Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (03): 465-468. Previous Articles     Next Articles

Notes

微波辅助1,4-迈克尔加成合成香豆素3-, 4-并六元杂环衍生物

严胜骄,林军*   

  1. (云南大学化学科学与工程学院 教育部自然资源药物化学重点实验室 昆明 650091)
  • 收稿日期:2009-05-31 修回日期:2009-09-30 发布日期:2010-03-28
  • 通讯作者: 严胜骄 E-mail:yanshengjiao@126.com
  • 基金资助:

    云南省自然科学基金

Microwave Assisted Synthesis of Coumarin[3,4-c] Six-membered Heterocyclic Derivatives via 1,4-Michael Addition Reaction

Yan Shengjiao,Lin Jun   

  1. (Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education,
    School of Chemical Science and Technology, Yunnan University, Kunming 650091)
  • Received:2009-05-31 Revised:2009-09-30 Published:2010-03-28
  • Contact: Sheng-Jiao Yan E-mail:yanshengjiao@126.com

A series of coumarin[3,4-c] six-membered heterocyclic derivatives were synthesized via 1,4-Michael addition, condensation and aromatization of coumarin and heterocyclic ketene aminals catalyzed by potassium hexamethyldisilazane (KHMDS) in dioxane under microwave irradiation. The reactions were completed in 20 min with 60%~87% yields, easy work-up and short reaction time.

Key words: coumarin, microwave, heterocyclic ketene aminal