Synthesis of 2-aroylamino-5-(5-benzyltetrazol-2-methene) - 1, 3, 4 -thiadiazoles

Chin. J. Org. Chem. ›› 1992, Vol. 12 ›› Issue (4): 392-396. Previous Articles Next Articles

Original Articles

2-芳酰氨基-5-(5-苄基四唑-2-亚甲基)-1,3,4-噻二唑的合成

冯小明;陈荣;杨晓兰

西南师范大学化学系

发布日期:1992-08-25

Synthesis of 2-aroylamino-5-(5-benzyltetrazol-2-methene) - 1, 3, 4 -thiadiazoles

FENG XIAOMING;CHEN RONG;YANG XIAOLAN

Published:1992-08-25

Abstract

Title compoundsI (R = substituted Ph, PHCH:CH; a-naphthylmethyl) were synthesized by cyclization f 1-(5-benzyltetrazol-2-ylacetyl)-4-aroylthiosemicarbazides II with concentrated H2SO4 at 0? I were screened for their antibacterial activity against Escherichia coli and Bacillus subtilis at 2.0 ?10-4 mol.L-1. The results showed that I (R = 4-CLC6H4, 3-ClC6H4, 4-BrC6H4) exhibited strong inhibiting effect on Escherichia coli and Bacillus subtilis.

Key words: TETRAZOLE, BENZAMIDE P, PLANT GROWTH REGULATORS, NMR SPECTROMETRY, INFRARED SPECTROPHOTOMETRY, THIADIAZOLE P, MASS SPECTROGRAPHY, ELEMENTAL ANALYSIS, BENZYL GROUP, SULFOCARBAMIDES

CLC Number:

R914

Cite this article

FENG XIAOMING;CHEN RONG;YANG XIAOLAN. Synthesis of 2-aroylamino-5-(5-benzyltetrazol-2-methene) - 1, 3, 4 -thiadiazoles[J]. Chin. J. Org. Chem., 1992, 12(4): 392-396.

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2-芳酰氨基-5-(5-苄基四唑-2-亚甲基)-1,3,4-噻二唑的合成

Synthesis of 2-aroylamino-5-(5-benzyltetrazol-2-methene) - 1, 3, 4 -thiadiazoles

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