Steroids and Phenylpropanoids with Immunomodulatory Activities from the Stem Barks of Cinnamomum wilsonii

doi:10.6023/cjoc201303055

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (06): 1273-1278.DOI: 10.6023/cjoc201303055 Previous Articles Next Articles

Articles

川桂皮中具有免疫调节活性的甾体和苯丙素类化学成分

魏夏兰^a, 舒朋华^a, 刘婷婷^a, 向明^a, 张锦文^b, 薛永波^a, 罗增伟^a, 姚广民^a, 张勇慧^a

a 华中科技大学同济医学院药学院武汉 430030;
b 华中科技大学同济医学院附属同济医院武汉 430030

收稿日期:2013-03-31 修回日期:2013-04-28 发布日期:2013-05-31
通讯作者: 姚广民, 张勇慧 E-mail:gyap@hust.edu.cn;zhangyh@mails.tjmu.edu.cn
基金资助:
教育部留学回国人员科研启动基金(No.2010-1561, 第40批);教育部新世纪优秀人才计划(No.NCET-2008-0224)资助项目.

Steroids and Phenylpropanoids with Immunomodulatory Activities from the Stem Barks of Cinnamomum wilsonii

Wei Xialan^a, Shu Penghua^a, Liu Tingting^a, Xiang Ming^a, Zhang Jinwen^b, Xue Yongbo^a, Luo Zengwei^a, Yao Guangmin^a, Zhang Yonghui^a

a School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;
b Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030

Received:2013-03-31 Revised:2013-04-28 Published:2013-05-31
Supported by:
Project supported by the Scientific Research Foundation for the Returned Oversea Chinese Scholars, Ministry of Education (No.2010-1561, 40th) and the Program for New Century Excellent Talents in University, Ministry of Education (No.NCET-2008-0224).

1. Steroids and Phenylpropanoids with Immunomodulatory Activities from the Stem Barks of Cinnamomum wilsonii.PDF(284KB)

Abstract

A new steroid, (3S,22R,24R)-stigmast-5-ene-3β,22α-diol (1), together with ten known compounds, stigmast-5-ene-3β,7α,22α-triol (2), 24-ethylcholest-5-ene-3β,4β,22α-triol (3), stigmast-5-ene-3β,7α-diol (4), β-sitosterol (5), β-daucosterol (6), (1R,2R)-1-(4-hydroxy-3-methoxyphenyl)-1,2,3-propanetriol (7), (1S,2S)-1-(4-hydroxy-3-methoxyphenyl)- 1,2,3-propanetriol (8), eugenol (9), methoxyeugenol (10), and methyl (E)-ferulate (11) were isolated from the stem barks of Cinnamomum wilsonii.The structure including the absolute configuration of 1 was determined by spectroscopic data interpretation and X-ray single-crystal diffraction analysis with Cu Kα irradiation.Compounds 1～11 were evaluated for immunomodulatory activities against murine lymphocytes.1, 5 and 6 significantly inhibited the proliferation of murine ConA-induced T cells, and 6 and 9 significantly inhibited the proliferation of LPS-induced murine B cells.

Key words: Cinnamomum wilsonii, (3S,22R,24R)-stigmast-5-ene-3β,22α-diol, X-ray single-crystal diffraction, absolute con?guration, immunomodulatory activity

Cite this article

Wei Xialan, Shu Penghua, Liu Tingting, Xiang Ming, Zhang Jinwen, Xue Yongbo, Luo Zengwei, Yao Guangmin, Zhang Yonghui. Steroids and Phenylpropanoids with Immunomodulatory Activities from the Stem Barks of Cinnamomum wilsonii[J]. Chin. J. Org. Chem., 2013, 33(06): 1273-1278.

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川桂皮中具有免疫调节活性的甾体和苯丙素类化学成分

Steroids and Phenylpropanoids with Immunomodulatory Activities from the Stem Barks of Cinnamomum wilsonii

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