Sequential One-Pot Synthesis of 5,6,8-Trihydropyrano[3',4':4,5]thieno[2,3-d]pyrimidin-4(3H)-one

doi:DOI: 10.6023/cjoc1111172

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (07): 1314-1318.DOI: DOI: 10.6023/cjoc1111172 Previous Articles Next Articles

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顺序一锅法合成5,6,8-三氢-吡喃并[3',4':4,5]噻吩并[2,3-d]嘧啶-4(3H)-酮衍生物

陈莉^a,b, 孙绍发^a,b, 宋功武^b

a 咸宁学院药学院湖北咸宁 437100;
b 湖北大学化学化工学院湖北武汉 430062

收稿日期:2011-11-17 修回日期:2012-01-07 发布日期:2012-03-05
通讯作者: 孙绍发 E-mail:ssf8223@yahoo.com.cn
基金资助:
湖北省自然科学基金(No. 2010CDZ048)资助项目.

Sequential One-Pot Synthesis of 5,6,8-Trihydropyrano[3',4':4,5]thieno[2,3-d]pyrimidin-4(3H)-one

Chen Li^a,b, Sun Shaofa^a,b, Song Gongwu^b

a School of Pharmacy, Xianning College, Xianning, Hubei 437100;
b College of Chemistry and Chemical engineering, Hubei Universit, Wuhan, Hubei 430062

Received:2011-11-17 Revised:2012-01-07 Published:2012-03-05
Supported by:
Project supported by the Natural Science Foundation of Hubei Province (No. 2010CDZ048).

Nineteen novel 5,6,8-trihydropyrano [3',4':4,5] thieno [2,3-d] pyrimidin-4(3H)-one derivatives were synthsized using the sequential one-pot reaction, from 4,5,7-trihydropyrano [4,3-d] thiophen-2-ylimino-triphenyl-phosohorane, aryl-isocyanate and primary amine or secondary amine. Their structures were characterized by ¹H NMR, IR and MS. Meanwhile, the structure of 3-(4-chlorophenyl)-2-(diethylamino)-5,6,8-trihydropyrano [3',4':4,5] thieno [2,3-d] pyrimidin-4(3H)-one (4a) was further confirmed by X-ray single diffraction method.

Key words: sequential one-pot reaction, aza-Wittig reaction, thienopyrimidinone, crystal structure

Cite this article

Chen Li, Sun Shaofa, Song Gongwu. Sequential One-Pot Synthesis of 5,6,8-Trihydropyrano[3',4':4,5]thieno[2,3-d]pyrimidin-4(3H)-one[J]. Chin. J. Org. Chem., 2012, 32(07): 1314-1318.

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顺序一锅法合成5,6,8-三氢-吡喃并[3',4':4,5]噻吩并[2,3-d]嘧啶-4(3H)-酮衍生物

Sequential One-Pot Synthesis of 5,6,8-Trihydropyrano[3',4':4,5]thieno[2,3-d]pyrimidin-4(3H)-one

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