Bis-hydroxymethylation and bis-imidazolylmethylation of estrogens

Chin. J. Org. Chem. ›› 1992, Vol. 12 ›› Issue (4): 396-399. Previous Articles Next Articles

Original Articles

雌甾的双羟甲基化和双咪唑甲基化反应

谢如刚;邬家明;张祝君;韩明成

四川大学化学系

发布日期:1992-08-25

Bis-hydroxymethylation and bis-imidazolylmethylation of estrogens

XIE RUGANG;WU JIAMING;ZHANG ZHUJUN;HAN MINGCHENG

Published:1992-08-25

Abstract

Direct bis-hydroxymethylation and bis-imidazolylmethylation of steroidal estrogens were studied. Estradiol, 17a-ethynylestradiol, estrone or estrone 17-ethylene ketal was treated with paraformaldehyde resp., at 50~55?in dioxane in the presence of solid NaOH to give the corresponding 2,4-bis(hydroxymethyl)estrogens. Estrogens were treated with paraformaldehyde and imidazole at 130~140? or via bis-hydroxymethylation then with imidazole to give the corresponding 2,4-bis(imidazolylmethyl)estrogens.

Key words: IMIDAZOLE P, ETHINYLOESTRADIOLUM, SODIUM HYDROXIDE, CARBINOL GROUP, POLYOXYMETHYLENE, RESPONSIBLE, ETHYLENE KETAL

CLC Number:

O629

Cite this article

XIE RUGANG;WU JIAMING;ZHANG ZHUJUN;HAN MINGCHENG. Bis-hydroxymethylation and bis-imidazolylmethylation of estrogens[J]. Chin. J. Org. Chem., 1992, 12(4): 396-399.

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雌甾的双羟甲基化和双咪唑甲基化反应

Bis-hydroxymethylation and bis-imidazolylmethylation of estrogens

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