Synthesis of 6α- and 6β-Hydroxydeoxycholic Acid

doi:10.6023/cjoc202002008

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 2114-2119.DOI: 10.6023/cjoc202002008 Previous Articles Next Articles

6α和6β-羟基去氧胆酸的合成

牛伟, 肖丹, 程航, 徐亮

四川大学华西药学院天然药物系暨教育部靶向药物重点实验室成都 610041

收稿日期:2020-02-07 修回日期:2020-04-21 发布日期:2020-05-11
通讯作者: 徐亮 E-mail:liangxu@scu.edu.cn
基金资助:
国家自然科学基金（No.21871190）资助项目.

Synthesis of 6α- and 6β-Hydroxydeoxycholic Acid

Niu Wei, Xiao Dan, Cheng Hang, Xu Liang

Key Laboratory of Drug Targeting, Ministry of Education, Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu 610041

Received:2020-02-07 Revised:2020-04-21 Published:2020-05-11
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21871190).

1. 202114S.pdf(1127KB)

Abstract

6α- and 6β-hydroxydeoxycholic acids[DCA-6α-ol (6) and DCA-6β-ol (7)] are recently identified important tertiary bile acids derived from deoxycholic acid (3) in human liver. A rapid and robust synthesis of DCA-6α-ol (6) and DCA-6β-ol (7) from cholic acid (1) in 10 steps involing the key Mukaiyama aldol condensation, ozone oxidative cleavage and SmI₂ promoted reductive deoxygenation was conducted.

Key words: bile acid, 6α-hydroxydeoxycholic acid, 6β-hydroxydeoxycholic acid, synthesis

Cite this article

Niu Wei, Xiao Dan, Cheng Hang, Xu Liang. Synthesis of 6α- and 6β-Hydroxydeoxycholic Acid[J]. Chinese Journal of Organic Chemistry, 2020, 40(7): 2114-2119.

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6α和6β-羟基去氧胆酸的合成

Synthesis of 6α- and 6β-Hydroxydeoxycholic Acid

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