Synthesis and Fungicidal Activity of 2,5-Disubstituted- 1,3,4-oxadiazole Derivatives

doi:10.6023/cjoc201403013

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (7): 1447-1451.DOI: 10.6023/cjoc201403013 Previous Articles Next Articles

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2,5-取代-1,3,4-噁二唑衍生物的合成与杀菌活性

刘建超, 王卫东, 贺红武

华中师范大学化学学院武汉 430079

收稿日期:2014-03-06 修回日期:2014-04-03 发布日期:2014-04-15
通讯作者: 贺红武 E-mail:he1208@mail.ccnu.edu.cn;liujc@mail.ccnu.edu.cn
基金资助:
国家重点基础研究发展规划（973计划，No.2010CB126100）、国家自然科学基金（Nos.21172090，31000867）和教育部创新团队项目部分（No.IRT0953）资助项目

Synthesis and Fungicidal Activity of 2,5-Disubstituted- 1,3,4-oxadiazole Derivatives

Liu Jianchao, Wang Weidong, He Hongwu

College of Chemistry, Central China Normal University, Wuhan 430079

Received:2014-03-06 Revised:2014-04-03 Published:2014-04-15
Supported by:
Project supported by the National Program on Key Basic Research Project (973 Program, No. 2010CB126100), the National Natural Science Foundation of China (Nos. 21172090, 31000867) and the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT0953).

A series of new 2,5-disubstituted-1,3,4-oxadiazole derivatives have been designed and synthesized by adding pyridine ring and thiazole ring to the structure of 1,3,4-oxadiazole. The structures of target compounds have been confirmed by ¹H NMR, EI-MS, IR spectroscopy and elemental analyses. The structure of 2-[(6-pyridin-3-yl)methylthio]-5-(pyridin-4-yl)- 1,3,4-oxadazole has been determined by single crystal X-ray diffraction. The results of preliminary bioassay indicated that some compounds possess potential fungicidal activities against Fusarium oxyporium, Gibberella zeae, Rhizoctonia solani, Dothiorella gregaria and Colletotrichum gossypii at a dosage of 5.0×10^-5 g/mL. The fungicidal activities of 1,3,4-oxadiazole derivatives adding thiazole ring were better than those of those adding pyridine ring.

Key words: 1,3,4-oxadiazole, pyridine ring, thiazole ring, fungicidal activity

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Liu Jianchao, Wang Weidong, He Hongwu. Synthesis and Fungicidal Activity of 2,5-Disubstituted- 1,3,4-oxadiazole Derivatives[J]. Chin. J. Org. Chem., 2014, 34(7): 1447-1451.

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2,5-取代-1,3,4-噁二唑衍生物的合成与杀菌活性

Synthesis and Fungicidal Activity of 2,5-Disubstituted- 1,3,4-oxadiazole Derivatives

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