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Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (11): 2166-2170.DOI: 10.6023/cjoc201206009 Previous Articles     Next Articles

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聚乙二醇-聚乳酸-聚甲基丙烯酸羟乙酯两亲性三嵌段聚合物的合成及其自组装研究

席陈彬a, 杨东a, 李静b, 晏建军b, 胡建华a   

  1. a 复旦大学高分子科学系 聚合物分子工程国家重点实验室 上海 200433;
    b 第二军医大学东方肝胆外科医院肝外一科 上海 200438
  • 收稿日期:2012-06-09 修回日期:2012-07-09 发布日期:2012-07-17
  • 通讯作者: 晏建军, 胡建华 E-mail:rian1971@126.com; hujh@fudan.edu.cn
  • 基金资助:

    国家自然科学基金(Nos. 50873029, 51073042, 51103026)、上海科技创新行动计划(No. 11JC1400600)、上海市自然科学基金(No. 11ZR1403100)和高等学校博士学科点专项科研基金(No. 20110071120006)资助项目.

Synthesis and Self-assembly of Poly(ethylene oxide)-b- poly(lactic acid)-b-poly(2-hydroxyethyl methacrylate) Amphiphilic Triblock Copolymer

Xi Chenbina, Yang Donga, Li Jingb, Yan Jianjunb, Hu Jianhuaa   

  1. a State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433;
    b Department of Hepatic Surgery I, Secondary Military Medical University, Shanghai 200438
  • Received:2012-06-09 Revised:2012-07-09 Published:2012-07-17
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 50873029, 51073042, 51103026), the Shanghai Scientific and Technological Innovation Project (No. 11JC1400600), the Natural Science Foundation of Shanghai City (No. 11ZR1403100), and the Specialized Research Fund for the Doctoral Program of Higher Education (No. 20110071120006).

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Amphiphilic copolymers that can assemble into core-shell micelles in aqueous media have potential application as drug carriers for controlled-release. In this article an amphiphilic triblock copolymer poly(ethylene oxide)-block-poly(lactic acid)-block-poly(2-hydroxyethyl methacrylate) (PEG-b-PLA-b-PHEMA) was synthesized by ring-opening reaction and atom transfer radical polymerization. The polymers were characterized by 1H NMR, FT-IR and gel permeation chromatography. In aqueous solution, PEG-b-PLA-b-PHEMA can self-assemble into micelles. Characterized by DLS and TEM, micelles are found to be spherical with uniform size. Large numbers of hydroxyl groups on the PHEMA chain offer reaction sites for subsequent functional modification, which make it a promising platforms for drug delivery systems.

Key words: amphiphilic, ATRP, PLA, PHEMA, micelle