Combinatorial Synthesis of Flavonoids and 4-Hydroxy-δ-lactones by Plant-Originated Enzymes

doi:10.6023/cjoc201409042

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (5): 1052-1059.DOI: 10.6023/cjoc201409042 Previous Articles Next Articles

ARTICLE

植物酶催化组合合成黄酮及4-羟基-δ-内酯类化合物

莫婷^a,b, 王娟^a,b, 高博闻^a,b, 张乐^a,b, 刘晓^a, 王晓晖^a, 屠鹏飞^a, 史社坡^a

a 北京中医药大学中药现代研究中心北京 100029;
b 北京中医药大学中药学院北京 100102

收稿日期:2014-09-25 修回日期:2014-12-25 发布日期:2015-01-07
通讯作者: 屠鹏飞, 史社坡 E-mail:pengfeitu@163.com;shishepo@163.com
基金资助:
教育部新世纪优秀人才支持计划(No.NCET-11-0604)、北京市自然科学基金(No.5132022)、北京中医药大学自主选题(No.2014-JYBZZ-XS-091)资助项目.

Combinatorial Synthesis of Flavonoids and 4-Hydroxy-δ-lactones by Plant-Originated Enzymes

Mo Ting^a,b, Wang Juan^a,b, Gao Bowen^a,b, Zhang Le^a,b, Liu Xiao^a, Wang Xiaohui^a, Tu Pengfei^a, Shi Shepo^a

a Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029;
b School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing 100102

Received:2014-09-25 Revised:2014-12-25 Published:2015-01-07
Supported by:
Project supported by the Program for New Century Excellent Talents in University (No.NCET-11-0604), the Beijing Natural Science Foundation (No.5132022) and the Independent Subject of Beijing University of Chinese Medicine (No.2014-JYBZZ-XS-091).

1. Combinatorial Synthesis of Flavonoids and 4-Hydroxy-δ-lactones by Plant-Originated Enzymes.PDF(760KB)

Abstract

4-Coumarate coenzyme A ligase (4CL) and chalcone synthase (CHS), the two pivotal enzymes involved in the biosynthesis of flavonoids were applied to combinatorially synthesize varied unnatural natural products. As result, 25 unnatural natural products including eight flavonoid analogues, 16 4-hydroxy-δ-lactones and one benzalacetone were synthesized by 4CL and CHS. The synthetic methodology would be useful for the construction of library of structurally diverse of small molecules.

Key words: plant polyketide synthases, unnatural natural products, 4-coumarate coenzyme A ligase, flavonoids, 4-hydroxy-δ-lactones

Cite this article

Mo Ting, Wang Juan, Gao Bowen, Zhang Le, Liu Xiao, Wang Xiaohui, Tu Pengfei, Shi Shepo. Combinatorial Synthesis of Flavonoids and 4-Hydroxy-δ-lactones by Plant-Originated Enzymes[J]. Chin. J. Org. Chem., 2015, 35(5): 1052-1059.

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植物酶催化组合合成黄酮及4-羟基-δ-内酯类化合物

Combinatorial Synthesis of Flavonoids and 4-Hydroxy-δ-lactones by Plant-Originated Enzymes

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