Progress in the Application of Organocatalysis to Asymmetric Michael Additions

doi:10.6023/cjoc201203009

Abstract

Organocatalysis has become one of the most intensively research fields. Asymmetric Michael addition is a key method for synthesis of versatile synthetic buildings and pharmaceutical intermediates, which include one or more stereo-chemical centers. The organocatalysts reported over the past three years for the asymmetric Michael addition are reviewed including primary amine, pyrrolidine based derivatives, (thio) urea, chiral squaramides and phosphoric acids. The relationship between structure of organocatalysts and their catalytic activities, catalytic reaction mechanism and the applications of these protocols for the preparation of drugs and bioactive intermediates are also introduced.

Key words: asymmetric Michael addition, organocatalysis, enantioselectivity, application

Cite this article

Ying Anguo, Wu Chenglin, Fu Yongqian, Ren Shibin, Liang Huading. Progress in the Application of Organocatalysis to Asymmetric Michael Additions[J]. Chin. J. Org. Chem., 2012, 32(9): 1587-1604.

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