Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (06): 860-865. Previous Articles     Next Articles

Reports

系列单取代烷氧基-2-羟丙基-β-环糊精的合成与表征

张毅民*,张国栋,甘永江,苑珊,王虹   

  1. (天津大学化工学院 绿色合成与转化教育部重点实验室 天津 300072)
  • 收稿日期:2005-07-07 修回日期:2005-12-26 发布日期:2006-05-31
  • 通讯作者: 张毅民

Synthesis and Characterization of Monosubstituted 3-Alkyloxy-2-hydroxypropyl-β-cyclodextrins

ZHANG Yi-Min*,ZHANG Guo-Dong,GAN Yong-Jiang
YUAN Shan,WANG Hong   

  1. (Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072)
  • Received:2005-07-07 Revised:2005-12-26 Published:2006-05-31
  • Contact: ZHANG Yi-Min

Four intermediates of glycidyl ethers, namely ethyl glycidyl ether (1), propyl glycidyl ether (2), butyl glycidyl ether (3) and amyl glycidyl ether (4), were obtained through a phase-transfer catalytic methodology using acyclic alcohol and epichlorohydrin as raw materials. To choose 1.5% or 30% of sodium hydroxide solution as the environmental media, subsequent procedures were conducted with these glycidyl ethers and β-cyclodextrin. The products were isolated through a self packed silica gel column chromatography, and their chemical structures were proved to be the mono substituted 2-(3-alkyloxy-2-hydroxypropyl)- β-cyclodextrins (1a4a) and mono substituted 6-(3-alkyloxy-2-hydroxypropyl)-β-cyclodextrins (2b4b) by means of the TLC, IR, DSC, MS, 1H NMR and 13C NMR measurements.

Key words: glycidyl ether, epichlorohydrin, 3-alkyloxy-2-hydroxypropyl-β- cyclodextrin, β-cyclodextrin derivative