"One-Pot" Synthesis of Ketones from the Reaction of Weinreb Amides and Halides Prompted by Magnesium Powder

doi:10.6023/cjoc201411014

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (5): 1046-1051.DOI: 10.6023/cjoc201411014 Previous Articles Next Articles

ARTICLE

镁粉促进Weinreb酰胺和卤代烃的“一锅法”制备酮类反应研究

王凤娇, 陆爱玲, 黄丹凤, 苏瀛鹏, 夏晓文, 徐艳丽, 王克虎, 胡雨来

西北师范大学化学化工学院兰州 730070

收稿日期:2014-11-10 修回日期:2014-12-11 发布日期:2015-01-09
通讯作者: 黄丹凤, 王克虎 E-mail:huangdf@nwnu.edu.cn;wangkh@nwnu.edu.cn
基金资助:
国家自然科学基金(No.21462037)资助项目.

"One-Pot" Synthesis of Ketones from the Reaction of Weinreb Amides and Halides Prompted by Magnesium Powder

Wang Fengjiao, Lu Ailing, Huang Danfeng, Su Yingpeng, Xia Xiaowen, Xü Yanli, Wang Ke-Hu, Hu Yulai

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Received:2014-11-10 Revised:2014-12-11 Published:2015-01-09
Supported by:
Project supported by the National Natural Science Foundation of China (No.21462037).

1. "One-Pot" Synthesis of Ketones from the Reaction of Weinreb Amides and Halides Prompted by Magnesium Powder.PDF(746KB)

Abstract

The “one-pot” reaction of Weinreb amides and halides promoted by magnesium powder was investigated under air atmosphere at room temperature. It was found that the Weinreb amides from monocarboxylic acid can react with halides to give corresponding ketones efficiently. Keto Weinreb amides or diketones can be obtained from the reaction of the Weinreb amides with halides under different reaction conditions. The method has the advantages of simple operation and high yields.

Key words: one-pot, Weinreb amides, keto Weinreb amides, diketones

Cite this article

Wang Fengjiao, Lu Ailing, Huang Danfeng, Su Yingpeng, Xia Xiaowen, Xü Yanli, Wang Ke-Hu, Hu Yulai. "One-Pot" Synthesis of Ketones from the Reaction of Weinreb Amides and Halides Prompted by Magnesium Powder[J]. Chin. J. Org. Chem., 2015, 35(5): 1046-1051.

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镁粉促进Weinreb酰胺和卤代烃的“一锅法”制备酮类反应研究

"One-Pot" Synthesis of Ketones from the Reaction of Weinreb Amides and Halides Prompted by Magnesium Powder

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