Synthesis and Biological Activities of 2-(Amino/aroxy)-5,8,9-trimethylthieno[3',2'∶5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (04): 632-637. Previous Articles Next Articles

Original Articles

2-胺基(芳氧基)-5,8,9-三甲基噻吩并吡啶并[4,3-d]嘧啶-4(3H)-酮的合成和生物活性

刘建超*^,a,b，贺红武*^,a，丁明武^a

(^a华中师范大学化学学院农药与化学生物学教育部重点实验室武汉 430079)
(^b中南大学化学化工学院长沙 410083)

收稿日期:2007-08-01 修回日期:2007-09-12 发布日期:2008-04-17
通讯作者: 贺红武

Synthesis and Biological Activities of 2-(Amino/aroxy)-5,8,9-trimethylthieno[3',2'∶5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives

LIU Jian-Chao*^,a,b,HE Hong-Wu*^,a,DING Ming-Wu^a

(^aKey Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemis-try,
Central China Normal University, Wuhan 430079)
(^b College of Chemistry and Chemical Engineering, Central South University, Changsha 410083)

Received:2007-08-01 Revised:2007-09-12 Published:2008-04-17
Contact: HE Hong-Wu*<

Abstract

A series of new 2-(amino/aroxy)-5,8,9-trimethylthieno[3',2'∶5,6]pyrido[4,3-d]pyrimidin- 4(3H)-one derivatives have been designed and synthesized via an aza-Wittig reaction and structually confirmed by elemental analysis, IR, ¹H NMR, EI-MS spectra, and compound II-1 by X-ray diffraction analysis. Their biological activities were also researched and many of them showed good fungicidal and herbicidal activities to some extent.

Key words: pyrido[4,3-d]pyrimidine, aza-Wittig reaction, fungicidal activity, herbicidal activity

Cite this article

LIU Jian-Chao*^,a,b,HE Hong-Wu*^,a,DING Ming-Wu^a. Synthesis and Biological Activities of 2-(Amino/aroxy)-5,8,9-trimethylthieno[3',2'∶5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives[J]. Chin. J. Org. Chem., 2008, 28(04): 632-637.

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2-胺基(芳氧基)-5,8,9-三甲基噻吩并吡啶并[4,3-d]嘧啶-4(3H)-酮的合成和生物活性

Synthesis and Biological Activities of 2-(Amino/aroxy)-5,8,9-trimethylthieno[3',2'∶5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives

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