Recent Progress in Asymmetric 1,4-Conjugate Addition ofGrignard Reagents

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (2): 181-186. Previous Articles Next Articles

Review

铜络合物催化的格氏试剂不对称1,4-共轭加成反应研究进展

汪顺义，纪顺俊*

(苏州大学化学化工学院江苏省有机合成重点实验室苏州 215123)

收稿日期:2007-01-16 修回日期:2007-05-21 发布日期:2008-02-01
通讯作者: 纪顺俊

Recent Progress in Asymmetric 1,4-Conjugate Addition ofGrignard Reagents

WANG Shun-Yi,JI Shun-Jun*

(Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineer-ing,
Suzhou University, Suzhou 215123)

Received:2007-01-16 Revised:2007-05-21 Published:2008-02-01
Contact: JI Shun-Jun

Abstract

The copper-catalyzed conjugate addition of organometallic reagents to α,β-unsaturated car-bonyl compounds is one of the most versatile synthetic methods for the construction of C—C bonds. This review summarizes recent advance in the enantioselectivity of 1,4-conjugate addition of Grignard reagents to α,β-unsaturated carbonyl compounds.

Key words: enantioselective, Grignard reagent, 1,4-conjugate addition, chiral catalyst, copper-complex

Cite this article

WANG Shun-Yi,JI Shun-Jun*. Recent Progress in Asymmetric 1,4-Conjugate Addition ofGrignard Reagents[J]. Chin. J. Org. Chem., 2008, 28(2): 181-186.

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铜络合物催化的格氏试剂不对称1,4-共轭加成反应研究进展

Recent Progress in Asymmetric 1,4-Conjugate Addition ofGrignard Reagents

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