Synthesis of a Polymer(fiber)-Supported Chiral Amino Alcohol and Its Application to Enantioselective Addition of Diethylzinc to Benzaldehyde

Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (05): 718-722. Previous Articles Next Articles

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高分子(纤维)负载手性氨基醇的合成及其催化二乙基锌对苯甲醛的不对称加成

林昆华*^,1，曾庆彬¹，李明星¹，潘庆谊¹，宋毛平²，吴养洁²

(¹上海大学理学院化学系上海 200444)
(²郑州大学化学系郑州 450052)

收稿日期:2005-06-24 修回日期:2005-11-28 发布日期:2006-04-28
通讯作者: 林昆华

Synthesis of a Polymer(fiber)-Supported Chiral Amino Alcohol and Its Application to Enantioselective Addition of Diethylzinc to Benzaldehyde

LIN Kun-Hua*^,1,ZENG Qing-Bin¹,LI Ming-Xing¹,PAN Qing-Yi¹
SONG Mao-Ping²,WU Yang-Jie²

(¹ Department of Chemistry, Shanghai University, Shanghai 200444)
(² Department of Chemistry, Zhengzhou University, Zhengzhou 450052)

Received:2005-06-24 Revised:2005-11-28 Published:2006-04-28
Contact: LIN Kun-Hua

Abstract

A polymer(fiber)-supported chiral amino alcohol was synthesized and applied to the enantioselective addition of diethylzinc to benzaldehyde. Compared with the resin-supported chiral amino alcohol in the same reactive time, the fiber-supported amino alcohol could increase the yield and ee value by 34% and 9% respectively. This fiber-supported catalyst could be recycled more than 5 times. The reason why catalytic property was dropped down in recycle was proved to be the loss of catalyst by the analysis of their SEM photographs.

Key words: diethylzinc, benzaldehyde, enantioselective addition, polymer(fiber)-supported chiral amino alcohol

Cite this article

LIN Kun-Hua*^,1,ZENG Qing-Bin,LI Ming-Xing,PAN Qing-Yi
SONG Mao-Ping²,WU Yang-Jie². Synthesis of a Polymer(fiber)-Supported Chiral Amino Alcohol and Its Application to Enantioselective Addition of Diethylzinc to Benzaldehyde[J]. Chin. J. Org. Chem., 2006, 26(05): 718-722.

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高分子(纤维)负载手性氨基醇的合成及其催化二乙基锌对苯甲醛的不对称加成

Synthesis of a Polymer(fiber)-Supported Chiral Amino Alcohol and Its Application to Enantioselective Addition of Diethylzinc to Benzaldehyde

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