Progresses in the Total Synthesis and Structure Modification Studies of Lycorine

doi:10.6023/cjoc201409038

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (5): 1009-1021.DOI: 10.6023/cjoc201409038 Previous Articles Next Articles

REVIEW

石蒜碱的全合成及结构修饰研究进展

刘颖杰^a, 丁泽洋^c, 谭冲^a, 袁洪亮^b, 季宇彬^a,b

a 哈尔滨商业大学商业工程研究院哈尔滨 150076;
b 哈尔滨商业大学生命科学与环境科学研究中心哈尔滨 150076;
c 吉林大学化学学院长春 130000

收稿日期:2014-09-24 修回日期:2014-10-29 发布日期:2014-12-10
通讯作者: 季宇彬 E-mail:lyj850527@163.com
基金资助:
哈尔滨商业大学博士科研启动项目(No.14LG12)、哈尔滨商业大学青年教师自然科学基金(No.HCUL2013019)资助项目.

Progresses in the Total Synthesis and Structure Modification Studies of Lycorine

Liu Yingjie^a, Ding Zeyang^c, Tan Chong^a, Yuan Hongliang^b, Ji Yubin^a,b

a Business Engineering Research Institute, Harbin University of Commerce, Harbin 150076;
b Research Center on Life Science and Enviromental Science, Harbin University of Commerce, Harbin 150076;
c College of Chemistry, Jilin University, Changchun 130000

Received:2014-09-24 Revised:2014-10-29 Published:2014-12-10
Supported by:
Project supported by the Harbin University of Commerce Doctoral Research Project (No.14LG12) and the Natural Science Fund for Young Teachers of Harbin University of Commerce (No.HCUL2013019).

Lycorine is a very important class of isoquinoline alkaloids of the amaryllidaceae alkaloids. In recent years, pharmaceutical and organic chemists discovered that lycorine and their derivatives have anti-tumor, anti-inflammatory, inhibiting acetylcholinesterase, anti-malarial, cardiovascular protection and other effects. Because of its complex and unique molecular structure and extensive pharmaceutical activities, lycorine has attracted considerable research effort. The recent progresses in the synthesis and structural modification of lycorine are summarized in this review.

Key words: lycorine, total synthesis, derivatives, structure modification

Cite this article

Liu Yingjie, Ding Zeyang, Tan Chong, Yuan Hongliang, Ji Yubin. Progresses in the Total Synthesis and Structure Modification Studies of Lycorine[J]. Chin. J. Org. Chem., 2015, 35(5): 1009-1021.

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石蒜碱的全合成及结构修饰研究进展

Progresses in the Total Synthesis and Structure Modification Studies of Lycorine

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