibit antitumor activity. However, two N-(8-flavonemethyl)-N’-polyisoprenylpiperazines possessed better antitumor activity against K562 cell lines than prior N,N-bis(8-flavonemethyl)geranylamine (1).

Key words: synthesis, biological activity, flavone derivative

Cite this article

Zheng, Meihua ^a Gan, Ying ^b Xie, Songqiang ^b Wang, Chaojie ^a,b Zhao, Jin ^*,a,b. Synthesis and Biological Activity of 8-Piperazinomethylflavone Derivatives[J]. Chin. J. Org. Chem., 2009, 29(9): 1445-1449.

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8-黄酮哌嗪衍生物的合成及生理活性研究

Synthesis and Biological Activity of 8-Piperazinomethylflavone Derivatives

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