Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (8): 2764-2789.DOI: 10.6023/cjoc202211029 Previous Articles Next Articles
吴秀蓉a,b, 肖朝江a, 沈怡a, 汤红霞b, 朱俊逸b, 姜北a,*(
)
收稿日期:2022-11-24
修回日期:2023-03-19
发布日期:2023-04-07
基金资助:
Xiurong Wua,b, Chaojiang Xiaoa, Yi Shena, Hongxia Tangb, Junyi Zhub, Bei Jianga()
Received:2022-11-24
Revised:2023-03-19
Published:2023-04-07
Contact:
*E-mail: Supported by:Share
Xiurong Wu, Chaojiang Xiao, Yi Shen, Hongxia Tang, Junyi Zhu, Bei Jiang. Research Progress on Antimalarial Natural Sesquiterpenoids from Plants from 1972 to 2022[J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2764-2789.
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Anthecotulide (1) | Asteraceae | Anthemis auriculata | 16.11 (K1) | 2008[ |
| 4-Hydroxyanthecotulide (2) | Asteraceae | Anthemis auriculata | 7.57 (K1) | 2008[ |
| 4-Acetoxyanthecotulide (3) | Asteraceae | Anthemis auriculata | 16.65 (K1) | 2008[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Anthecotulide (1) | Asteraceae | Anthemis auriculata | 16.11 (K1) | 2008[ |
| 4-Hydroxyanthecotulide (2) | Asteraceae | Anthemis auriculata | 7.57 (K1) | 2008[ |
| 4-Acetoxyanthecotulide (3) | Asteraceae | Anthemis auriculata | 16.65 (K1) | 2008[ |
| Compd. | Family | Plant | IC50 or EC50/(μmol•L－1) | Year | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trichospirolide A (4) | Asteraceae | Trichospira verticillata | 1.5 (Dd2) | 2017[ | ||||||||
| Trichospirolide B (5) | Asteraceae | Trichospira verticillata | 37.0 (Dd2) | 2017[ | ||||||||
| 9α-Acetoxy-15-hydroxy-8β-(2-methyl- butyryloxy)-14-oxo-4,5-trans-acantho- spermolide (6) | Asteraceae | Acanthospermum hispidum | 2.23±0.09 (3D7) | 2012[ | ||||||||
| Urospermal A-15-O-acetate (7) | Asteraceae | Dicoma tomentosa | 2.87±0.16 (3D7) | 2012[ | ||||||||
| 2.41±0.78 (W2) | ||||||||||||
| Neurolenin A (8) | Asteraceae | Neurolaena lobata | 0.92 (NF54) | 1996[ | ||||||||
| Neurolenin B (9) | Asteraceae | Neurolaena lobata | 0.62 (NF54) | 1996[ | ||||||||
| Lobatin A (10) | Asteraceae | Neurolaena lobata | 15.62 (NF54) | 1996[ | ||||||||
| Trichospirolide C (11) | Asteraceae | Trichospira verticillata | 12.1 (Dd2) | 2017[ | ||||||||
| 16,17-Dihydrobrachycalyxolide (12) | Asteraceae | Vernonia brachycalyx | 8.3 (K39) | 1998[ | ||||||||
| 27 (3D7) | ||||||||||||
| 5.9 (V1/S) | ||||||||||||
| 32 (Dd2) | ||||||||||||
| 15-Acetoxy-8β-[(2-methylbutyryloxy)]- 14-oxo-4,5-cis-acanthospermolide (13) | Asteraceae | Acanthospermum hispidum | 2.9±0.5 (3D7) | 2012[ | ||||||||
| Ineupatorolide A (14) | Asteraceae | Carpesium rosulatum | 0.02 (D10) | 2007[ | ||||||||
| Asteraceae | Carpesium rosulatum | 86.5%, 10 mg•kg－1•d－1 (P. berghei) | 2008[ | |||||||||
| Schkuhrin I (15) | Asteraceae | Schkuhria pinnata | 2.05 (NF54) | 2013[ | ||||||||
| Schkuhrin II (16) | Asteraceae | Schkuhria pinnata | 1.67 (NF54) | 2013[ | ||||||||
| Lobatin B (17) | Asteraceae | Neurolaena lobata | 16.51 (NF54) | 1996[ | ||||||||
| Trichospirolide D (18) | Asteraceae | Trichospira verticillata | 44.3 (Dd2) | 2017[ | ||||||||
| 8α-(2-Methylacryloyloxy)-3-oxo-1-de- soxy-1,2-dehydrohirsutinolide-13-O- acetate (19) | Asteraceae | Vernonia staehelinoides | 0.67 (D10) | 2007[ | ||||||||
| 4.47 (K1) | ||||||||||||
| 8α-(5'-Acetoxysenecioyloxy)-3-oxo-1- desoxy-1,2-dehydrohirsutinolide-13-O- acetate (20) | Asteraceae | Vernonia staehelinoides | 0.51 (D10) | 2007[ | ||||||||
| 5.48 (K1) | ||||||||||||
| Vernolide D (21) | Asteraceae | Vernonia cinerea | 3.5 (W2) | 2006[ | ||||||||
| 8α-(4-Hydroxymethacryloyloxy)- hirsutinolide-13-O-acetate (22) | Asteraceae | Vernonia cinerea | 3.7 (W2) | 2006[ | ||||||||
| 8α-Tigloyloxy-hirsutinolide-13-O- acetate (23) | Asteraceae | Vernonia cinerea | 3.9 (W2) | 2006[ | ||||||||
| 5-O-Methyl-5-epiisogoyazensolide (24) | Asteraceae | Piptocoma antillana | 6.2±0.5 (Dd2) | 2014[ | ||||||||
| 15-O-Methylgoyazensolide (25) | Asteraceae | Piptocoma antillana | 2.2±0.5 (Dd2) | 2014[ | ||||||||
| 1-Oxo-3,10-epoxy-8-(2-methylacryloxy)- 15-acetoxygermacra-2,4,11(13)-trien- 6(12)-olide (26) | Asteraceae | Piptocoma antillana | 8.0±0.4 (Dd2) | 2014[ | ||||||||
| 5-epi-Isogoyazensolide (27) | Asteraceae | Piptocoma antillana | 9.0±0.6 (Dd2) | 2014[ | ||||||||
| Asteraceae | Camchaya calcarea | 4.44 (K1) | 2006[ | |||||||||
| Goyazensolide (28) | Asteraceae | Camchaya calcarea | 3.33 (K1) | 2006[ | ||||||||
| Lychnophorolide A (29) | Asteraceae | Camchaya calcarea | 0.80 (K1) | 2006[ | ||||||||
| Lychnophorolide B (30) | Asteraceae | Camchaya calcarea | 7.21 (K1) | 2006[ | ||||||||
| Isogoyazensolide (31) | Asteraceae | Camchaya calcarea | 4.44 (K1) | 2006[ | ||||||||
| Isocentratherin (32) | Asteraceae | Camchaya calcarea | 5.61 (K1) | 2006[ | ||||||||
| 5-epi-Isocentratherin (33) | Asteraceae | Camchaya calcarea | 8.01 (K1) | 2006[ | ||||||||
| 9α-Hydroxy-8β-isovalerianyloxycaly- culatolide (34) | Asteraceae | Neurolaena lobata | 19.27 (NF54) | 1996[ | ||||||||
| Vernolide (35) | Asteraceae | Vernonia colorata | 5.16 (D10) | 2009[ | ||||||||
| Asteraceae | Vernonia amygdalina | 23.18 (K1) | 2009[ | |||||||||
| Hydroxyvernolide (36) | Asteraceae | Vernonia amygdalina | 30.13 (K1) | 2009[ | ||||||||
| Parthenolide (37) | Magnoliaceae | Magnolia champaca | (85.18±0.50)%, 20 mg•kg－1•d－1 (P. berghei) | 2017[ | ||||||||
| Costunolide diepoxide (38) | Magnoliaceae | Magnolia champaca | (83.65±0.33)%, 20 mg•kg－1•d－1 (P. berghei) | 2017[ | ||||||||
| Peroxyferolide (39) | Magnoliaceae | Liriodendron tulipifera | 18.3±0.3 (D10) | 2011[ | ||||||||
| 12.7±3.5 (Dd2) | ||||||||||||
| Lipiferolide (40) | Magnoliaceae | Liriodendron tulipifera | 5.9±2.3 (D10) | 2011[ | ||||||||
| 7.5±0.3 (Dd2) | ||||||||||||
| Ridentin (41) | Asteraceae | Artemisia gorgonum | 20.43±4.54 (FcB1) | 2008[ | ||||||||
| Hanphyllin (42) | Asteraceae | Artemisia gorgonum | 9.26±3.62 (FcB1) | 2008[ | ||||||||
| Tagitinin C (43) | Asteraceae | Tithonia diversifolia | 0.95 (FCA) | 2003[ 2002[ | ||||||||
| 0.72 (FCB1) | ||||||||||||
| Asteraceae | Tithonia diversifolia | 1.55 (NF54) | 2021[ | |||||||||
| Orizabin (44) | Asteraceae | Tithonia diversifolia | 2.28 (NF54) | 2021[ | ||||||||
| Vernopicrin (45) | Asteraceae | Vernonia guineensis | 2.33±0.57 (Dd2) | 2013[ | ||||||||
| 1.77±0.32 (Hb3) | ||||||||||||
| Vernangulide A (46) | Asteraceae | Distephanus angulifolius | 1.90±0.10 (D10) | 2009[ | ||||||||
| 3.24±0.27 (W2) | ||||||||||||
| 1β-Hydroperoxyisonobilin (47) | Asteraceae | Anthemis nobilis | 2.64 (FCH5) | 1991[ | ||||||||
| 11(13)-Dehydroivaxillin (48) | Asteraceae | Carpesium cernum | 87.7%, 10 mg•kg－1•d－1 (P. berghei) | 2009[ | ||||||||
| Asteraceae | Carpesium cernum | 2.01 (D10) | 2009[ | |||||||||
| Ivaxillin (49) | Asteraceae | Carpesium cernum | 16.31 (D10) | 2009[ | ||||||||
| 11-epi-Ivaxillin (50) | Asteraceae | Carpesium cernum | 8.91 (D10) | 2009[ | ||||||||
| 4,5α-Epoxy-6α-acetoxy-1(10)E,11(13)- germacradien-12,8α-olide (51) | Asteraceae | Oncosiphon piluliferum | 1.63 (D10) | 2007[ | ||||||||
| Tatridin A (52) | Asteraceae | Oncosiphon piluliferum | 1.51 (D10) | 2007[ | ||||||||
| Tanachin (53) | Asteraceae | Oncosiphon piluliferum | 1.89 (D10) | 2007[ | ||||||||
| Furanodienone (54) | Burseraceae | Commiphora myrrh | 7.4 (NF54) | 2020[ | ||||||||
| (1(10)E)-2-Methoxy-8,12-epoxygermacra- 1(10),7,11-trien-6-one (55) | Burseraceae | Commiphora myrrh | 24 (NF54) | 2020[ | ||||||||
| 2R-Methoxyfuranodiene (56) | Burseraceae | Commiphora myrrh | 12 (NF54) | 2020[ | ||||||||
| 1(10)Z,4Z-Furanodien-6-one (57) | Burseraceae | Commiphora myrrh | 18 (NF54) | 2020[ | ||||||||
| Rel-2R-methyl-5S-acetoxy-4R-furanogerma- cr-1(10)Z-en-6-one (58) | Burseraceae | Commiphora myrrh | 12 (NF54) | 2020[ | ||||||||
| (1R,2R,4S)-1,2-Epoxyfuranogermacr-10(15)- en-6-one (59) | Burseraceae | Commiphora myrrh | 24 (NF54) | 2020[ | ||||||||
| 5E,10(14)-Germacradien-1β,4β-diol (60) | Zingiberaceae | Reneilmia cincinnata | 6.84 (D6) | 1999[ | ||||||||
| 133.83 (W2) | ||||||||||||
| 1(10)E,5E-Germacradien-4α-ol (61) | Zingiberaceae | Reneilmia cincinnata | 6.93 (D6) | 1999[ | ||||||||
| 8.54 (W2) | ||||||||||||
| 6-O-Angeloyl-8-O-senecioyl-6β,8α,11- trihydroxygermacra-1(10)E,4E-diene (62) | Apiaceae | Daucus carota | 96.4 (P. berghei) | 2021[ | ||||||||
| 6-O-Tigloyl-8-O-isovaleryl-6β,8α,11- trihydroxygermacra-1(10)E,4E-diene (63) | Apiaceae | Daucus carota | 1189 (P. berghei) | 2021[ | ||||||||
| 6-O-Tigloyl-8-O-2-methylbutyryl-lα,6β,8α,11- tetrahydroxygermacra-4E,10(14)-diene (64) | Apiaceae | Daucus carota | 115.8 (P. berghei) | 2021[ | ||||||||
| Daucovirgolide G (65) | Apiaceae | Daucus carota | 17.5 (P. berghei) | 2021[ | ||||||||
| Compd. | Family | Plant | IC50 or EC50/(μmol•L－1) | Year | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trichospirolide A (4) | Asteraceae | Trichospira verticillata | 1.5 (Dd2) | 2017[ | ||||||||
| Trichospirolide B (5) | Asteraceae | Trichospira verticillata | 37.0 (Dd2) | 2017[ | ||||||||
| 9α-Acetoxy-15-hydroxy-8β-(2-methyl- butyryloxy)-14-oxo-4,5-trans-acantho- spermolide (6) | Asteraceae | Acanthospermum hispidum | 2.23±0.09 (3D7) | 2012[ | ||||||||
| Urospermal A-15-O-acetate (7) | Asteraceae | Dicoma tomentosa | 2.87±0.16 (3D7) | 2012[ | ||||||||
| 2.41±0.78 (W2) | ||||||||||||
| Neurolenin A (8) | Asteraceae | Neurolaena lobata | 0.92 (NF54) | 1996[ | ||||||||
| Neurolenin B (9) | Asteraceae | Neurolaena lobata | 0.62 (NF54) | 1996[ | ||||||||
| Lobatin A (10) | Asteraceae | Neurolaena lobata | 15.62 (NF54) | 1996[ | ||||||||
| Trichospirolide C (11) | Asteraceae | Trichospira verticillata | 12.1 (Dd2) | 2017[ | ||||||||
| 16,17-Dihydrobrachycalyxolide (12) | Asteraceae | Vernonia brachycalyx | 8.3 (K39) | 1998[ | ||||||||
| 27 (3D7) | ||||||||||||
| 5.9 (V1/S) | ||||||||||||
| 32 (Dd2) | ||||||||||||
| 15-Acetoxy-8β-[(2-methylbutyryloxy)]- 14-oxo-4,5-cis-acanthospermolide (13) | Asteraceae | Acanthospermum hispidum | 2.9±0.5 (3D7) | 2012[ | ||||||||
| Ineupatorolide A (14) | Asteraceae | Carpesium rosulatum | 0.02 (D10) | 2007[ | ||||||||
| Asteraceae | Carpesium rosulatum | 86.5%, 10 mg•kg－1•d－1 (P. berghei) | 2008[ | |||||||||
| Schkuhrin I (15) | Asteraceae | Schkuhria pinnata | 2.05 (NF54) | 2013[ | ||||||||
| Schkuhrin II (16) | Asteraceae | Schkuhria pinnata | 1.67 (NF54) | 2013[ | ||||||||
| Lobatin B (17) | Asteraceae | Neurolaena lobata | 16.51 (NF54) | 1996[ | ||||||||
| Trichospirolide D (18) | Asteraceae | Trichospira verticillata | 44.3 (Dd2) | 2017[ | ||||||||
| 8α-(2-Methylacryloyloxy)-3-oxo-1-de- soxy-1,2-dehydrohirsutinolide-13-O- acetate (19) | Asteraceae | Vernonia staehelinoides | 0.67 (D10) | 2007[ | ||||||||
| 4.47 (K1) | ||||||||||||
| 8α-(5'-Acetoxysenecioyloxy)-3-oxo-1- desoxy-1,2-dehydrohirsutinolide-13-O- acetate (20) | Asteraceae | Vernonia staehelinoides | 0.51 (D10) | 2007[ | ||||||||
| 5.48 (K1) | ||||||||||||
| Vernolide D (21) | Asteraceae | Vernonia cinerea | 3.5 (W2) | 2006[ | ||||||||
| 8α-(4-Hydroxymethacryloyloxy)- hirsutinolide-13-O-acetate (22) | Asteraceae | Vernonia cinerea | 3.7 (W2) | 2006[ | ||||||||
| 8α-Tigloyloxy-hirsutinolide-13-O- acetate (23) | Asteraceae | Vernonia cinerea | 3.9 (W2) | 2006[ | ||||||||
| 5-O-Methyl-5-epiisogoyazensolide (24) | Asteraceae | Piptocoma antillana | 6.2±0.5 (Dd2) | 2014[ | ||||||||
| 15-O-Methylgoyazensolide (25) | Asteraceae | Piptocoma antillana | 2.2±0.5 (Dd2) | 2014[ | ||||||||
| 1-Oxo-3,10-epoxy-8-(2-methylacryloxy)- 15-acetoxygermacra-2,4,11(13)-trien- 6(12)-olide (26) | Asteraceae | Piptocoma antillana | 8.0±0.4 (Dd2) | 2014[ | ||||||||
| 5-epi-Isogoyazensolide (27) | Asteraceae | Piptocoma antillana | 9.0±0.6 (Dd2) | 2014[ | ||||||||
| Asteraceae | Camchaya calcarea | 4.44 (K1) | 2006[ | |||||||||
| Goyazensolide (28) | Asteraceae | Camchaya calcarea | 3.33 (K1) | 2006[ | ||||||||
| Lychnophorolide A (29) | Asteraceae | Camchaya calcarea | 0.80 (K1) | 2006[ | ||||||||
| Lychnophorolide B (30) | Asteraceae | Camchaya calcarea | 7.21 (K1) | 2006[ | ||||||||
| Isogoyazensolide (31) | Asteraceae | Camchaya calcarea | 4.44 (K1) | 2006[ | ||||||||
| Isocentratherin (32) | Asteraceae | Camchaya calcarea | 5.61 (K1) | 2006[ | ||||||||
| 5-epi-Isocentratherin (33) | Asteraceae | Camchaya calcarea | 8.01 (K1) | 2006[ | ||||||||
| 9α-Hydroxy-8β-isovalerianyloxycaly- culatolide (34) | Asteraceae | Neurolaena lobata | 19.27 (NF54) | 1996[ | ||||||||
| Vernolide (35) | Asteraceae | Vernonia colorata | 5.16 (D10) | 2009[ | ||||||||
| Asteraceae | Vernonia amygdalina | 23.18 (K1) | 2009[ | |||||||||
| Hydroxyvernolide (36) | Asteraceae | Vernonia amygdalina | 30.13 (K1) | 2009[ | ||||||||
| Parthenolide (37) | Magnoliaceae | Magnolia champaca | (85.18±0.50)%, 20 mg•kg－1•d－1 (P. berghei) | 2017[ | ||||||||
| Costunolide diepoxide (38) | Magnoliaceae | Magnolia champaca | (83.65±0.33)%, 20 mg•kg－1•d－1 (P. berghei) | 2017[ | ||||||||
| Peroxyferolide (39) | Magnoliaceae | Liriodendron tulipifera | 18.3±0.3 (D10) | 2011[ | ||||||||
| 12.7±3.5 (Dd2) | ||||||||||||
| Lipiferolide (40) | Magnoliaceae | Liriodendron tulipifera | 5.9±2.3 (D10) | 2011[ | ||||||||
| 7.5±0.3 (Dd2) | ||||||||||||
| Ridentin (41) | Asteraceae | Artemisia gorgonum | 20.43±4.54 (FcB1) | 2008[ | ||||||||
| Hanphyllin (42) | Asteraceae | Artemisia gorgonum | 9.26±3.62 (FcB1) | 2008[ | ||||||||
| Tagitinin C (43) | Asteraceae | Tithonia diversifolia | 0.95 (FCA) | 2003[ 2002[ | ||||||||
| 0.72 (FCB1) | ||||||||||||
| Asteraceae | Tithonia diversifolia | 1.55 (NF54) | 2021[ | |||||||||
| Orizabin (44) | Asteraceae | Tithonia diversifolia | 2.28 (NF54) | 2021[ | ||||||||
| Vernopicrin (45) | Asteraceae | Vernonia guineensis | 2.33±0.57 (Dd2) | 2013[ | ||||||||
| 1.77±0.32 (Hb3) | ||||||||||||
| Vernangulide A (46) | Asteraceae | Distephanus angulifolius | 1.90±0.10 (D10) | 2009[ | ||||||||
| 3.24±0.27 (W2) | ||||||||||||
| 1β-Hydroperoxyisonobilin (47) | Asteraceae | Anthemis nobilis | 2.64 (FCH5) | 1991[ | ||||||||
| 11(13)-Dehydroivaxillin (48) | Asteraceae | Carpesium cernum | 87.7%, 10 mg•kg－1•d－1 (P. berghei) | 2009[ | ||||||||
| Asteraceae | Carpesium cernum | 2.01 (D10) | 2009[ | |||||||||
| Ivaxillin (49) | Asteraceae | Carpesium cernum | 16.31 (D10) | 2009[ | ||||||||
| 11-epi-Ivaxillin (50) | Asteraceae | Carpesium cernum | 8.91 (D10) | 2009[ | ||||||||
| 4,5α-Epoxy-6α-acetoxy-1(10)E,11(13)- germacradien-12,8α-olide (51) | Asteraceae | Oncosiphon piluliferum | 1.63 (D10) | 2007[ | ||||||||
| Tatridin A (52) | Asteraceae | Oncosiphon piluliferum | 1.51 (D10) | 2007[ | ||||||||
| Tanachin (53) | Asteraceae | Oncosiphon piluliferum | 1.89 (D10) | 2007[ | ||||||||
| Furanodienone (54) | Burseraceae | Commiphora myrrh | 7.4 (NF54) | 2020[ | ||||||||
| (1(10)E)-2-Methoxy-8,12-epoxygermacra- 1(10),7,11-trien-6-one (55) | Burseraceae | Commiphora myrrh | 24 (NF54) | 2020[ | ||||||||
| 2R-Methoxyfuranodiene (56) | Burseraceae | Commiphora myrrh | 12 (NF54) | 2020[ | ||||||||
| 1(10)Z,4Z-Furanodien-6-one (57) | Burseraceae | Commiphora myrrh | 18 (NF54) | 2020[ | ||||||||
| Rel-2R-methyl-5S-acetoxy-4R-furanogerma- cr-1(10)Z-en-6-one (58) | Burseraceae | Commiphora myrrh | 12 (NF54) | 2020[ | ||||||||
| (1R,2R,4S)-1,2-Epoxyfuranogermacr-10(15)- en-6-one (59) | Burseraceae | Commiphora myrrh | 24 (NF54) | 2020[ | ||||||||
| 5E,10(14)-Germacradien-1β,4β-diol (60) | Zingiberaceae | Reneilmia cincinnata | 6.84 (D6) | 1999[ | ||||||||
| 133.83 (W2) | ||||||||||||
| 1(10)E,5E-Germacradien-4α-ol (61) | Zingiberaceae | Reneilmia cincinnata | 6.93 (D6) | 1999[ | ||||||||
| 8.54 (W2) | ||||||||||||
| 6-O-Angeloyl-8-O-senecioyl-6β,8α,11- trihydroxygermacra-1(10)E,4E-diene (62) | Apiaceae | Daucus carota | 96.4 (P. berghei) | 2021[ | ||||||||
| 6-O-Tigloyl-8-O-isovaleryl-6β,8α,11- trihydroxygermacra-1(10)E,4E-diene (63) | Apiaceae | Daucus carota | 1189 (P. berghei) | 2021[ | ||||||||
| 6-O-Tigloyl-8-O-2-methylbutyryl-lα,6β,8α,11- tetrahydroxygermacra-4E,10(14)-diene (64) | Apiaceae | Daucus carota | 115.8 (P. berghei) | 2021[ | ||||||||
| Daucovirgolide G (65) | Apiaceae | Daucus carota | 17.5 (P. berghei) | 2021[ | ||||||||
| Compd. | Family | Plant | IC50 or EC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Zingiberene-3,6-α-endoperoxide (66) | Asteraceae | Senecio selloi/Eupatorium rufescens | 42.31 (FCH5) | 1996[ |
| Zingiberene-3,6-β-endoperoxide (67) | Asteraceae | Senecio selloi/Eupatorium rufescens | 42.31 (FCH5) | 1996[ |
| Yingzhaosu A (68) | Annonaceae | Artabotrys uncinatus | 0.12 (K1) | 2005[ |
| 69 | Asteraceae | Artemisia persica | 2.8±0.4 (K1) | 2013[ |
| 70 | Asteraceae | Artemisia persica | 14.9±1.7 (K1) | 2013[ |
| 71 | Asteraceae | Artemisia persica | 20.1±0.7 (K1) | 2013[ |
| 72 | Asteraceae | Artemisia persica | 19.1±2.2 (K1) | 2013[ |
| 1(S*)-Hydroxy-α-bisabololoxide A acetate (73) | Asteraceae | Artemisia abrotanum | 17.17 (K1) | 1990[ |
| Compd. | Family | Plant | IC50 or EC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Zingiberene-3,6-α-endoperoxide (66) | Asteraceae | Senecio selloi/Eupatorium rufescens | 42.31 (FCH5) | 1996[ |
| Zingiberene-3,6-β-endoperoxide (67) | Asteraceae | Senecio selloi/Eupatorium rufescens | 42.31 (FCH5) | 1996[ |
| Yingzhaosu A (68) | Annonaceae | Artabotrys uncinatus | 0.12 (K1) | 2005[ |
| 69 | Asteraceae | Artemisia persica | 2.8±0.4 (K1) | 2013[ |
| 70 | Asteraceae | Artemisia persica | 14.9±1.7 (K1) | 2013[ |
| 71 | Asteraceae | Artemisia persica | 20.1±0.7 (K1) | 2013[ |
| 72 | Asteraceae | Artemisia persica | 19.1±2.2 (K1) | 2013[ |
| 1(S*)-Hydroxy-α-bisabololoxide A acetate (73) | Asteraceae | Artemisia abrotanum | 17.17 (K1) | 1990[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| (8R*)-8-Bromo-10-epi-β-snyderol (74) | Rhodomelaceae | Laurencia obtusa | 10.52 (W2) | 2003[ |
| 7.10 (D6) | ||||
| 75 | Rhodomelaceae | Laurencia implicata | 4.45 (W2) | 1994[ |
| 16.31 (D6) | ||||
| Aplysistatin (76) | Rhodomelaceae | Laurencia implicata | 2.70 (W2) | 1994[ |
| 2.25 (D6) | ||||
| 5β-Hydroxyaplysistatin (77) | Rhodomelaceae | Laurencia implicata | 1.27 (W2) | 1994[ |
| 1.07 (D6) |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| (8R*)-8-Bromo-10-epi-β-snyderol (74) | Rhodomelaceae | Laurencia obtusa | 10.52 (W2) | 2003[ |
| 7.10 (D6) | ||||
| 75 | Rhodomelaceae | Laurencia implicata | 4.45 (W2) | 1994[ |
| 16.31 (D6) | ||||
| Aplysistatin (76) | Rhodomelaceae | Laurencia implicata | 2.70 (W2) | 1994[ |
| 2.25 (D6) | ||||
| 5β-Hydroxyaplysistatin (77) | Rhodomelaceae | Laurencia implicata | 1.27 (W2) | 1994[ |
| 1.07 (D6) |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Zerumbone (78) | Zingiberaceae | Zingiber zerumbet | 11.8 (K1) | 2013[ |
| Kurubasch aldehyde (79) | Meliaceae | Trichilia emetica | 76±10 (3D7) | 2007[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Zerumbone (78) | Zingiberaceae | Zingiber zerumbet | 11.8 (K1) | 2013[ |
| Kurubasch aldehyde (79) | Meliaceae | Trichilia emetica | 76±10 (3D7) | 2007[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Vernodalol (80) | Asteraceae | Distephanus angulifolius | 3.82±0.08 (D10) | 2009[ |
| 4.94±0.18 (W2) | ||||
| Asteraceae | Vernonia amygdalin | 10.70 (K1) | 2009[ | |
| Asteraceae | Vernonia colorata | 10.19 (PoW) | 2003[ | |
| 12.23 (Dd2) | ||||
| Vernodalin (81) | Asteraceae | Distephanus angulifolius | 1.75±0.35 (D10) | 2009[ |
| 2.69±0.26 (W2) | ||||
| Asteraceae | Vernonia amygdalin | 11.10 (K1) | 2009[ | |
| 11β,13-Dihydrovernodalin (82) | Asteraceae | Vernonia colorata | 6.35 (PoW) | 2003[ |
| 3.04 (Dd2) | ||||
| Vernangulide B (83) | Asteraceae | Distephanus angulifolius | 1.55±0.02 (D10) | 2009[ |
| 2.10±0.17 (W2) | ||||
| Vernomelitensin (84) | Asteraceae | Vernonia guineensis | 1.64±0.22 (Dd2) | 2013[ |
| 1.36±0.25 (Hb3) | ||||
| 85 | Apiaceae | Daucus carota | 249.9 (P. berghei) | 2021[ |
| 8-Hydroxyisogermafurenolide (86) | Burseraceae | Commiphora myrrh | 30 (NF54) | 2020[ |
| Elemyl acetate (87) | Burseraceae | Commiphora myrrh | 12 (NF54) | 2020[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Vernodalol (80) | Asteraceae | Distephanus angulifolius | 3.82±0.08 (D10) | 2009[ |
| 4.94±0.18 (W2) | ||||
| Asteraceae | Vernonia amygdalin | 10.70 (K1) | 2009[ | |
| Asteraceae | Vernonia colorata | 10.19 (PoW) | 2003[ | |
| 12.23 (Dd2) | ||||
| Vernodalin (81) | Asteraceae | Distephanus angulifolius | 1.75±0.35 (D10) | 2009[ |
| 2.69±0.26 (W2) | ||||
| Asteraceae | Vernonia amygdalin | 11.10 (K1) | 2009[ | |
| 11β,13-Dihydrovernodalin (82) | Asteraceae | Vernonia colorata | 6.35 (PoW) | 2003[ |
| 3.04 (Dd2) | ||||
| Vernangulide B (83) | Asteraceae | Distephanus angulifolius | 1.55±0.02 (D10) | 2009[ |
| 2.10±0.17 (W2) | ||||
| Vernomelitensin (84) | Asteraceae | Vernonia guineensis | 1.64±0.22 (Dd2) | 2013[ |
| 1.36±0.25 (Hb3) | ||||
| 85 | Apiaceae | Daucus carota | 249.9 (P. berghei) | 2021[ |
| 8-Hydroxyisogermafurenolide (86) | Burseraceae | Commiphora myrrh | 30 (NF54) | 2020[ |
| Elemyl acetate (87) | Burseraceae | Commiphora myrrh | 12 (NF54) | 2020[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year | ||||
|---|---|---|---|---|---|---|---|---|
| 4β-Hydroxy-11,12,13-trinor-5-eudesmen-1,7- dione (88) | Lamiaceae | Teucrium ramosissimum | 15.85±1.92 (FcB1) | 2009[ | ||||
| 1β,4β-Dihydroxy-11,12,13-trinor-8,9- eudesmen-7-one (89) | Lamiaceae | Teucrium ramosissimum | 89.88±1.43 (FcB1) | 2009[ | ||||
| 1β,4β,7α-Trihydroxy-8,9-eudesmene (90) | Lamiaceae | Teucrium ramosissimum | 64.47±5.11 (FcB1) | 2009[ | ||||
| 1β,4β,6β-Trihydroxyeudesmane (91) | Lamiaceae | Teucrium ramosissimum | 19.50±4.68 (FcB1) | 2009[ | ||||
| Corymbolone (92) | Cyperaceae | Cyperus articulatus | 4.53±0.34 (NF54) | 2008[ | ||||
| 8.12±0.25 (ENT36) | ||||||||
| Oplodiol (93) | Zingiberaceae | Reneilmia cincinnata | 17.49 (D6) | 1999[ | ||||
| 106.98 (W2) | ||||||||
| Kudtriol (94) | Asteraceae | Jasonia glutinosa | 58.28%, 250 μg•mL－1 (FCC2) | 2000[ | ||||
| 1β,6α-Dihydroxy-4(15)-eudesmene (95) | Asteraceae | Carpesium divaricatum | 42.1±2.1 (D10) | 2010[ | ||||
| β-Dictyopterol (96) | Asteraceae | Carpesium divaricatum | 13.1±0.8 (D10) | 2010[ | ||||
| Dobinin O (97) | Anacardiaceae | Dobinea delavayi | (17.8±13.3)%, 30 mg•kg－1•d－1 (P. yoelii) | 2020[ | ||||
| Dobinin K (98) | Anacardiaceae | Dobinea delavayi | 59.1%, 30 mg•kg－1•d－1 (P. yoelii) | 2020[ | ||||
| Dobinin N (99) | Anacardiaceae | Dobinea delavayi | 18.5%, 30 mg•kg－1•d－1 (P. yoelii) | 2020[ | ||||
| Dobinin E (100) | Anacardiaceae | Dobinea delavayi | 15.0%, 30 mg•kg－1•d－1 (P. yoelii) | 2020[ | ||||
| Dobinin F (101) | Anacardiaceae | Dobinea delavayi | 14.5%, 30 mg•kg－1•d－1 (P. yoelii) | 2020[ | ||||
| Dobinoside A (102) | Anacardiaceae | Dobinea delavayi | 6.4%, 25 mg•kg－1•d－1 (P. yoelii) | 2022[ | ||||
| Dobinin Q (103) | Anacardiaceae | Dobinea delavayi | 7.8%, 25 mg•kg－1•d－1 (P. yoelii) | 2022[ | ||||
| Dobinin R (104) | Anacardiaceae | Dobinea delavayi | 13.9%, 25 mg•kg－1•d－1 (P. yoelii) | 2022[ | ||||
| 9aβ-Hydroxy-4aαH-3,5α,8aβ-trimethyl- 4,4a,8a,9-tetrahydronaphtho-([2,3b]- dihydrofuran-2-one)-8-one (105) | Zingiberaceae | Siphonochilus aethiopicus | 69.12±5.95 (D10) | 2009[ | ||||
| 63.70±6.67 (K1) | ||||||||
| 4aαH-3,5α,8aβ-Trimethyl-4,4a,8a,9- tetrahydronaphtho-([2,3b]-dihydrofuran- 2-one)-8-one (106) | Zingiberaceae | Siphonochilus aethiopicus | 103.12±9.18 (D10) | 2009[ | ||||
| 23.79±1.50 (K1) | ||||||||
| 4aαH-3,5α,8aβ-Trimethyl-4,4a,8a- trihydronaphtho-([2,3b]-dihydrofuran-2- one)-8-one (107) | Zingiberaceae | Siphonochilus aethiopicus | 13.92±2.33 (D10) | 2009[ | ||||
| 7.16±1.35 (K1) | ||||||||
| Trilobolide 6-O-isobutyrate (108) | Asteraceae | Wedelia trilobata | 32.49 (PFB) | 2007[ | ||||
| Trilobolide 6-O-methacrylate (109) | Asteraceae | Wedelia trilobata | 19.76 (PFB) | 2007[ | ||||
| Desacetyl-β-cyclopyrethrosin (110) | Asteraceae | Oncosiphon piluliferum | 16.65 (D10) | 2007[ | ||||
| Sivasinolide (111) | Asteraceae | Oncosiphon piluliferum | 9.84 (D10) | 2007[ | ||||
| (―)-Oxyfrullanolide (112) | Asteraceae | Sphaeranthus indicus | 15.38 (K1) | 2016[ | ||||
| Dehydrobrachylaenolide (113) | Asteraceae | Dicoma anomala subsp. Gerrardii | 1.87±0.25 (D10) | 2011[ | ||||
| 4.10±0.58 (K1) | ||||||||
| Wedelolide A (114) | Asteraceae | Wedelia trilobata | 4.22 (PFB) | 2007[ | ||||
| Wedelolide B (115) | Asteraceae | Wedelia trilobata | 9.14 (PFB) | 2007[ | ||||
| Wedelolide G (116) | Asteraceae | Wedelia trilobata | 3.42 (PFB) | 2016[ | ||||
| Wedelolide H (117) | Asteraceae | Wedelia trilobata | 5.96 (PFB) | 2016[ | ||||
| Indicusalactone (118) | Asteraceae | Sphaeranthus indicus | 10.94 (K1) | 2016[ | ||||
| Salaterpene A (119) | Celastraceae | Salacia longipes | 2.02±0.25 (W2) | 2013[ | ||||
| Salaterpene B (120) | Celastraceae | Salacia longipes | 1.81±0.15 (W2) | 2013[ | ||||
| Salaterpene C (121) | Celastraceae | Salacia longipes | 2.63±0.12 (W2) | 2013[ | ||||
| Salaterpene D (122) | Celastraceae | Salacia longipes | 2.38±0.42 (W2) | 2013[ | ||||
| 2β-Acetoxy-1α,6β,9β-tribenzoyloxy- 4β-hydroxy-dihydro-β-garofuran (123) | Celastraceae | Salacia longipes | 1.71±0.06 (W2) | 2013[ | ||||
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year | ||||
|---|---|---|---|---|---|---|---|---|
| 4β-Hydroxy-11,12,13-trinor-5-eudesmen-1,7- dione (88) | Lamiaceae | Teucrium ramosissimum | 15.85±1.92 (FcB1) | 2009[ | ||||
| 1β,4β-Dihydroxy-11,12,13-trinor-8,9- eudesmen-7-one (89) | Lamiaceae | Teucrium ramosissimum | 89.88±1.43 (FcB1) | 2009[ | ||||
| 1β,4β,7α-Trihydroxy-8,9-eudesmene (90) | Lamiaceae | Teucrium ramosissimum | 64.47±5.11 (FcB1) | 2009[ | ||||
| 1β,4β,6β-Trihydroxyeudesmane (91) | Lamiaceae | Teucrium ramosissimum | 19.50±4.68 (FcB1) | 2009[ | ||||
| Corymbolone (92) | Cyperaceae | Cyperus articulatus | 4.53±0.34 (NF54) | 2008[ | ||||
| 8.12±0.25 (ENT36) | ||||||||
| Oplodiol (93) | Zingiberaceae | Reneilmia cincinnata | 17.49 (D6) | 1999[ | ||||
| 106.98 (W2) | ||||||||
| Kudtriol (94) | Asteraceae | Jasonia glutinosa | 58.28%, 250 μg•mL－1 (FCC2) | 2000[ | ||||
| 1β,6α-Dihydroxy-4(15)-eudesmene (95) | Asteraceae | Carpesium divaricatum | 42.1±2.1 (D10) | 2010[ | ||||
| β-Dictyopterol (96) | Asteraceae | Carpesium divaricatum | 13.1±0.8 (D10) | 2010[ | ||||
| Dobinin O (97) | Anacardiaceae | Dobinea delavayi | (17.8±13.3)%, 30 mg•kg－1•d－1 (P. yoelii) | 2020[ | ||||
| Dobinin K (98) | Anacardiaceae | Dobinea delavayi | 59.1%, 30 mg•kg－1•d－1 (P. yoelii) | 2020[ | ||||
| Dobinin N (99) | Anacardiaceae | Dobinea delavayi | 18.5%, 30 mg•kg－1•d－1 (P. yoelii) | 2020[ | ||||
| Dobinin E (100) | Anacardiaceae | Dobinea delavayi | 15.0%, 30 mg•kg－1•d－1 (P. yoelii) | 2020[ | ||||
| Dobinin F (101) | Anacardiaceae | Dobinea delavayi | 14.5%, 30 mg•kg－1•d－1 (P. yoelii) | 2020[ | ||||
| Dobinoside A (102) | Anacardiaceae | Dobinea delavayi | 6.4%, 25 mg•kg－1•d－1 (P. yoelii) | 2022[ | ||||
| Dobinin Q (103) | Anacardiaceae | Dobinea delavayi | 7.8%, 25 mg•kg－1•d－1 (P. yoelii) | 2022[ | ||||
| Dobinin R (104) | Anacardiaceae | Dobinea delavayi | 13.9%, 25 mg•kg－1•d－1 (P. yoelii) | 2022[ | ||||
| 9aβ-Hydroxy-4aαH-3,5α,8aβ-trimethyl- 4,4a,8a,9-tetrahydronaphtho-([2,3b]- dihydrofuran-2-one)-8-one (105) | Zingiberaceae | Siphonochilus aethiopicus | 69.12±5.95 (D10) | 2009[ | ||||
| 63.70±6.67 (K1) | ||||||||
| 4aαH-3,5α,8aβ-Trimethyl-4,4a,8a,9- tetrahydronaphtho-([2,3b]-dihydrofuran- 2-one)-8-one (106) | Zingiberaceae | Siphonochilus aethiopicus | 103.12±9.18 (D10) | 2009[ | ||||
| 23.79±1.50 (K1) | ||||||||
| 4aαH-3,5α,8aβ-Trimethyl-4,4a,8a- trihydronaphtho-([2,3b]-dihydrofuran-2- one)-8-one (107) | Zingiberaceae | Siphonochilus aethiopicus | 13.92±2.33 (D10) | 2009[ | ||||
| 7.16±1.35 (K1) | ||||||||
| Trilobolide 6-O-isobutyrate (108) | Asteraceae | Wedelia trilobata | 32.49 (PFB) | 2007[ | ||||
| Trilobolide 6-O-methacrylate (109) | Asteraceae | Wedelia trilobata | 19.76 (PFB) | 2007[ | ||||
| Desacetyl-β-cyclopyrethrosin (110) | Asteraceae | Oncosiphon piluliferum | 16.65 (D10) | 2007[ | ||||
| Sivasinolide (111) | Asteraceae | Oncosiphon piluliferum | 9.84 (D10) | 2007[ | ||||
| (―)-Oxyfrullanolide (112) | Asteraceae | Sphaeranthus indicus | 15.38 (K1) | 2016[ | ||||
| Dehydrobrachylaenolide (113) | Asteraceae | Dicoma anomala subsp. Gerrardii | 1.87±0.25 (D10) | 2011[ | ||||
| 4.10±0.58 (K1) | ||||||||
| Wedelolide A (114) | Asteraceae | Wedelia trilobata | 4.22 (PFB) | 2007[ | ||||
| Wedelolide B (115) | Asteraceae | Wedelia trilobata | 9.14 (PFB) | 2007[ | ||||
| Wedelolide G (116) | Asteraceae | Wedelia trilobata | 3.42 (PFB) | 2016[ | ||||
| Wedelolide H (117) | Asteraceae | Wedelia trilobata | 5.96 (PFB) | 2016[ | ||||
| Indicusalactone (118) | Asteraceae | Sphaeranthus indicus | 10.94 (K1) | 2016[ | ||||
| Salaterpene A (119) | Celastraceae | Salacia longipes | 2.02±0.25 (W2) | 2013[ | ||||
| Salaterpene B (120) | Celastraceae | Salacia longipes | 1.81±0.15 (W2) | 2013[ | ||||
| Salaterpene C (121) | Celastraceae | Salacia longipes | 2.63±0.12 (W2) | 2013[ | ||||
| Salaterpene D (122) | Celastraceae | Salacia longipes | 2.38±0.42 (W2) | 2013[ | ||||
| 2β-Acetoxy-1α,6β,9β-tribenzoyloxy- 4β-hydroxy-dihydro-β-garofuran (123) | Celastraceae | Salacia longipes | 1.71±0.06 (W2) | 2013[ | ||||
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Oxyonoseriolide (124) | Chloranthaceae | Hedyosmum angustifolium | 107.7±1.3 (FcB1) | 2010[ |
| Onoseriolide (125) | Chloranthaceae | Hedyosmum angustifolium | 12.5±0.1 (FcB1) | 2010[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Oxyonoseriolide (124) | Chloranthaceae | Hedyosmum angustifolium | 107.7±1.3 (FcB1) | 2010[ |
| Onoseriolide (125) | Chloranthaceae | Hedyosmum angustifolium | 12.5±0.1 (FcB1) | 2010[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| 1-β-(p-Methoxycinnamoyl)-polyg odial (126) | Winteraceae | Drimys brasiliensis | 4.87±0.97 (FcR3) | 2013[ |
| 1-β-(p-Cumaroyloxyl)-polygodial (127) | Winteraceae | Drimys brasiliensis | 1.01±0.10 (FcR3) | 2013[ |
| Iso-mukaadial acetate (128) | Canellaceae | Warburgia salutaris | 1.43±0.32 (NF54) | 2018[ |
| 3-β-Acetoxypolygodial (129) | Canellaceae | Canella winterana | 9.47±0.51 (D10) | 2010[ |
| 9-Epideoxymuzigadial (130) | Canellaceae | Canella winterana | 4.35±0.26 (D10) | 2010[ |
| 9-Deoxymuzigadial (131) | Canellaceae | Canella winterana | 9.43±0.34 (D10) | 2010[ |
| Muzigadial (132) | Canellaceae | Canella winterana | 1.25±0.08 (D10) | 2010[ |
| Muzigodiol (133) | Canellaceae | Canella winterana | 29.68±2.40 (D10) | 2010[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| 1-β-(p-Methoxycinnamoyl)-polyg odial (126) | Winteraceae | Drimys brasiliensis | 4.87±0.97 (FcR3) | 2013[ |
| 1-β-(p-Cumaroyloxyl)-polygodial (127) | Winteraceae | Drimys brasiliensis | 1.01±0.10 (FcR3) | 2013[ |
| Iso-mukaadial acetate (128) | Canellaceae | Warburgia salutaris | 1.43±0.32 (NF54) | 2018[ |
| 3-β-Acetoxypolygodial (129) | Canellaceae | Canella winterana | 9.47±0.51 (D10) | 2010[ |
| 9-Epideoxymuzigadial (130) | Canellaceae | Canella winterana | 4.35±0.26 (D10) | 2010[ |
| 9-Deoxymuzigadial (131) | Canellaceae | Canella winterana | 9.43±0.34 (D10) | 2010[ |
| Muzigadial (132) | Canellaceae | Canella winterana | 1.25±0.08 (D10) | 2010[ |
| Muzigodiol (133) | Canellaceae | Canella winterana | 29.68±2.40 (D10) | 2010[ |
| Compd. | Family | Plant | IC50 or EC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Artemisinin (134) | Asteraceae | Artemisia annua | <0.01 | 1984[ |
| Asteraceae | Artemisia annua | 0.04 (FCH5) | 1991[ | |
| Oxo-T-cadinol (135) | Lamiaceae | Teucrium ramosissimum | 18.62±2.54 (FcB1) | 2009[ |
| 10,12-Peroxycalamenene (136) | Cyperaceae | Cyperus rotundus | 2.33 (K1) | 1995[ |
| 4,7-Dimethyl-1-tetralone (137) | Cyperaceae | Cyperus rotundus | 86.2 (K1) | 1995[ |
| Myrrhone (138) | Burseraceae | Commiphora myrrh | 21 (NF54) | 2020[ |
| Compd. | Family | Plant | IC50 or EC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Artemisinin (134) | Asteraceae | Artemisia annua | <0.01 | 1984[ |
| Asteraceae | Artemisia annua | 0.04 (FCH5) | 1991[ | |
| Oxo-T-cadinol (135) | Lamiaceae | Teucrium ramosissimum | 18.62±2.54 (FcB1) | 2009[ |
| 10,12-Peroxycalamenene (136) | Cyperaceae | Cyperus rotundus | 2.33 (K1) | 1995[ |
| 4,7-Dimethyl-1-tetralone (137) | Cyperaceae | Cyperus rotundus | 86.2 (K1) | 1995[ |
| Myrrhone (138) | Burseraceae | Commiphora myrrh | 21 (NF54) | 2020[ |
| Compd. | Family | Plant | EC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Nardosinon (139) | Valerianaceae | Nardostachys chinensis | 5.59 (FCH5) | 1991[ |
| Nardosinone (140) | Valerianaceae | Nardostachys chinensis | 4.50 | 1998[ |
| Compd. | Family | Plant | EC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Nardosinon (139) | Valerianaceae | Nardostachys chinensis | 5.59 (FCH5) | 1991[ |
| Nardosinone (140) | Valerianaceae | Nardostachys chinensis | 4.50 | 1998[ |
| Compd. | Family | Plant | IC50 or EC50/(μmol•L－1) | Year | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cynaropicrin (141) | Asteraceae | Vernonia mespilifolia | 1.56 (NF54) | 2013[ | ||||||
| Gorgonolide (142) | Asteraceae | Artemisia gorgonum | 59.09±28.97 (FcB1) | 2008[ | ||||||
| 1β,10α-Dihydroxy-1,10-deoxygorgonolide (143) | Asteraceae | Artemisia gorgonum | 68.49±8.92 (FcB1) | 2008[ | ||||||
| 3β,4β-Epoxy-1β,10β-epiarborescin (144) | Asteraceae | Artemisia gorgonum | 50.32±14.38 (FcB1) | 2008[ | ||||||
| Arborescin (145) | Asteraceae | Artemisia gorgonum | 15.30±2.82 (FcB1) | 2008[ | ||||||
| 1β,10β-Epoxy-2α-hydroxykauniolide (146) | Asteraceae | Artemisia gorgonum | 22.11±5.72 (FcB1) | 2008[ | ||||||
| 1α,4α,10α-Trihydroxy-5α,11βH-guaia-2-en- 12,6α-olide (147) | Asteraceae | Artemisia gorgonum | 30.68±7.13 (FcB1) | 2008[ | ||||||
| α-Peroxyachifolid (148) | Asteraceae | Achillea milefolium | 2.66 (FCH5) | 1991[ | ||||||
| Parthenin (149) | Asteraceae | Parthenium hysterophorus L | 4.91 (K1) | 1990[ | ||||||
| 1,10-Dioxo-1,10-deoxy-1,10-secogorgonolide (150) | Asteraceae | Vernoniopsis caudata | 44.92±8.98 (FcB1) | 2008[ | ||||||
| Helenalin-[2-(1-hydroxyethyl)acrylate] (151) | Asteraceae | Vernoniopsis caudata | 1.00±0.28 (FcB1) | 2005[ | ||||||
| Helenalin-[(2-hydroxyethyl-3-methyl)acrylate] (152) | Asteraceae | Vernoniopsis caudata | 0.19±0.04 (FcB1) | 2005[ | ||||||
| 11α,13-Dihydrohelenalin-[2-(1-hydroxyethyl)- acrylate] (153) | Asteraceae | Vernoniopsis caudata | 0.41±0.07 (FcB1) | 2005[ | ||||||
| Helenalin (154) | Asteraceae | Arnica montana | 0.23 (NF54) | 2004[ | ||||||
| Helenalinacetate (155) | Asteraceae | Arnica montana | 2.43 (NF54) | 2004[ | ||||||
| Dihydrohelenalin (156) | Asteraceae | Arnica montana | 5.14 (NF54) | 2004[ | ||||||
| Dihydrohelenalinacetate (157) | Asteraceae | Arnica montana | 7.41 (NF54) | 2004[ | ||||||
| Brevilin A (158) | Asteraceae | Centipeda minima | 9.41±2.57 (K1) | 1994[ | ||||||
| Carpesiolin (159) | Asteraceae | Carpesium cernum | 61.67 (D10) | 2009[ | ||||||
| Athrolide A (160) | Asteraceae | Athroisma proteiforme | 34.3±0.3 (HB3) | 2011[ | ||||||
| 32.7±0.3 (Dd2) | ||||||||||
| Athrolide C (161) | Asteraceae | Athroisma proteiforme | 6.6±0.1 (HB3) | 2011[ | ||||||
| 5.5±0.03 (Dd2) | ||||||||||
| Athrolide D (162) | Asteraceae | Athroisma proteiforme | 7.2±0.2 (HB3) | 2011[ | ||||||
| 4.2±0.7 (Dd2) | ||||||||||
| Athrolide E (163) | Asteraceae | Athroisma proteiforme | 16.0±0.3 (HB3) | 2011[ | ||||||
| 11.7±0.3 (Dd2) | ||||||||||
| 8-Epixanthatin (164) | Asteraceae | Xanthium brasilicum | 7.83 (K1) | 2009[ | ||||||
| 8-Epixanthatin 1β,5β-epoxide (165) | Asteraceae | Xanthium brasilicum | 6.51 (K1) | 2009[ | ||||||
| Xanthinosin (166) | Asteraceae | Xanthium strumarium L | 27.25±0.86 (3D7) | 2020[ | ||||||
| Myrrhterpenoid O (167) | Burseraceae | Commiphora myrrh | 21 (NF54) | 2020[ | ||||||
| Nardoguaianone A (168) | Valerianaceae | Nardostachys chinensis | 4.1 | 2000[ | ||||||
| Nardoguaianone B (169) | Valerianaceae | Nardostachys chinensis | 5.3 | 2000[ | ||||||
| Nardoguaianone C (170) | Valerianaceae | Nardostachys chinensis | 9.0 | 2000[ | ||||||
| Nardoguaianone D (171) | Valerianaceae | Nardostachys chinensis | 4.1 | 2000[ | ||||||
| Nardoperoxide (172) | Valerianaceae | Nardostachys chinensis | 1.5 | 1998[ | ||||||
| Isonardoperoxide (173) | Valerianaceae | Nardostachys chinensis | 0.6 | 1998[ | ||||||
| Patchoulenone (174) | Cyperaceae | Cyperus rotundus | 108 (K1) | 1995[ | ||||||
| Compd. | Family | Plant | IC50 or EC50/(μmol•L－1) | Year | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cynaropicrin (141) | Asteraceae | Vernonia mespilifolia | 1.56 (NF54) | 2013[ | ||||||
| Gorgonolide (142) | Asteraceae | Artemisia gorgonum | 59.09±28.97 (FcB1) | 2008[ | ||||||
| 1β,10α-Dihydroxy-1,10-deoxygorgonolide (143) | Asteraceae | Artemisia gorgonum | 68.49±8.92 (FcB1) | 2008[ | ||||||
| 3β,4β-Epoxy-1β,10β-epiarborescin (144) | Asteraceae | Artemisia gorgonum | 50.32±14.38 (FcB1) | 2008[ | ||||||
| Arborescin (145) | Asteraceae | Artemisia gorgonum | 15.30±2.82 (FcB1) | 2008[ | ||||||
| 1β,10β-Epoxy-2α-hydroxykauniolide (146) | Asteraceae | Artemisia gorgonum | 22.11±5.72 (FcB1) | 2008[ | ||||||
| 1α,4α,10α-Trihydroxy-5α,11βH-guaia-2-en- 12,6α-olide (147) | Asteraceae | Artemisia gorgonum | 30.68±7.13 (FcB1) | 2008[ | ||||||
| α-Peroxyachifolid (148) | Asteraceae | Achillea milefolium | 2.66 (FCH5) | 1991[ | ||||||
| Parthenin (149) | Asteraceae | Parthenium hysterophorus L | 4.91 (K1) | 1990[ | ||||||
| 1,10-Dioxo-1,10-deoxy-1,10-secogorgonolide (150) | Asteraceae | Vernoniopsis caudata | 44.92±8.98 (FcB1) | 2008[ | ||||||
| Helenalin-[2-(1-hydroxyethyl)acrylate] (151) | Asteraceae | Vernoniopsis caudata | 1.00±0.28 (FcB1) | 2005[ | ||||||
| Helenalin-[(2-hydroxyethyl-3-methyl)acrylate] (152) | Asteraceae | Vernoniopsis caudata | 0.19±0.04 (FcB1) | 2005[ | ||||||
| 11α,13-Dihydrohelenalin-[2-(1-hydroxyethyl)- acrylate] (153) | Asteraceae | Vernoniopsis caudata | 0.41±0.07 (FcB1) | 2005[ | ||||||
| Helenalin (154) | Asteraceae | Arnica montana | 0.23 (NF54) | 2004[ | ||||||
| Helenalinacetate (155) | Asteraceae | Arnica montana | 2.43 (NF54) | 2004[ | ||||||
| Dihydrohelenalin (156) | Asteraceae | Arnica montana | 5.14 (NF54) | 2004[ | ||||||
| Dihydrohelenalinacetate (157) | Asteraceae | Arnica montana | 7.41 (NF54) | 2004[ | ||||||
| Brevilin A (158) | Asteraceae | Centipeda minima | 9.41±2.57 (K1) | 1994[ | ||||||
| Carpesiolin (159) | Asteraceae | Carpesium cernum | 61.67 (D10) | 2009[ | ||||||
| Athrolide A (160) | Asteraceae | Athroisma proteiforme | 34.3±0.3 (HB3) | 2011[ | ||||||
| 32.7±0.3 (Dd2) | ||||||||||
| Athrolide C (161) | Asteraceae | Athroisma proteiforme | 6.6±0.1 (HB3) | 2011[ | ||||||
| 5.5±0.03 (Dd2) | ||||||||||
| Athrolide D (162) | Asteraceae | Athroisma proteiforme | 7.2±0.2 (HB3) | 2011[ | ||||||
| 4.2±0.7 (Dd2) | ||||||||||
| Athrolide E (163) | Asteraceae | Athroisma proteiforme | 16.0±0.3 (HB3) | 2011[ | ||||||
| 11.7±0.3 (Dd2) | ||||||||||
| 8-Epixanthatin (164) | Asteraceae | Xanthium brasilicum | 7.83 (K1) | 2009[ | ||||||
| 8-Epixanthatin 1β,5β-epoxide (165) | Asteraceae | Xanthium brasilicum | 6.51 (K1) | 2009[ | ||||||
| Xanthinosin (166) | Asteraceae | Xanthium strumarium L | 27.25±0.86 (3D7) | 2020[ | ||||||
| Myrrhterpenoid O (167) | Burseraceae | Commiphora myrrh | 21 (NF54) | 2020[ | ||||||
| Nardoguaianone A (168) | Valerianaceae | Nardostachys chinensis | 4.1 | 2000[ | ||||||
| Nardoguaianone B (169) | Valerianaceae | Nardostachys chinensis | 5.3 | 2000[ | ||||||
| Nardoguaianone C (170) | Valerianaceae | Nardostachys chinensis | 9.0 | 2000[ | ||||||
| Nardoguaianone D (171) | Valerianaceae | Nardostachys chinensis | 4.1 | 2000[ | ||||||
| Nardoperoxide (172) | Valerianaceae | Nardostachys chinensis | 1.5 | 1998[ | ||||||
| Isonardoperoxide (173) | Valerianaceae | Nardostachys chinensis | 0.6 | 1998[ | ||||||
| Patchoulenone (174) | Cyperaceae | Cyperus rotundus | 108 (K1) | 1995[ | ||||||
| Compd. | Family | Plant | IC50 or EC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| β-Caryophyllene (176) | Rutaceae | Murraya koenigii | 40.37±0.98 (3D7) | 2014[ |
| (88.2±0.69)%, 100 mg•kg－1•d－1 (P. berghei) | ||||
| Caryophyllene oxide (177) | Annonaceae | Polyalthia cerasoides | 12.71 (K1) | 2007[ |
| Caryophyllene α-oxide (178) | Cyperaceae | Cyperus rotundus | 345 (K1) | 1995[ |
| Compd. | Family | Plant | IC50 or EC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| β-Caryophyllene (176) | Rutaceae | Murraya koenigii | 40.37±0.98 (3D7) | 2014[ |
| (88.2±0.69)%, 100 mg•kg－1•d－1 (P. berghei) | ||||
| Caryophyllene oxide (177) | Annonaceae | Polyalthia cerasoides | 12.71 (K1) | 2007[ |
| Caryophyllene α-oxide (178) | Cyperaceae | Cyperus rotundus | 345 (K1) | 1995[ |
| Compd. | Family | Plant | IC50/(nmol•L－1) | Year |
|---|---|---|---|---|
| Verrucarin L acetate (179) | Moraceae | Ficus fistulosa | 1.11±0.07 (D6) | 2002[ |
| 1.29±0.09 (W2) | ||||
| Roridin E (180) | Moraceae | Ficus fistulosa | 0.39±0.16 (D6) | 2002[ |
| 1.17±0.21 (W2) | ||||
| Satratoxin H (181) | Moraceae | Ficus fistulosa | 1.51±0.08 (D6) | 2002[ |
| 1.51±0.04 (W2) | ||||
| Satratoxin H 13'-acetate (182) | Moraceae | Ficus fistulosa | 2.28±0.05 (D6) | 2002[ |
| 3.33±0.47 (W2) | ||||
| Satratoxin H 12',13'-diacetate (183) | Moraceae | Ficus fistulosa | 6.04±0.77 (D6) | 2002[ |
| 8.81±1.31 (W2) |
| Compd. | Family | Plant | IC50/(nmol•L－1) | Year |
|---|---|---|---|---|
| Verrucarin L acetate (179) | Moraceae | Ficus fistulosa | 1.11±0.07 (D6) | 2002[ |
| 1.29±0.09 (W2) | ||||
| Roridin E (180) | Moraceae | Ficus fistulosa | 0.39±0.16 (D6) | 2002[ |
| 1.17±0.21 (W2) | ||||
| Satratoxin H (181) | Moraceae | Ficus fistulosa | 1.51±0.08 (D6) | 2002[ |
| 1.51±0.04 (W2) | ||||
| Satratoxin H 13'-acetate (182) | Moraceae | Ficus fistulosa | 2.28±0.05 (D6) | 2002[ |
| 3.33±0.47 (W2) | ||||
| Satratoxin H 12',13'-diacetate (183) | Moraceae | Ficus fistulosa | 6.04±0.77 (D6) | 2002[ |
| 8.81±1.31 (W2) |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Anthecularin (184) | Asteraceae | Anastasia Karioti | 94.60 (K1) | 2007[ |
| Okundoperoxide (185) | Cyperaceae | Scleria striatinux | 1.76 (W2) | 2009[ |
| 4.91 (NF54) | ||||
| 1.81 (D6) | ||||
| 5.62 (K1) | ||||
| Paulitin (186) | Asteraceae | Ambrosia artemisiaefolia | 22.04 (W2) | 1999[ |
| 24.11 (D6) | ||||
| Isopaulitin (187) | Asteraceae | Ambrosia artemisiaefolia | 19.98 (W2) | 1999[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Anthecularin (184) | Asteraceae | Anastasia Karioti | 94.60 (K1) | 2007[ |
| Okundoperoxide (185) | Cyperaceae | Scleria striatinux | 1.76 (W2) | 2009[ |
| 4.91 (NF54) | ||||
| 1.81 (D6) | ||||
| 5.62 (K1) | ||||
| Paulitin (186) | Asteraceae | Ambrosia artemisiaefolia | 22.04 (W2) | 1999[ |
| 24.11 (D6) | ||||
| Isopaulitin (187) | Asteraceae | Ambrosia artemisiaefolia | 19.98 (W2) | 1999[ |
| Compd. | Family | Plant | Inhibition/% | Year |
|---|---|---|---|---|
| Dodelate A (188) | Anacardiaceae | Dobinea delavayi | 23.3, 50 mg•kg－1•d－1 (P. yoelii) | 2020[ |
| Dodelate B (189) | Anacardiaceae | Dobinea delavayi | 15.2, 50 mg•kg－1•d－1 (P. yoelii) | 2020[ |
| Dodelate C (190) | Anacardiaceae | Dobinea delavayi | 28.9, 50 mg•kg－1•d－1 (P. yoelii) | 2020[ |
| Dodelate D (191) | Anacardiaceae | Dobinea delavayi | 14.4, 50 mg• kg－1•d－1 (P. yoelii) | 2020[ |
| Compd. | Family | Plant | Inhibition/% | Year |
|---|---|---|---|---|
| Dodelate A (188) | Anacardiaceae | Dobinea delavayi | 23.3, 50 mg•kg－1•d－1 (P. yoelii) | 2020[ |
| Dodelate B (189) | Anacardiaceae | Dobinea delavayi | 15.2, 50 mg•kg－1•d－1 (P. yoelii) | 2020[ |
| Dodelate C (190) | Anacardiaceae | Dobinea delavayi | 28.9, 50 mg•kg－1•d－1 (P. yoelii) | 2020[ |
| Dodelate D (191) | Anacardiaceae | Dobinea delavayi | 14.4, 50 mg• kg－1•d－1 (P. yoelii) | 2020[ |
| Compd. | Family | Plant | IC50 or EC50/(nmol•L－1) | Year |
|---|---|---|---|---|
| Fortunilide A (192) | Chloranthaceae | Chloranthus fortunei | 5.2±0.6 (Dd2) | 2017[ |
| Fortunilide B (193) | Chloranthaceae | Chloranthus fortunei | 19±8 (Dd2) | 2017[ |
| Fortunilide C (194) | Chloranthaceae | Chloranthus fortunei | 211±56 (Dd2) | 2017[ |
| Sarglabolide I (195) | Chloranthaceae | Chloranthus fortunei | 4600±200 (Dd2) | 2017[ |
| Sarglabolide J (196) | Chloranthaceae | Chloranthus fortunei | 7.2±1.3 (Dd2) | 2017[ |
| Shizukaol C (197) | Chloranthaceae | Chloranthus fortunei | 21±9 (Dd2) | 2017[ |
| Shizukaol I (198) | Chloranthaceae | Chloranthus fortunei | 111±12 (Dd2) | 2017[ |
| Shizukaol K (199) | Chloranthaceae | Chloranthus fortunei | 860±89 (Dd2) | 2017[ |
| Schizukaol M (200) | Chloranthaceae | Chloranthus fortunei | 96±37 (Dd2) | 2017[ |
| Chlorahololide D (201) | Chloranthaceae | Chloranthus fortunei | 13±3 (Dd2) | 2017[ |
| Chlorajaponilide C (202) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 1.1±0.2 (Dd2) | 2017[ |
| Chloranthaceae | Chloranthecae spp | 0.77±0.05 (3D7) | 2020[ | |
| Shizukaol D (203) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 580±90 (Dd2) | 2017[ |
| Shizukaol E (204) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 1800±400 (Dd2) | 2017[ |
| Shizukaol N (205) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 100±10 (Dd2) | 2017[ |
| Sarcandrolide A (206) | Chloranthaceae | Sarcandra glabra | 320±130 (Dd2) | 2017[ |
| Sarcandrolide B (207) | Chloranthaceae | Sarcandra glabra | 265±5 (Dd2) | 2017[ |
| Sarcandrolide J (208) | Chloranthaceae | Sarcandra glabra | 11400±1600 (Dd2) | 2017[ |
| 13'-O-Methyl succinylshizukaol C (209) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 0.0043±0.0003 (Dd2) | 2022[ |
| 4"-Hydroxysarcandrolide A (210) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 36±8 (Dd2) | 2022[ |
| 13'-O-Acetylsarcandrolide B (211) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 85±1 (Dd2) | 2022[ |
| Fortunilide D (212) | Chloranthaceae | Chloranthus fortunei | 30±8 (Dd2) | 2017[ |
| Fortunilide E (213) | Chloranthaceae | Chloranthus fortunei | 43±3 (Dd2) | 2017[ |
| Fortunilide F (214) | Chloranthaceae | Chloranthus fortunei | 5300±2000 (Dd2) | 2017[ |
| 13'-O-Methyl succinylchlora- japonilide E (215) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 60±10 (Dd2) | 2022[ |
| Fortunilide G (216) | Chloranthaceae | Chloranthus fortunei | 46±3 (Dd2) | 2017[ |
| Shizukaol F (217) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 11±1 (Dd2) | 2017[ |
| Fortunilide H (218) | Chloranthaceae | Chloranthus fortunei | 198±22 (Dd2) | 2017[ |
| Fortunilide I (219) | Chloranthaceae | Chloranthus fortunei | 94±30 (Dd2) | 2017[ |
| Fortunilide J (220) | Chloranthaceae | Chloranthus fortunei | 9900±2700 (Dd2) | 2017[ |
| Fortunoid A (221) | Chloranthaceae | Chloranthus fortunei | 10200±370 (Dd2) | 2017[ |
| Shizukaol A (222) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 1500±300 (Dd2) | 2017[ |
| Shizukaol B (223) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 27±3 (Dd2) | 2017[ |
| Shizukaol G (224) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 13±1 (Dd2) | 2017[ |
| Chloramultilide B (225) | Chloranthaceae | Chloranthus multisachys | 7100±1000 (Dd2) | 2017[ |
| Sarglabolide C (226) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 9.7±1.3 (Dd2) | 2022[ |
| Henriol C (227) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 102±8 (Dd2) | 2022[ |
| Fortunilide K (228) | Chloranthaceae | Chloranthus fortunei | 4700±500 (Dd2) | 2017[ |
| Fortunilide L (229) | Chloranthaceae | Chloranthus fortunei | 99±18 (Dd2) | 2017[ |
| Compd. | Family | Plant | IC50 or EC50/(nmol•L－1) | Year |
|---|---|---|---|---|
| Fortunilide A (192) | Chloranthaceae | Chloranthus fortunei | 5.2±0.6 (Dd2) | 2017[ |
| Fortunilide B (193) | Chloranthaceae | Chloranthus fortunei | 19±8 (Dd2) | 2017[ |
| Fortunilide C (194) | Chloranthaceae | Chloranthus fortunei | 211±56 (Dd2) | 2017[ |
| Sarglabolide I (195) | Chloranthaceae | Chloranthus fortunei | 4600±200 (Dd2) | 2017[ |
| Sarglabolide J (196) | Chloranthaceae | Chloranthus fortunei | 7.2±1.3 (Dd2) | 2017[ |
| Shizukaol C (197) | Chloranthaceae | Chloranthus fortunei | 21±9 (Dd2) | 2017[ |
| Shizukaol I (198) | Chloranthaceae | Chloranthus fortunei | 111±12 (Dd2) | 2017[ |
| Shizukaol K (199) | Chloranthaceae | Chloranthus fortunei | 860±89 (Dd2) | 2017[ |
| Schizukaol M (200) | Chloranthaceae | Chloranthus fortunei | 96±37 (Dd2) | 2017[ |
| Chlorahololide D (201) | Chloranthaceae | Chloranthus fortunei | 13±3 (Dd2) | 2017[ |
| Chlorajaponilide C (202) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 1.1±0.2 (Dd2) | 2017[ |
| Chloranthaceae | Chloranthecae spp | 0.77±0.05 (3D7) | 2020[ | |
| Shizukaol D (203) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 580±90 (Dd2) | 2017[ |
| Shizukaol E (204) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 1800±400 (Dd2) | 2017[ |
| Shizukaol N (205) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 100±10 (Dd2) | 2017[ |
| Sarcandrolide A (206) | Chloranthaceae | Sarcandra glabra | 320±130 (Dd2) | 2017[ |
| Sarcandrolide B (207) | Chloranthaceae | Sarcandra glabra | 265±5 (Dd2) | 2017[ |
| Sarcandrolide J (208) | Chloranthaceae | Sarcandra glabra | 11400±1600 (Dd2) | 2017[ |
| 13'-O-Methyl succinylshizukaol C (209) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 0.0043±0.0003 (Dd2) | 2022[ |
| 4"-Hydroxysarcandrolide A (210) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 36±8 (Dd2) | 2022[ |
| 13'-O-Acetylsarcandrolide B (211) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 85±1 (Dd2) | 2022[ |
| Fortunilide D (212) | Chloranthaceae | Chloranthus fortunei | 30±8 (Dd2) | 2017[ |
| Fortunilide E (213) | Chloranthaceae | Chloranthus fortunei | 43±3 (Dd2) | 2017[ |
| Fortunilide F (214) | Chloranthaceae | Chloranthus fortunei | 5300±2000 (Dd2) | 2017[ |
| 13'-O-Methyl succinylchlora- japonilide E (215) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 60±10 (Dd2) | 2022[ |
| Fortunilide G (216) | Chloranthaceae | Chloranthus fortunei | 46±3 (Dd2) | 2017[ |
| Shizukaol F (217) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 11±1 (Dd2) | 2017[ |
| Fortunilide H (218) | Chloranthaceae | Chloranthus fortunei | 198±22 (Dd2) | 2017[ |
| Fortunilide I (219) | Chloranthaceae | Chloranthus fortunei | 94±30 (Dd2) | 2017[ |
| Fortunilide J (220) | Chloranthaceae | Chloranthus fortunei | 9900±2700 (Dd2) | 2017[ |
| Fortunoid A (221) | Chloranthaceae | Chloranthus fortunei | 10200±370 (Dd2) | 2017[ |
| Shizukaol A (222) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 1500±300 (Dd2) | 2017[ |
| Shizukaol B (223) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 27±3 (Dd2) | 2017[ |
| Shizukaol G (224) | Chloranthaceae | Chloranthus serratus/Chloranthus spicatus | 13±1 (Dd2) | 2017[ |
| Chloramultilide B (225) | Chloranthaceae | Chloranthus multisachys | 7100±1000 (Dd2) | 2017[ |
| Sarglabolide C (226) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 9.7±1.3 (Dd2) | 2022[ |
| Henriol C (227) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 102±8 (Dd2) | 2022[ |
| Fortunilide K (228) | Chloranthaceae | Chloranthus fortunei | 4700±500 (Dd2) | 2017[ |
| Fortunilide L (229) | Chloranthaceae | Chloranthus fortunei | 99±18 (Dd2) | 2017[ |
| Compd. | Family | Plant | IC50 or EC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Fortunoid B (230) | Chloranthaceae | Chloranthus fortunei | 0.5±0.01 (Dd2) | 2017[ |
| 15'-O-(4-Hydroxytigloyl)fortunoid C (231) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 1.5±0.01 (Dd2) | 2022[ |
| Compd. | Family | Plant | IC50 or EC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Fortunoid B (230) | Chloranthaceae | Chloranthus fortunei | 0.5±0.01 (Dd2) | 2017[ |
| 15'-O-(4-Hydroxytigloyl)fortunoid C (231) | Chloranthaceae | Sarcandra glabra subsp. brachystachys | 1.5±0.01 (Dd2) | 2022[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Pungiolide A (232) | Asteraceae | Xanthium brasilicum | 4.96 (K1) | 2009[ |
| Pungiolide B (233) | Asteraceae | Xanthium brasilicum | 6.53 (K1) | 2009[ |
| Diguaiaperfolin (234) | Asteraceae | Eupatorium perfoliatum | 2.0 | 2011[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Pungiolide A (232) | Asteraceae | Xanthium brasilicum | 4.96 (K1) | 2009[ |
| Pungiolide B (233) | Asteraceae | Xanthium brasilicum | 6.53 (K1) | 2009[ |
| Diguaiaperfolin (234) | Asteraceae | Eupatorium perfoliatum | 2.0 | 2011[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Trichloranoid A (235) | Chloranthaceae | Chloranthus spicatus | 2.50~5.00 (Dd2) | 2021[ |
| Trichloranoid D (236) | Chloranthaceae | Chloranthus spicatus | 10.00~15.00 (Dd2) | 2021[ |
| Trishizukaol A (237) | Chloranthaceae | Chloranthus spicatus | 1.25~2.50 (Dd2) | 2021[ |
| Compd. | Family | Plant | IC50/(μmol•L－1) | Year |
|---|---|---|---|---|
| Trichloranoid A (235) | Chloranthaceae | Chloranthus spicatus | 2.50~5.00 (Dd2) | 2021[ |
| Trichloranoid D (236) | Chloranthaceae | Chloranthus spicatus | 10.00~15.00 (Dd2) | 2021[ |
| Trishizukaol A (237) | Chloranthaceae | Chloranthus spicatus | 1.25~2.50 (Dd2) | 2021[ |
| [1] |
Winter, R. W.; Kelly, J. X.; Smilkstein, M. J.; Dodean, R.; Bagby, G. C.; Rathbun, R. K.; Levin, J. I.; Hinrichs, D.; Riscoe, M. K. Exp. Parasitol. 2006, 114, 47.
pmid: 16828746 |
| [2] |
Saxena, S.; Pant, N.; Jain, D. C.; Bhakuni, R. S. Curr. Sci. India 2003, 85, 1314.
|
| [3] |
Batista, R.; de Jesus Silva Júnior, A.; de Oliveira, A. B. Molecules 2009, 14, 3037.
doi: 10.3390/molecules14083037 pmid: 19701144 |
| [4] |
Bero, J.; Frédérich, M.; Quetin-Leclercq, J. J. Pharm. Pharmacol. 2009, 61, 1401.
doi: 10.1211/jpp.61.11.0001 |
| [5] |
Bero, J.; Quetin-Leclercq, J. Planta Med. 2011, 77, 631.
doi: 10.1055/s-0030-1250405 |
| [6] |
Kaur, K.; Jain, M.; Kaur, T.; Jain, R. Bioorg. Med. Chem. 2009, 17, 3229.
doi: 10.1016/j.bmc.2009.02.050 |
| [7] |
Nogueira, C.; Lopes, L. Molecules 2011, 16, 2146.
doi: 10.3390/molecules16032146 |
| [8] |
Zhang, J.-P.; Wang, G.-W.; Tian, X.-H.; Yang, Y.-X.; Liu, Q.-X.; Chen, L.-P.; Li, H.-L.; Zhang, W.-D. J. Ethnopharmacol. 2015, 163, 173.
doi: 10.1016/j.jep.2015.01.027 |
| [9] |
Zhang, L.; Duan, J.; Lv, J. J. Chin. Pharm. Sci. 2017, 26, 317.
|
| [10] |
Karioti, A.; Skaltsa, H.; Zhang, X.; Tonge, P. J.; Perozzo, R.; Kaiser, M.; Franzblau, S. G.; Tasdemir, D. Phytomedicine 2008, 15, 1125.
doi: 10.1016/j.phymed.2008.02.018 |
| [11] |
Du, Y.; Pearce, K. C.; Dai, Y.; Krai, P.; Dalal, S.; Cassera, M. B.; Goetz, M.; Crawford, T. D.; Kingston, D. G. I. J. Nat. Prod. 2017, 80, 1639.
doi: 10.1021/acs.jnatprod.7b00247 |
| [12] |
Ganfon, H.; Bero, J.; Tchinda, A. T.; Gbaguidi, F.; Gbenou, J.; Moudachirou, M.; Frederich, M.; Quetin-Leclercq, J. J. Ethno- pharmacol. 2012, 141, 411.
|
| [13] |
Jansen, O.; Tits, M.; Angenot, L.; Nicolas, J.-P.; De Mol, P.; Nikiema, J.-B.; Frederich, M. Malaria J. 2012, 11, 289.
doi: 10.1186/1475-2875-11-289 |
| [14] |
Francois, G.; Passreiter, C. M.; Woerdenbag, H. J.; VanLooveren, M. Planta Med. 1996, 62, 126.
doi: 10.1055/s-2006-957833 |
| [15] |
Oketch-Rabah, H. A.; Christensen, S. B.; Frydenvang, K.; Dossaji, S. F.; Theander, T. G.; Cornett, C.; Watkins, W. M.; Kharazmi, A.; Lemmich, E. Planta Med. 1998, 64, 559.
pmid: 9741304 |
| [16] |
Moon, H.-I. Parasitol. Res. 2007, 100, 1147.
doi: 10.1007/s00436-006-0369-7 |
| [17] |
Chung, I.-M.; Kim, M.-Y.; Moon, H.-I. Parasitol. Res. 2008, 103, 341.
doi: 10.1007/s00436-008-0977-5 |
| [18] |
Mokoka, T. A.; Xolani, P. K.; Zimmermann, S.; Hata, Y.; Adams, M.; Kaiser, M.; Moodley, N.; Maharaj, V.; Koorbanally, N. A.; Hamburger, M.; Brun, R.; Fouche, G. Planta Med. 2013, 79, 1380.
doi: 10.1055/s-00000058 |
| [19] |
Pillay, P.; Vleggaar, R.; Maharaj, V. J.; Smith, P. J.; Lategan, C. A.; Chouteau, F.; Chibale, K. Phytochemistry 2007, 68, 1200.
doi: 10.1016/j.phytochem.2007.02.019 |
| [20] |
Chea, A.; Hout, S.; Long, C.; Marcourt, L.; Faure, R.; Azas, N.; Elias, R. Chem. Pharm. Bull. 2006, 54, 1437.
doi: 10.1248/cpb.54.1437 |
| [21] |
Liu, Y. x.; Rakotondraibea, L. H.; Brodie, P. J.; Wiley, J. D.; Cassera, M. B.; Goetzc, M.; Kingstona, D. G. I. Nat. Prod. Commun. 2014, 9, 1403.
|
| [22] |
Vongvanich, N.; Kittakoop, P.; Charoenchai, P.; Intamas, S.; Sriklung, K.; Thebtaranonth, Y. Planta Med. 2006, 72, 1427.
pmid: 17089326 |
| [23] |
Chukwujekwu, J. C.; Lategan, C. A.; Smith, P. J.; Heerden, F. R. V.; Staden, J. V. S. Afr. J. Bot. 2009, 75, 176.
doi: 10.1016/j.sajb.2008.10.001 |
| [24] |
Magadula, J. J.; Erasto, P. Nat. Prod. Rep. 2009, 26, 1535.
doi: 10.1039/b906089h pmid: 19936385 |
| [25] |
Mehrotra, E.; Vishwakarma, J.; Tripathi, A. C.; Sonar, P. K.; Saraf, S. K. Nat. Prod. Res. 2017, 33, 568.
doi: 10.1080/14786419.2017.1396595 |
| [26] |
Graziose, R.; Rathinasabapathy, T.; Lategan, C.; Poulev, A.; Smith, P. J.; Grace, M.; Lila, M. A.; Raskin, I. J. Ethnopharmacol. 2011, 133, 26.
doi: 10.1016/j.jep.2010.08.059 pmid: 20826204 |
| [27] |
Ortet, R.; Prado, S.; Mouray, E.; Thomas, O. P. Phytochemistry 2008, 69, 2961.
doi: 10.1016/j.phytochem.2008.09.022 |
| [28] |
Goffin, E.; da Cunha, A. P.; Ziemons, E.; Tits, M.; Angenot, L.; Frederich, M. Phytochem. Anal. 2003, 14, 378.
doi: 10.1002/(ISSN)1099-1565 |
| [29] |
Goffin, E.; Ziemons, E.; De Mol, P.; de Madureira Mdo, C.; Martins, A. P.; da Cunha, A. P.; Philippe, G.; Tits, M.; Angenot, L.; Frederich, M. Planta Med. 2002, 68, 543.
pmid: 12094301 |
| [30] |
Ngarivhume, T.; Noreljaleel, A.; Bonnet, S.; Wilhelm, A. Chemistry 2021, 3, 854.
doi: 10.3390/chemistry3030062 |
| [31] |
Toyang, N. J.; Krause, M. A.; Fairhurst, R. M.; Tane, P.; Bryant, J.; Verpoorte, R. J. Ethnopharmacol. 2013, 147, 618.
doi: 10.1016/j.jep.2013.03.051 pmid: 23542146 |
| [32] |
Pedersen, M. M.; Chukwujekwu, J. C.; Lategan, C. A.; van Staden, J.; Smith, P. J.; Staerk, D. Phytochemistry 2009, 70, 601.
doi: 10.1016/j.phytochem.2009.02.005 pmid: 19298984 |
| [33] |
Rucker, G.; Walter, R. D.; Manns, D.; Mayer, R. Planta Med. 1991, 57, 295.
doi: 10.1055/s-2006-960099 |
| [34] |
Kim, J.-J.; Chung, I.-M.; Jung, J.-C.; Kim, M.-Y.; Moon, H.-I. J. Enzym. Inhib. Med. Chem. 2009, 24, 247.
doi: 10.1080/14756360802051610 |
| [35] |
Chung, I.-M.; Moon, H.-I. J. Enzym. Inhib. Med. Chem. 2009, 24, 131.
doi: 10.1080/14756360801936274 |
| [36] |
Pillay, P.; Vleggaar, R.; Maharaj, V. J.; Smith, P. J.; Lategan, C. A. J. Ethnopharmacol. 2007, 112, 71.
doi: 10.1016/j.jep.2007.02.002 |
| [37] |
Greve, H. L.; Kaiser, M.; Schmidt, T. J. Planta Med. 2020, 86, 643.
doi: 10.1055/a-1157-9463 |
| [38] |
Tchuendem, M. H. K.; Mbah, J. A.; Tsopmo, A.; Ayafor, J. F.; Sterner, O.; Okunjic, C. C.; Iwu, M. M.; Schuster, B. M. Phytochemistry 1999, 52, 1095.
pmid: 10643672 |
| [39] |
Sirignano, C.; Hammami, S.; El Mokni, R.; Blagborough, A.; Luciano, P.; Rigano, D.; Scafati, O. Phytochemistry 2021, 183, 112632.
doi: 10.1016/j.phytochem.2020.112632 pmid: 33360528 |
| [40] |
Rucker, G.; Schenkel, E. P.; Manns, D.; Mayer, R.; Heiden, K.; Heinzmann, B. M. Planta Med. 1996, 62, 565.
doi: 10.1055/s-2006-957974 |
| [41] |
Szpilman, A.; Korshin, E.; Rozenberg, H.; Bachi, M. J. Org. Chem. 2005, 70, 3618.
pmid: 15844999 |
| [42] |
Moradi-Afrapoli, F.; Ebrahimi, S. N.; Smiesko, M.; Raith, M.; Zimmermann, S.; Nadjafi, F.; Brun, R.; Hamburger, M. Phyto- chemistry 2013, 85, 143.
|
| [43] |
Cubukcu, B.; Bray, D. H.; Warhurst, D. C.; Mericli, A. H.; Ozhatay, N.; Sariyar, G. Phytother. Res. 1990, 4, 203.
doi: 10.1002/(ISSN)1099-1573 |
| [44] |
Topcu, G.; Aydogmus, Z.; Imre, S.; Goren, A. C.; Pezzuto, J. M.; Clement, J. A.; Kingston, D. G. I. J. Nat. Prod. 2003, 66, 1505.
doi: 10.1021/np030176p |
| [45] |
Konig, G. M.; Wright, A. D.; Sticher, O.; Angerhofer, C. K.; Pezzuto, J. M. Planta Med. 1994, 60, 532.
doi: 10.1055/s-2006-959565 |
| [46] |
Sriphana, U.; Pitchuanchom, S.; Kongsaeree, P.; Yenjai, C. ScienceAsia 2013, 39, 95.
doi: 10.2306/scienceasia1513-1874.2013.39.095 |
| [47] |
Traore, M.; Zhai, L.; Chen, M.; Olsen, C. E.; Odile, N.; Pierre, G. I.; Bosco, O. J.; Robert, G. T.; Christensen, S. B. Nat. Prod. Res. 2007, 21, 13.
doi: 10.1080/14786410600921698 |
| [48] |
Kraft, C.; Jenett-Siems, K.; Siems, K.; Jakupovic, J.; Mavi, S.; Bienzle, U.; Eich, E. Phytother. Res. 2003, 17, 123.
|
| [49] |
Henchiri, H.; Bodo, B.; Deville, A.; Dubost, L.; Zourgui, L.; Raies, A.; Grellier, P.; Mambu, L. Phytochemistry 2009, 70, 1435.
doi: 10.1016/j.phytochem.2009.08.012 pmid: 19766274 |
| [50] |
Rukunga, G. M.; Muregi, F. W.; Omar, S. A.; Gathirwa, J. W.; Muthaura, C. N.; Peter, M. G.; Heydenreich, M.; Mungai, G. M. Fitoterapia 2008, 79, 188.
doi: 10.1016/j.fitote.2007.11.010 pmid: 18234452 |
| [51] |
Villaescusa-Castillo, L.; Diaz-Lanza, A. M.; Gasquet, M.; Delmas, F.; Ollivier, E.; Bernabe, M.; Faure, R.; Elias, R.; Balansard, G. Pharm. Biol. 2000, 38, 176.
doi: 10.1076/1388-0209(200007)3831-SFT176 pmid: 21214458 |
| [52] |
Chung, I.-M.; Seo, S.-H.; Kang, E.-Y.; Park, w.-H.; Park, S.-D.; Moon, H.-I. Phytother. Res. 2010, 24, 451.
doi: 10.1002/ptr.v24:3 |
| [53] |
Wu, X. R.; Shen, Y.; Cui, S. J.; Luo, X. L.; Xiao, C. J.; Jiang, B. Natur. Prod. Bioprosp. 2020, 10, 101.
|
| [54] |
Shen, Y.; Cui, S.-J.; Chen, H.; Shen, L.; Wang, M.; Dong, X.; Xiao, C.-J.; Jiang, B. J. Nat. Prod. 2020, 83, 927.
doi: 10.1021/acs.jnatprod.9b00761 pmid: 32233487 |
| [55] |
Wu, X.-R.; Shen, Y.; Diao, H.-M.; Dong, X.; Xiao, C.-J.; Jiang, B. Phytochemistry 2022, 193, 112999.
doi: 10.1016/j.phytochem.2021.112999 |
| [56] |
Lategan, C. A.; Campbell, W. E.; Seaman, T.; Smith, P. J. J. Ethnopharmacol. 2009, 121, 92.
doi: 10.1016/j.jep.2008.10.007 pmid: 18996179 |
| [57] |
That, Q. T.; Jossang, J.; Jossang, A.; Phi Phung Nguyen, K.; Ginette, J. J. Org. Chem. 2007, 72, 7102.
doi: 10.1021/jo070771m |
| [58] |
Sangsopha, W.; Lekphrom, R.; Kanokmedhakul, S.; Kanok- medhakul, K. Phytochem. Lett. 2016, 17, 278.
doi: 10.1016/j.phytol.2016.08.001 |
| [59] |
Becker, J. V. W.; van der Merwe, M. M.; van Brummelen, A. C.; Pillay, P.; Crampton, B. G.; Mmutlane, E. M.; Parkinson, C.; van Heerden, F. R.; Crouch, N. R.; Smith, P. J.; Mancama, D. T.; Maharaj, V. J. Malaria J. 2011, 10, 295.
doi: 10.1186/1475-2875-10-295 |
| [60] |
Duc, T. P.; Thien, T. V. N.; Jossang, A.; Kim, P. P. N.; Grellier, P.; Jaureguiberry, G.; That, Q. T. Phytochem. Lett. 2016, 17, 304.
doi: 10.1016/j.phytol.2016.06.001 |
| [61] |
Mba'ning, B. M.; Lenta, B. N.; Noungoué, D. T.; Antheaume, C.; Fongang, Y. F.; Ngouela, S. A.; Boyom, F. F.; Rosenthal, P. J.; Tsamo, E.; Sewald, N.; Laatsch, H. Phytochemistry 2013, 96, 347.
doi: 10.1016/j.phytochem.2013.06.022 pmid: 23863332 |
| [62] |
Acebey, L.; Jullian, V.; Sereno, D.; Chevalley, S.; Estevez, Y.; Moulis, C.; Beck, S.; Valentin, A.; Gimenez, A.; Sauvain, M. Planta Med. 2010, 76, 365.
doi: 10.1055/s-0029-1186192 pmid: 19830657 |
| [63] |
Claudino, V. D.; da Silva, K. C.; Cechinel Filho, V.; Yunes, R. A.; Delle Monache, F.; Gimenez, A.; Salamanca, E.; Gutierrez-Yapu, D.; Malheiros, A. Mem. I. Oswaldo. Cruz. 2013, 108, 140.
doi: S0074-02762013000200140 pmid: 23579790 |
| [64] |
Nyaba, Z. N.; Murambiwa, P.; Opoku, A. R.; Mukaratirwa, S.; Shode, F. O.; Simelane, M. B. C. Malaria J. 2018, 17, 296.
doi: 10.1186/s12936-018-2439-6 |
| [65] |
Grace, M. H.; Lategan, C.; Mbeunkui, F.; Graziose, R.; Smith, P. J.; Raskin, I.; Lila, M. A. Nat. Prod. Commun. 2010, 5, 1869.
pmid: 21299109 |
| [66] |
Zhang, T.-J.; Wang, Y.-F.; Liu, D.; Li, L.-G.; Guo, R.-X.; Shi, Q.-W.; Dong, Y.-P. Chin. Tradit. Herb. Drugs 2016, 47, 3351. (in Chinese)
|
|
( 张铁军, 王于方, 刘丹, 李力更, 郭瑞霞, 史清文, 董燕平, 中草药, 2016, 47, 3351.)
|
|
| [67] |
Klayman, D. L.; Lin, A. J.; Acton, N.; Scovill, J. P.; Hoch, J. M.; Milhous, W. K.; Theoharides, A. D. J. Nat. Prod. 1984, 47, 715.
doi: 10.1021/np50034a027 pmid: 6387056 |
| [68] |
Thebtaranonth, C.; Thebtaranonth, Y.; Wanauppathamkul, S.; Yuthavong, Y. Phytochemistry 1995, 40, 125.
pmid: 7546546 |
| [69] |
Takaya, Y.; Kurumada, K.; Takeuji, Y.; Kim, H. S.; Shibata, Y.; Ikemoto, N.; Wataya, Y.; Oshima, Y. Tetrahedron Lett. 1998, 39, 1361.
doi: 10.1016/S0040-4039(97)10844-9 |
| [70] |
Hooper, M.; Kirby, G. C.; Kulkarni, M. M.; Kulkarni, S. N.; Nagasampagi, B. A.; O'Neill, M. J.; Phillipson, J. D.; Rojatkar, S. R.; Warhurst, D. C. Eur. J. Med. Chem. 1990, 25, 717.
doi: 10.1016/0223-5234(90)90190-E |
| [71] |
Ramanandraibe, V.; Martin, M. T.; Rakotondramanana, D. L.; Mambu, L.; Ramanitrahasimbola, D.; Labaied, M.; Grellier, P.; Rasoanaivo, P.; Frappier, F. J. Nat. Prod. 2005, 68, 800.
pmid: 15921436 |
| [72] |
Francois, G.; Passreiter, C. M. Phytother. Res. 2004, 18, 184.
doi: 10.1002/ptr.1376 |
| [73] |
Yu, H. W.; Wright, C. W.; Cai, Y.; Yang, S. L.; Phillipson, J. D.; Kirby, G. C.; Warhurst, D. C. Phytother. Res. 1994, 8, 436.
doi: 10.1002/(ISSN)1099-1573 |
| [74] |
Pan, E.; Gorka, A. P.; Alumasa, J. N.; Slebodnick, C.; Harinan- tenaina, L.; Brodie, P. J.; Roepe, P. D.; Randrianaivo, R.; Birkinshaw, C.; Kingston, D. G. I. J. Nat. Prod. 2011, 74, 2174.
doi: 10.1021/np200499d |
| [75] |
Nour, A. M. M.; Khalid, S. A.; Kaiser, M.; Brun, R.; Abdallah, W. E.; Schmidt, T. J. Planta Med. 2009, 75, 1363.
doi: 10.1055/s-0029-1185676 |
| [76] |
Sahoo, R. K.; Tamuli, K. J.; Lhouvum, N.; Dutta, D.; Bordoloi, M.; Sharma, H. K.; Gogoi, K.; Bhattacharyya, D. R. S. Afr. J. Bot. 2020, 135, 35.
doi: 10.1016/j.sajb.2020.08.006 |
| [77] |
Takaya, Y.; Takeuji, Y.; Akasaka, M.; Nakagawasai, O.; Tadano, T.; Kisara, K.; Kim, H. S.; Wataya, Y.; Niwa, M.; Oshima, Y. Tetrahedron 2000, 56, 7673.
doi: 10.1016/S0040-4020(00)00682-7 |
| [78] |
Kamaraj, C.; Rahuman, A. A.; Roopan, S. M.; Bagavan, A.; Elango, G.; Zahir, A. A.; Rajakumar, G.; Jayaseelan, C.; Santhoshkumar, T.; Marimuthu, S.; Kirthi, A. V. Parasitol. Res. 2014, 113, 1657.
doi: 10.1007/s00436-014-3810-3 |
| [79] |
Kanokmedhakul, S.; Kanokmedhakul, K.; Lekphrom, R. J. Nat. Prod. 2007, 70, 1536.
pmid: 17845001 |
| [80] |
Zhang, H. J.; Tamez, P. A.; Aydogmus, Z.; Tan, G. T.; Saikawa, Y.; Hashimoto, K.; Nakata, M.; Van Hung, N.; Xuan, L. T.; Cuong, N. M.; Soejarto, D. D.; Pezzuto, J. M.; Fong, H. H. S. Planta Med. 2002, 68, 1088.
doi: 10.1055/s-2002-36350 |
| [81] |
Karioti, A.; Skaltsa, H.; Linden, A.; Perozzo, R.; Brun, R.; Tasdemir, D. J. Org. Chem. 2007, 72, 8103.
doi: 10.1021/jo701751w |
| [82] |
Efange, S. M. N.; Brun, R.; Wittlin, S.; Connolly, J. D.; Hoye, T. R.; McAkam, T.; Makolo, F. L.; Mbah, J. A.; Nelson, D. P.; Nyongbela, K. D.; Wirmum, C. K. J. Nat. Prod. 2009, 72, 280.
doi: 10.1021/np800338p pmid: 19199815 |
| [83] |
David, J. P.; Santos, A. J. d. O.; Guedes, M. L. d. S.; David, J. M.; Chai, H.-B.; Pezzuto, J. M.; Angerhofer, C. K.; Cordell, G. A. Pharm. Biol. 1999, 37.
|
| [84] |
Shen, Y.; Chen, H.; Shen, L.; Li, H.-X.; Dong, X.; Xiao, C.-J.; Jiang, B. Bioorg. Chem. 2020, 95, 103488.
doi: 10.1016/j.bioorg.2019.103488 |
| [85] |
Zhou, B.; Wu, Y.; Dalal, S.; Merino, E. F.; Liu, Q.-F.; Xu, C.-H.; Yuan, T.; Ding, J.; Kingston, D. G. I.; Cassera, M. B.; Yue, J.-M. J. Nat. Prod. 2017, 80, 96.
doi: 10.1021/acs.jnatprod.6b00744 pmid: 27997206 |
| [86] |
Butler, J. H.; Baptista, R. P.; Valenciano, A. L.; Zhou, B.; Kissinger, J. C.; Tumwebaze, P. K.; Rosenthal, P. J.; Cooper, R. A.; Yue, J.-M.; Cassera, M. B. ACS Infect. Dis. 2020, 6, 2994.
doi: 10.1021/acsinfecdis.0c00487 |
| [87] |
Zhou, B.; Zimbres, F. M.; Butler, J. H.; Xu, C. H.; Haney, R. S.; Wu, Y.; Cassera, M. B.; Yue, J. M. Sci. China Chem. 2022, 65, 82.
doi: 10.1007/s11426-021-1124-x |
| [88] |
Zhou, B.; Liu, Q.-F.; Dalal, S.; Cassera, M. B.; Yue, J.-M. Org. Lett. 2017, 19, 734.
doi: 10.1021/acs.orglett.7b00066 pmid: 28124917 |
| [89] |
Maas, M.; Hensel, A.; Costa, F. B. d.; Brun, R.; Kaiser, M.; Schmidt, T. J. Phytochemistry 2011, 72, 635.
doi: 10.1016/j.phytochem.2011.01.025 |
| [90] |
Zhou, J.-S.; Liu, Q.-F.; Zimbres, F. M.; Butler, J. H.; Cassera, M. B.; Zhou, B.; Yue, J.-M. Org. Chem. Front. 2021, 8, 1795.
doi: 10.1039/D1QO00089F |
| [91] |
Fidock, D. A.; Rosenthal, P. J.; Croft, S. L.; Brun, R.; Nwaka, S. Nat. Rev. Drug. Discov. 2004, 3, 509.
doi: 10.1038/nrd1416 pmid: 15173840 |
| [92] |
Zhou, B.; Yue, J.-M. Natl. Sci. Rev. 2022, 9, nwac112.
doi: 10.1093/nsr/nwac112 |
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| [10] | Li Xiaojun, Zhang Wanbin, Gao Shuanhu. Total Synthesis of Complex Natural Products: Combination of Chemical Synthesis and Biosynthesis Strategies [J]. Chin. J. Org. Chem., 2018, 38(9): 2185-2198. |
| [11] | Jin Wenbing, Yuan Hua, Tang Gongli. Strategies for Construction of Cyclopropanes in Natural Products [J]. Chin. J. Org. Chem., 2018, 38(9): 2324-2334. |
| [12] | Cheng Lei, Liu Guiyuan, Pan Yinchi, Zhang Maosheng, Xiao Shiji. Two New Sesquterpenoids from Fructus Carotae [J]. Chin. J. Org. Chem., 2018, 38(7): 1829-1832. |
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| [14] | Chen Yang, Li Wei-Dong Z. Asymmetric Total Synthesis of (－)-Cephalotaxine [J]. Chin. J. Org. Chem., 2017, 37(8): 1885-1902. |
| [15] | Xiao Chunxia, Cao Lin, Wang Jia, Miao Yinlong, Fan Huafang. Advances in the Collective Synthesis of Lycopodium Alkaloids [J]. Chin. J. Org. Chem., 2017, 37(4): 810-823. |
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