Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (07): 885-898.     Next Articles

Review

固载化试剂和催化剂及其在液相组合合成中的应用

张亮,刘刚*   

  1. (中国医学科学院中国协和医科大学药物研究所 北京 100050)
  • 收稿日期:2005-06-01 修回日期:2005-11-05 发布日期:2006-07-01
  • 通讯作者: 刘刚

Solid-Supported Reagents, Catalysts and Their Use toSolution Phase Synthesis

ZHANG Liang,LIU Gang*   

  1. (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050)
  • Received:2005-06-01 Revised:2005-11-05 Published:2006-07-01
  • Contact: LIU Gang

The parallel combinatorial solution phase synthesis was already greatly benefited from using solid-supported reagents, catalysts and scavengers in the past decade. Solidified reagents or catalysts could integrate the advantages of the solution phase synthesis and the convenience of the product isolation and purification of solid phase synthesis. This paper reviews the achievement in the single-step, multi-step combinatorial solution-phase synthesis using the solid-supported reagents and catalysts.

Key words: combinatorial synthesis, solid-supported catalyst, solution-phase synthesis, solid-supported reagent