Synthesis and Characterization of Rhenium Tricarbonyl Core  Complexes of Bile Acid Derivatives

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (03): 396-402. Previous Articles Next Articles

Original Articles

胆汁酸衍生物三羰基铼核配合物的合成与表征

黄立梁^a,b ; 朱华^a,b; 刘贵锋^a,b; 许嘉^a ; 沈玉梅^*,a

(a中国科学院上海应用物理研究所放射性药物研究中心上海 201800)
(b中国科学院研究生院北京 100049)

收稿日期:2008-07-17 修回日期:2008-09-16 发布日期:2009-03-20
通讯作者: 沈玉梅

Synthesis and Characterization of Rhenium Tricarbonyl Core Complexes of Bile Acid Derivatives

Huang, Liliang ^a,b; Zhu, Hua ^a,b; Liu, Guifeng ^a,b; Xu, Jia ^a; Shen, Yumei ^*,a

(a Research Center of Radiopharmaceuticals, Shanghai Institute of Applied Physics,
Chinese Academy of Sciences, Shanghai 201800)
(b Graduate School of the Chinese Academy of Sciences, Beijing 100049)

Received:2008-07-17 Revised:2008-09-16 Published:2009-03-20
Contact: Shen, Yumei

Abstract

A series of novel bile acid derivatives as potential hepato-biliary and intestinal scintigraphy imaging SPECT (single photon emission computed tomography) tracers were prepared from bile acids by es-terification, aminolysis of esters and alkylation of amino groups. The procedure is simple and easy to be car-ried out with high yields. Their structures have been confirmed by IR, 1H NMR, 13C NMR, HRMS tech-niques and elemental analysis. These results provide some opportunities for further research on radiophar-maceuticals based on bile acids.

Key words: chenodeoxycholic acid, tridentate pyridine ligand, rhenium tricarbonyl, bile acid

Cite this article

Huang, Liliang ^a,b; Zhu, Hua ^a,b; Liu, Guifeng ^a,b; Xu, Jia ^a; Shen, Yumei ^*,a. Synthesis and Characterization of Rhenium Tricarbonyl Core Complexes of Bile Acid Derivatives[J]. Chin. J. Org. Chem., 2009, 29(03): 396-402.

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胆汁酸衍生物三羰基铼核配合物的合成与表征

Synthesis and Characterization of Rhenium Tricarbonyl Core Complexes of Bile Acid Derivatives

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