Electrophilic Reaction of Methyl Pyropheophorbide-a at 20-meso-1-Position

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (04): 693-699. Previous Articles Next Articles

Original Articles

焦脱镁叶绿酸-a甲酯20-meso-1-位的亲电取代反应

王进军^a,b，李家柱^b,c，殷军港^b，刘永军*^,a

(^a中国科学院西北高原研究所西宁 810001)
(^b烟台大学化学生物理工学院烟台 264005)
(^c烟台大学药学院烟台 264005)

收稿日期:2007-04-13 修回日期:2007-09-10 发布日期:2008-04-17
通讯作者: 刘永军

Electrophilic Reaction of Methyl Pyropheophorbide-a at 20-meso-1-Position

WANG Jin-Jun^a,b,LI Jia-Zhu^b,c,YIN Jun-Gang^b,LIU Yong-Jun*^,a

(^a Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001)
(^b Science and Engineering College of Chemistry and Biology, Yantai Univer-sity, Yantai 264005)
(^c College of Pharmacy, Yantai University, Yantai 264005)

Received:2007-04-13 Revised:2007-09-10 Published:2008-04-17
Contact: LIU Yong-Jun

Abstract

By using the electrophilic reaction of methyl pyropheophorbide-a with various electrophilic reagents, the new 20-meso-(nitro and halogen)-substituted pyropheophorbide derivatives were obtained, the structures of which were characterized by UV, IR, ¹H NMR spectra and elemental analysis. The aromaticity and reactive activity of the chlorin ring in the chlorophyll-a derivatives were discussed and the possible mechanism for the electrophilic reaction was tentatively proposed as well.

Key words: electrophilic substitution reaction, methyl pyropheophorbide-a, chlorophyll-a derivative, photodynamic therapy

Cite this article

WANG Jin-Jun,b,LI Jia-Zhu^b,c,YIN Jun-Gang^b,LIU Yong-Jun*^,a. Electrophilic Reaction of Methyl Pyropheophorbide-a at 20-meso-1-Position[J]. Chin. J. Org. Chem., 2008, 28(04): 693-699.

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焦脱镁叶绿酸-a甲酯20-meso-1-位的亲电取代反应

Electrophilic Reaction of Methyl Pyropheophorbide-a at 20-meso-1-Position

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