Chemical Constituents from the Branches and Leaves of Pyrus pashia Buch.-Ham.ex D.Don

doi:10.6023/cjoc201303041

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (06): 1284-1290.DOI: 10.6023/cjoc201303041 Previous Articles Next Articles

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棠梨枝叶的化学成分研究

赵冕^a, 蔡乐^a, 何健民^a,b, 尹田鹏^a, 隋迎春^a, 罗梦婷^a, 丁中涛^a

a 教育部自然资源药物化学重点实验室云南大学化学科学与工程学院昆明 650091;
b 保山学院资源环境学院保山 678000

收稿日期:2013-03-26 修回日期:2013-04-25 发布日期:2013-05-06
通讯作者: 丁中涛 E-mail:ztding@ynu.edu.cn
基金资助:
国家自然科学基金(No.21002084)和云南省自然科学基金(No.2010CD017)资助项目.

Chemical Constituents from the Branches and Leaves of Pyrus pashia Buch.-Ham.ex D.Don

Zhao Mian^a, Cai Le^a, He Jianmin^a,b, Yin Tianpeng^a, Sui Yingchun^a, Luo Mengting^a, Ding Zhongtao^a

a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091;
b College of Resource and Environment, Baoshan University, Baoshan 678000

Received:2013-03-26 Revised:2013-04-25 Published:2013-05-06
Supported by:
Project supported by the National Natural Science Foundation of China (No.21002084), and the Natural Science Foundation of China of Yunnan Province (No.2010CD017).

1. Chemical Constituents from the Branches and Leaves of Pyrus pashia Buch.-Ham.ex D.Don.PDF(1883KB)

Abstract

Seventeen compounds were isolated from the branches and leaves of Pyrus pashia Buch.-Ham.ex D.Don.On the basis of spectroscopic methods (HR-ESIMS, 1D- and 2D-NMR), their structures were identified as pashinin A (1), gastrodin-7-O-cis-caffeoyl ester (2), gastrodin-7-O-trans-caffeoyl ester (3), kaempferol-3-β-D-(6-O-trans-p-coumaroyl)glu- copyranoside (4), kaempferol-3-β-D-(6-O-cis-p-coumaroyl)glucopyranoside (5), gastrodin-7-O-p-hydroxybenzoyl ester (6), arbutin (7), robustaside B (8), tormentic acid (9), euscaphic acid (10), quercetin-3-O-β-D-glucopyranoside (11), 2R,3R-dihydyoquercetin (12), luteolin-4'-O-β-D-glucopyranoside (13), apigenin-4'-O-β-D-glucopyranoside (14), 5,7,4'-trihy- droxyisoflavone-7-O-β-D-glucopyranoside (15), genistein (16), caffeic acid (17).Among them, 1 and 2 were new compounds, 3 was a new natural product, 4～16 were isolated from this plant for the first time.Compounds 1～3 showed no cytotoxic effects on tumor cell (IC₅₀ >40 μmol·L^-1).1 and 4 exhibited weak anti-HIV-1 activities.

Key words: Pyrus pashia, branches and leaves, pashinin A, gastrodin-7-O-cis-caffeoyl ester, anti-HIV-1 activities

Cite this article

Zhao Mian, Cai Le, He Jianmin, Yin Tianpeng, Sui Yingchun, Luo Mengting, Ding Zhongtao. Chemical Constituents from the Branches and Leaves of Pyrus pashia Buch.-Ham.ex D.Don[J]. Chin. J. Org. Chem., 2013, 33(06): 1284-1290.

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[1] Yu, D.Q.Flora Reipublicae Popularis Sinicae, Vol.36, Science Press, Beijing, 1986, p.384 (in Chinese).(俞德浚, 中国植物志, 第36卷, 科学出版社, 北京, 1986, p.384.)
[2] Bhakuni, D.S.; Gupta, N.C.; Satish, S.; Sharma, S.C.; Shukla, Y.N.; Tandon, J.S.Phytochemistry 1971, 10, 2247.
[3] Bhakuni, D.S.; Satish, S.; Shukla, Y.N.; Tandon, J.S.Phytochemistry 1971, 10, 2829.
[4] Liu, C.S.; Tai, Z.G.; Liu, Y.; Ma, Y.C.; Cai, L.; Ding, Z.T.Lishizhen Med. Mater. Med. Res.2011, 22, 2373 (in Chinese).(刘传水, 太志刚, 刘阳, 马迎聪, 蔡乐, 丁中涛, 时珍国医国药, 2011, 22, 2373.)
[5] Dong, L.H.; Tai, Z.G.; Yang, Y.B.; Liu, C.S.; Cai, L.; Ding, Z.T.West China J. Pharm. Sci.2010, 25, 636 (in Chinese).(董刘宏, 太志刚, 杨亚滨, 刘传水, 蔡乐, 丁中涛, 华西药学杂志, 2010, 25, 636.)
[6] Xu, F.Q.; Wang, C.; Yang, L.P.; Luo, H.R.; Fan, W.W.; Zi, C.T.; Dong, F.W.; Hu, J.M.; Zhou, J.Food Chem.2013, 136, 94.
[7] Burns, D.C.; Ellis, D.A.; March, R.E.Magn.Reson.Chem.2007, 45, 835.
[8] Mei, W.L.; Gan, Y.J.; Que, D.M.; Li, X.N.; Dai, H.F.Chin.J.Org.Chem.2011, 31, 533 (in Chinese).(梅文莉, 干玉娟, 阙东枚, 李小娜, 戴好富, 有机化学, 2011, 31, 533.)
[9] Ovenden, S.P.B.; Cobbe, M.; Kissell, R.; Birrell, G.W.; Chavchich, M.; Edstein, M.D.J.Nat.Prod.2011, 74, 74.
[10] Cai, L.; Liu, C.S.; Fu, X.W.; Shen, X.J.; Yin, T.P.; Yang, Y.B.; Ding, Z.T.Nat.Prod.Bioprospect.2012, 2, 150.
[11] Hu, H, B.; Fan, J.Chin.Pharm.J.2009, 44, 1137 (in Chinese).(胡浩斌, 樊君, 中国药学杂志, 2009, 44, 1137.)
[12] Cai, L.; Chen, D.L.; Liu, S.Y.; Wang, F.P.Chem.Pharm.Bull.2006, 54, 779.
[13] Li, Y.; Wang, C.L.; Wang, F.F; Dong, H.L.; Guo, S.X.; Yang, J.S.; Xiao, P.G.China J.Chin.Mater.Med.2010, 35, 1715 (in Chinese).(李燕, 王春兰, 王芳菲, 董海玲, 郭顺星, 杨峻山, 肖培根, 中国中药杂志, 2010, 35, 1715.)
[14] Advanced Chemistry Development (ACD/Labs) Software V11.02 (® 1994-2013 ACD/Labs).
[15] Jung, M.; Park, M.Molecules 2007, 12, 2130.
[16] Tsukamoto, S.; Tomise, K.; Aburatani, M.; Onuki, H.; Hirorta, H.; Ishiharajima, E.; Ohta, T.J.Nat.Prod.2004, 67, 1839.
[17] Christian, Z.; Ernst, P.; Ellmerer, M.; Hermann, S.Phytochem.Anal.2001, 12, 281.
[18] Zhang, Y.; Guo, F.J.; Zeng, P.; Jia, Q.; Li, Y.M.; Zhu, W.L.; Chen, K.X.China J.Chin.Mater.Med.2012, 37, 1782 (in Chinese).(张勇, 郭夫江, 曾鹏, 贾琦, 李医明, 朱维良, 陈凯先, 中国中药杂志, 2012, 37, 1782.)
[19] Ahmed, A.S.; Nakamura, N.; Meselhy, M.S.; Makhboul, M.A.; El-Emary, N.; Hattori, M.Phytochemistry 2000, 53, 149.
[20] Numata, A.; Yang, P.; Takahashi, C.; Fujiki, R.; Nabae, M.; Fujita, E.Chem.Pharm.Bull.1989, 37, 648.
[21] Kajjout, M.; Rolando, C.Tetrahedron 2011, 67, 4731.
[22] Baderschneider, B.; Winterhalter, P.J.Agric.Food Chem.2001, 49, 2788.
[23] Wang, G.K.; Lin, B.B.; Liu, X.X.; Shen, Y.J.; Qin, M.J.Nat.Prod.Res.Dev.2012, 24, 336 (in Chinese).(王国凯, 林彬彬, 刘欣欣, 申亚军, 秦民坚, 天然产物研究及开发, 2012, 24, 336.)
[24] Lee, S.S.; Lin, Y.S.; Chen, C.K.J.Nat.Prod.2009, 72, 1249.
[25] Zhang, X.; Song, Q.S.Chin.Trad.Herb.Drugs 2009, 40, 865 (in Chinese).(张雪, 宋启示, 中草药, 2009, 40, 865.)
[26] [26] Wang, Q.; Luo, S.D.; Xu, Y.Y.Nat.Prod.Res.Dev.2012, 24, 285 (in Chinese).(汪琼, 罗士德, 徐永艳, 天然产物研究与开发, 2012, 24, 285).
[27] Peng, B.; He, C.N.; Xu, J.L.; Xiao, W.; Peng, Y.; Xiao, P.G.Chin.Trad.Herb.Drugs 2010, 41, 1950 (in Chinese).(彭冰, 何春年, 许利嘉, 肖伟, 彭勇, 肖培根, 中草药, 2010, 41, 1950.)

棠梨枝叶的化学成分研究

Chemical Constituents from the Branches and Leaves of Pyrus pashia Buch.-Ham.ex D.Don

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