Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases

doi:10.6023/cjoc201307012

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (12): 2469-2484.DOI: 10.6023/cjoc201307012 Previous Articles Next Articles

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植物聚酮合酶在合成“非天然小分子”中的应用

张乐^a, 王娟^a, 李彬^a, 高博闻^a, 王晓晖^a, 史社坡^a, 屠鹏飞^a,b

a 北京中医药大学中药现代研究中心北京 100029;
b 北京大学药学院天然药物及仿生药物国家重点实验室北京 100191

收稿日期:2013-07-12 修回日期:2013-08-08 发布日期:2013-08-21
通讯作者: 史社坡，屠鹏飞 E-mail:shishepo@163.com；pengfeitu@bjmu.edu.cn
基金资助:
教育部新世纪优秀人才支持计划(No. NCET-11-0604)、北京市自然科学基金(No. 5132022)资助项目.

Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases

Zhang Le^a, Wang Juan^a, Li Bin^a, Gao Bowen^a, Wang Xiaohui^a, Shi Shepo^a, Tu Pengfei^a,b

a Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029;
b State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191

Received:2013-07-12 Revised:2013-08-08 Published:2013-08-21
Supported by:
Project supported by the Trans-Century Training Program Foundation for the Talents of Humanities and Social Science by the State Education Commission (No. NCET-11-0604) and the Natural Science Foundation of Beijing (No. 5132022).

Plant polyketide synthases (PKSs) catalyze iterative decarboxylative condensations of malonyl units (Claisen-type C—C bond formation) with a CoA-linked starter molecule to produce linear chain polyketide intermediates. By Claisen, aldol cyclization, or lactonization, and aromatization, the linear chain polyketide intermediates produce varied unnatural small molecules. In this review, the functions of the known plant PKSs are summarized, and the catalytic mechanisms and applications of plant PKSs in the synthesis of unnatural small molecules are covered.

Key words: plant polyketide synthases, unnatural small molecules, combinatorial synthesis, combinatorial biosynthesis

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Zhang Le, Wang Juan, Li Bin, Gao Bowen, Wang Xiaohui, Shi Shepo, Tu Pengfei. Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases[J]. Chin. J. Org. Chem., 2013, 33(12): 2469-2484.

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植物聚酮合酶在合成“非天然小分子”中的应用

Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases

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