Ligand-Free Pd(OAc)2 Catalyzed Heck Reaction under Air

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (03): 469-473. Previous Articles Next Articles

Notes

无配体、在空气下Pd(OAc)₂催化的Heck反应研究

陈为^a，于淼*^{,b，潘德林^c，焦宁*^,c}

(^a中国人民解放军军医进修学院北京 100853)
(^b中国人民解放军总医院放射诊断科北京 100853)
(^c北京大学药学院天然药物及仿生药物国家重点实验室北京 100191)

收稿日期:2010-01-16 修回日期:2010-02-28 发布日期:2010-03-28
通讯作者: 焦宁 E-mail:jiaoning@bjmu.edu.cn

Ligand-Free Pd(OAc)₂ Catalyzed Heck Reaction under Air

Chen Wei^a,Yu Miao*^{,b,Pan Delin^c,Jiao Ning*^,c}

(^aChinese PLA Postgraduate Medical School, Beijing 100853)
(^bDepartment of Radiology, Chinese PLA General Hospital, Beijing 100853)
(^cState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences,
Peking University, Beijing 100191)

Received:2010-01-16 Revised:2010-02-28 Published:2010-03-28
Contact: Ning Jiao E-mail:jiaoning@bjmu.edu.cn

Abstract

Ligand-free Pd(OAc)₂ catalyzed Heck reaction under air was studied in this work. Iodobenzene, bromobenzene and their derivatives reacted smoothly with different alkenes in the presence of palladium acetate. The reactions were conducted under air in the absence of ligand. The effect of base, additives, solvents and catalysts on this transformation was investigated. The optimized reaction conditions were approved as: Pd(OAc)₂ (5 mol%), Ag₂CO₃ (0.6 equiv.), reflux in benzene or toluene under air.

Key words: ligand-free, Pd-catalyzed, Heck reaction

Cite this article

CHEN Wei, XU Miao, BO De-Lin, JIAO Ning. Ligand-Free Pd(OAc)₂ Catalyzed Heck Reaction under Air[J]. Chin. J. Org. Chem., 2010, 30(03): 469-473.

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无配体、在空气下Pd(OAc)₂催化的Heck反应研究

Ligand-Free Pd(OAc)₂ Catalyzed Heck Reaction under Air

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无配体、在空气下Pd(OAc)2催化的Heck反应研究