Synthesis and Proliferative Effects on T Lymphocytes of Novel Thiazolidin-4-one Linked Pseudotrisaccharides

doi:10.6023/cjoc1111291

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (05): 943-948.DOI: 10.6023/cjoc1111291 Previous Articles Next Articles

Notes

噻唑烷-4-酮连假三糖的合成及其对T 淋巴细胞增殖活性研究

陈华^a, 高芳^a, 殷庆梅^a, 李春晓^b, 李娜^b, 孟明^b, 李小六^a

a 河北大学化学与环境科学学院保定 071002;
b 河北大学医学部河北省化学生物学重点实验室保定 071002

收稿日期:2011-11-29 修回日期:2011-12-12 发布日期:2012-01-06
通讯作者: 李小六 E-mail:lixl@hbu.cn
基金资助:
国家自然科学基金(Nos. 20972039, 21172051)、河北省自然科学基金(No. B2011201169)、河北省教育厅自然科学基金(Nos. 2009309, ZH2011110,Y2011119)、河北省科学技术研究与发展计划(No. 09276418D-13)资助项目.

Synthesis and Proliferative Effects on T Lymphocytes of Novel Thiazolidin-4-one Linked Pseudotrisaccharides

Chen Hua^a, Gao Fang^a, Yin Qingmei^a, Li Chunxiao^b, Li Na^b, Meng Ming^b, Li Xiaoliu^a

a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science,Hebei University, Baoding 071002;
b Medical School, Hebei University, Baoding 071002

Received:2011-11-29 Revised:2011-12-12 Published:2012-01-06
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 20972039, 21172051), the Natural Science Foundation of Hebei Province (No. B2011201169), the Natural Science Foundations of Education Department of Hebei Province (Nos. 2009309, ZH2011110, Y2011119), and the Program of Science and Technology of Hebei Province (No. 09276418D-13).

Novel thiazolidin-4-one-linked pseudotrisaccharides 3a and 3b were synthesized by the one-pot tandem Staudinger/ aza-Wittig/cyclization reaction at room temperature starting from a bis-azidosugar, a sugar aldehyde and mercaptoacetic acid. The debenzoylation of 3a and 3b afforded the corresponding compounds 4a and 4b, respectively. The preliminary biological evaluation of compounds 4a and 4b showed that compounds 4a and 4b had significant effects on T-cell proliferation, and hold potential as immunostimulating agents.

Key words: thiazolidin-4-one, pseudotrisaccharides, immunostimulating agent

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Chen Hua, Gao Fang, Yin Qingmei, Li Chunxiao, Li Na, Meng Ming, Li Xiaoliu. Synthesis and Proliferative Effects on T Lymphocytes of Novel Thiazolidin-4-one Linked Pseudotrisaccharides[J]. Chin. J. Org. Chem., 2012, 32(05): 943-948.

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噻唑烷-4-酮连假三糖的合成及其对T 淋巴细胞增殖活性研究

Synthesis and Proliferative Effects on T Lymphocytes of Novel Thiazolidin-4-one Linked Pseudotrisaccharides

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