Rencent Advances in Cyclin-Dependent Kinase Inhibitors with Purine Scaffold

doi:10.6023/cjoc201410039

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (5): 1022-1032.DOI: 10.6023/cjoc201410039 Previous Articles Next Articles

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具有嘌呤结构的细胞周期蛋白依赖性激酶抑制剂研究进展

张京玉^a, 王清龙^b, 侯学会^b, 刘宏民^c

a 河南中医学院药学院郑州 450018;
b 河南牧业经济学院质检系郑州 450011;
c 郑州大学药学院郑州 450001

收稿日期:2014-10-29 修回日期:2014-11-28 发布日期:2014-12-02
通讯作者: 侯学会, 刘宏民 E-mail:jyzhang2004@126.com;liuhmwork2014@126.com
基金资助:
河南省教育厅科学技术研究重点项目(No.14A150052),郑州市科技攻关计划(No.121PPTGG509-2)资助项目.

Rencent Advances in Cyclin-Dependent Kinase Inhibitors with Purine Scaffold

Zhang Jingyu^a, Wang Qinglong^b, Hou Xuehui^b, Liu Hongmin^c

a School of Pharmaceutical Science, Henan University of Taditional Chinese Medicine, Zhengzhou 450008;
b Department of Quality Detection and Management, Henan University of Animal Husbandry and Economy, Zhengzhou 450011;
c School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001

Received:2014-10-29 Revised:2014-11-28 Published:2014-12-02
Supported by:
Project supported by the Education Department of Henan Province Science and Technology Research Projects (No.14A150052), Scientific Research Plan of Zhenzhou (No.121PPTGG509-2).

Cell cycle is a basic characteristic of a cell that associates with its division and duplication. An entire cell cycle is regulated by a series of enzymes. The occurance of cell cycle disorder can lead to an excessive cell proliferation which may trigger cancer. However, the drugs that target cyclin-dependent kinases could spur the process of cancer cell apoptosis through interrupting the cell cycle. In this article, different kinds of cyclin-dependent kinases (CDKs), cyclins, the mechanism of cell cycle regulation and its relation with cancers are reviewed. The CDKs inhibitors with purine scaffold are introduced and their progresses in research and development are briefly discussed.

Key words: cell cycle, cyclin-dependent kinases, inhibitors, anticancer

Cite this article

Zhang Jingyu, Wang Qinglong, Hou Xuehui, Liu Hongmin. Rencent Advances in Cyclin-Dependent Kinase Inhibitors with Purine Scaffold[J]. Chin. J. Org. Chem., 2015, 35(5): 1022-1032.

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具有嘌呤结构的细胞周期蛋白依赖性激酶抑制剂研究进展

Rencent Advances in Cyclin-Dependent Kinase Inhibitors with Purine Scaffold

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