Synthesis and Characterization of Bis{2-[1-methyl-4-(1-methyl-4-ni-tropyrrole-2-acylimido)pyrrole-2-acylimido]ethyl}amine

Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (06): 831-834. Previous Articles Next Articles

Original Articles

二[1-甲基-4-(1-甲基-4-硝基吡咯-2-酰胺基)吡咯-2-酰胺基乙基]胺的合成与表征

周成勇^a,b，朱苗力¹，杨频*^,1

(¹山西大学分子科学研究所化学生物学与分子工程教育部重点实验室太原 030006)
(²山西长治学院生化系长治 046011)

收稿日期:2005-09-13 修回日期:2005-12-23 发布日期:2006-05-31
通讯作者: 杨频

Synthesis and Characterization of Bis{2-[1-methyl-4-(1-methyl-4-ni-tropyrrole-2-acylimido)pyrrole-2-acylimido]ethyl}amine

ZHOU Cheng-Yong^a,b,ZHU Miao-Li¹,YANG Pin*^,1

(¹Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Educa-tion,
Institute of Molecular Science, Shanxi University, Taiyuan 030006)
(²Department of Biochemistry, Changzhi College, Changzhi 046011)

Received:2005-09-13 Revised:2005-12-23 Published:2006-05-31
Contact: YANG Pin

Abstract

In this paper, the synthesis of a sort of symmetrical and parallel polyamide, bis{2-[1-methyl- 4-(1-methyl-4-nitropyrrole-2-acylimido)pyrrole-2-acylimido]ethyl}amine, was reported. The whole process was also simple and convenient without column chromatography with high yields. The target compound was anticipated to recognize DNA sequence specifically and cleave it at predetermined site.

Key words: polyamide, diethylenetriamine, pyrrole, recognition and cleavage of DNA, bis{2-[1-methyl-4-(1-methyl-4-nitropyrrole-2-acylimido)pyrrole-2-acylimido]ethyl}amine

Cite this article

ZHOU Cheng-Yong^a,b,ZHU Miao-Li,YANG Pin*^,1. Synthesis and Characterization of Bis{2-[1-methyl-4-(1-methyl-4-ni-tropyrrole-2-acylimido)pyrrole-2-acylimido]ethyl}amine[J]. Chin. J. Org. Chem., 2006, 26(06): 831-834.

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二[1-甲基-4-(1-甲基-4-硝基吡咯-2-酰胺基)吡咯-2-酰胺基乙基]胺的合成与表征

Synthesis and Characterization of Bis{2-[1-methyl-4-(1-methyl-4-ni-tropyrrole-2-acylimido)pyrrole-2-acylimido]ethyl}amine

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