Synthesis and Anti-tumor Activities of Resveratrol Derivatives on Cervical Cancer HeLa Cells

doi:10.6023/cjoc201303035

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (06): 1279-1283.DOI: 10.6023/cjoc201303035 Previous Articles Next Articles

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白藜芦醇衍生物的合成及抑制宫颈癌HeLa细胞肿瘤活性

杜成^a, 任玉杰^a,b, 王庆伟^a, 金鹭^a

a 上海应用技术学院化学与环境工程学院上海 201418;
b 中国科学院上海有机化学研究所天然产物有机合成化学重点实验室上海 200032

收稿日期:2013-03-23 修回日期:2013-04-26 发布日期:2013-05-06
通讯作者: 任玉杰 E-mail:clab@sit.edu.cn
基金资助:
上海市教委科研创新重点(No.12ZZ188);上海市科委(No.11430502500);上海高校特聘教授(东方学者)岗位计划(No.405ZK110060002)资助项目.

Synthesis and Anti-tumor Activities of Resveratrol Derivatives on Cervical Cancer HeLa Cells

Du Cheng^a, Ren Yujie^a,b, Wang Qingwei^a, Jin Lu^a

a School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418;
b Key Laboratory Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received:2013-03-23 Revised:2013-04-26 Published:2013-05-06
Supported by:
Project Supported by the Innovation Program of Shanghai Municipal Education Commission (No.12ZZ188), the Science and Technology Commission of Shanghai Municipal (No.11430502500), the Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (No.405ZK110060002).

Nine novel resveratrol derivatives were synthesized from resveratrol, chloroacetyl chloride, p-toluenesulfonyl chloride and p-methyl benzoyl chloride.These structures were confirmed by IR, ¹H NMR, ¹³C NMR and HR-MS techniques.The target compounds were evaluated for their anti-tumor activities against cervical cancer HeLa cells by 3-(4,5-dimethylthi- azol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method, and the results indicated that compounds 4a, 6a, 7b, 8b and 11c of all the derivatives displayed better activities than resveratrol against HeLa cells, the compounds 6a and 8b displayed excellent inhibition effect, with IC₅₀ values of 22.7 and 18.0 μmol/L, respectively, even higher than that of resveratrol (IC₅₀=114 μmol/L).The inhibitory ratio of compounds 6a and 8b were 95.5% and 87.7% against HeLa cells at the concentration of 150 μmol/L.

Key words: resveratrol, derivative, synthesis, HeLa cell, anti-tumor activities

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Du Cheng, Ren Yujie, Wang Qingwei, Jin Lu. Synthesis and Anti-tumor Activities of Resveratrol Derivatives on Cervical Cancer HeLa Cells[J]. Chin. J. Org. Chem., 2013, 33(06): 1279-1283.

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白藜芦醇衍生物的合成及抑制宫颈癌HeLa细胞肿瘤活性

Synthesis and Anti-tumor Activities of Resveratrol Derivatives on Cervical Cancer HeLa Cells

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