Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (03): 409-422.DOI: 10.6023/cjoc201211003 Previous Articles     Next Articles

ACCOUNT

重新挖掘和调查糠卤酸: 最近的发展和在药物研发中的应用

张霁, 张英俊   

  1. 广东东阳光药业药物研究院 东莞 523871
  • 收稿日期:2012-11-02 修回日期:2012-11-27 发布日期:2012-12-03
  • 通讯作者: 张霁 E-mail:zhangji@hecpharm.com; jizhang009@yahoo.com

Reinvestigation of Mucohalic Acids: Recent Development and Application in Drug Discovery

Zhang Ji, Zhang Yingjun   

  1. HEC Pharm Group, HEC R&D Center, Dongguan 523871
  • Received:2012-11-02 Revised:2012-11-27 Published:2012-12-03

The recent synthetic development and applications of mucochloric acid, mucobromic acid and their derivatives are described, mainly focus on our work using these multiple functional molecules to access a wide variety of γ-butenolides, γ-lactams, 4,5-dihalopyridazin-3-ones and other novel, multi-functionalized building blocks and pharmaceutical products.

Key words: mucohalic acid, mucochloric acid, mucobromic acid, butenolides, γ-lactams, 4,5-dihalopyridazin-3-ones