Synthesis and Anti-free Radical Activities of Several Novel Derivatives of Dehydroabietylamine

doi:10.6023/cjoc201211020

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (03): 562-567.DOI: 10.6023/cjoc201211020 Previous Articles Next Articles

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新型脱氢枞胺衍生物的合成及其抗自由基活性

陆洲, 刘超祥, 余星, 林中祥

南京林业大学化学工程学院南京 210037

收稿日期:2012-11-09 修回日期:2012-12-06 发布日期:2012-12-10
通讯作者: 林中祥 E-mail:linzhongxiang36@gmail.com
基金资助:
国家自然科学基金(No. 31170536)和江苏高校优势学科建设工程资助项目.

Synthesis and Anti-free Radical Activities of Several Novel Derivatives of Dehydroabietylamine

Lu Zhou, Liu Chaoxiang, Yu Xing, Lin Zhongxiang

College of Chemical Engineering Nanjing Forestry University, Nanjing 210037

Received:2012-11-09 Revised:2012-12-06 Published:2012-12-10
Supported by:
Project supported by the National Natural Science Foundation of China (No. 31170536) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

A series of novel derivatives of dehydroabietylamine were synthesized by introducing some groups with good free radical scavenging activities into the dehydroabietylamine, such as hydrazone, gallic acid, oxime and isoniazid. Structures of the synthesized compounds were characterized by IR, ¹H NMR, ¹³C NMR, MS and HRMS techniques. All the compounds were tested the ability on scavenging superoxide anion radical (O²^-) and 1,1-dipheny-2-picrylhydrazyl (DPPH·). The results indicate that the inhibitory rate of O²^- by (6) (38.18%) is twice as much as that of Vc (18.35%), and its capacity on scavenging DPPH· (IC₅₀＝0.002×10³ mg/L) is much better than Vc (IC₅₀＝0.236×10³ mg/L.

Key words: dehydroabietylamine, anti-free radical, acylhydrazone, gallic acid

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Lu Zhou, Liu Chaoxiang, Yu Xing, Lin Zhongxiang. Synthesis and Anti-free Radical Activities of Several Novel Derivatives of Dehydroabietylamine[J]. Chin. J. Org. Chem., 2013, 33(03): 562-567.

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新型脱氢枞胺衍生物的合成及其抗自由基活性

Synthesis and Anti-free Radical Activities of Several Novel Derivatives of Dehydroabietylamine

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