Synthesis of Nesiritide via Ligation of Peptide Hydrazide

doi:10.6023/cjoc201401039

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (7): 1452-1457.DOI: 10.6023/cjoc201401039 Previous Articles Next Articles

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多肽酰肼法合成Nesiritide

陈晨晨^a, 李思践^a, 陈轶群^b, 许华建^a, 李宜明^a

a 合肥工业大学化学工程学院医学工程学院合肥 230009;
b 安徽大学生命科学学院合肥 230009

收稿日期:2014-01-24 修回日期:2014-03-22 发布日期:2014-04-02
通讯作者: 许华建, 李宜明 E-mail:lym2007@mail.ustc.edu.cn
基金资助:
国家自然科学基金（Nos.21102083；21372058）资助项目.

Synthesis of Nesiritide via Ligation of Peptide Hydrazide

Chen Chenchen^a, Li Sijian^a, Chen Yiqun^b, Xu Huajian^a, Li Yiming^a

a School of Chemical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009;
b School of Life Science, Anhui University, Hefei 230601

Received:2014-01-24 Revised:2014-03-22 Published:2014-04-02
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 201102083, 21372058).

1. Synthesis of Nesiritide via Ligation of Peptide Hydrazide.PDF(371KB)

Abstract

Nesiritide is an important class of peptide vasodilator. It plays a significant role in the maintenance homeostasis of cardiovascular and kidney. Nowadays, nesiritide is mainly obtained by biological methods including gene recombinant expression, which is relative time-consuming. In present work, the chemical synthesis of nesiritide was reported by using (solid-phase peptide synthesis) (SPPS) strategy combining with the ligation of peptide hydrazides with high yield and purity. Therefore, it was considered that the method presented here provided a convinced alternative for acquiring pharmaceutical peptide in a large scale.

Key words: ligation of peptide hydrazide, native chemical ligation, peptide thioester, nesiritide

Cite this article

Chen Chenchen, Li Sijian, Chen Yiqun, Xu Huajian, Li Yiming. Synthesis of Nesiritide via Ligation of Peptide Hydrazide[J]. Chin. J. Org. Chem., 2014, 34(7): 1452-1457.

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多肽酰肼法合成Nesiritide

Synthesis of Nesiritide via Ligation of Peptide Hydrazide

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