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Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (12): 1605-1608. Previous Articles Next Articles
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金文虎,金晶,冀亚飞*
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JIN Wen-Hu, JIN Jing, JI Ya-Fei*
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2,3,4,5-Tetramethoxytoluene was brominated to prepare 6-bromo-2,3,4,5-tetramethoxytoluene whose Grignard reagent was condensed with (E)-4-cholro-2-methyl-1-phenylsulfonyl-2-butene in the presence of cuprous iodide to obtain the intermediate 6-(E-3'-methyl-4'-phenylsulfonyl-2'-butenyl)-2,3,4,5- tetramethoxytoluene, from which coenzyme Q10 was finally achieved via condensation with solanesyl bromide, desulfonylation and oxidation with an overall yield of 31.3% based on 2,3,4,5-tetramethoxytoluene.
Key words: solanesol, ammonium cerium(IV) nitrate, coenzyme Q10, 2,3,4,5-tetramethoxytoluene
JIN Wen-Hu, JIN Jing, JI Ya-Fei*. Synthesis of Coenzyme Q10[J]. Chin. J. Org. Chem., 2007, 27(12): 1605-1608.
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