The synthesis of 1,3-oxathiolane nucleoside derivatives was investigated. A series of novel 1,3-oxathiolane nucleoside derivatives, in which the bases have been replaced by pyridinone derivatives, were synthesized by the Vorbruggen coupling method using TMSOTf as the catalyst, and then deprotection or reduction reactions. Their antimicrobial activity was determined, showing that they had moderate activity against G+ microbial.

Key words: pyridinone, Vorbruggen coupling method, nucleoside derivative