Studies on Loading Doxorubicin and Coumarin by Medical Biocompatible Graft Copolymer

doi:10.6023/cjoc201509032

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (12): 2529-2536.DOI: 10.6023/cjoc201509032 Previous Articles Next Articles

Articles

医用生物相容性接枝共聚物负载阿霉素和香豆素的研究

钱文昊^a,b, 苏俭生^a, 龚雪^a, 叶茂^b, 徐培成^b

a 上海牙组织修复与再生工程技术研究中心同济大学口腔医学院口腔修复学教研室上海 200072;
b 上海市徐汇区牙病防治所上海 200032

收稿日期:2015-09-25 修回日期:2015-10-09 发布日期:2015-10-13
通讯作者: 苏俭生, 徐培成 E-mail:sjs@tongji.edu.cn;xpc1238@126.com
基金资助:
国家自然科学基金(Nos. 81371949, 81572114)和上海市生物医药科技重点(No. 13411951200)资助项目.

Studies on Loading Doxorubicin and Coumarin by Medical Biocompatible Graft Copolymer

Qian Wenhao^a,b, Su Jiansheng^a, Gong Xue^a, Ye Mao^b, Xu Peicheng^b

a Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Prosthodontics, School of Stomatology, Tongji University, Shanghai 200072;
b Department of Stomatology, Shanghai Xuhui District Dental Center, Shanghai 200032

Received:2015-09-25 Revised:2015-10-09 Published:2015-10-13
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 81371949 and 81572114) and the Shanghai Scientific Technological Innovation Project (No. 13411951200).

1. Studies on Loading Doxorubicin and Coumarin by Medical Biocompatible Graft Copolymer.PDF(372KB)

Abstract

The end of linear m-PEG-OH was functionalized to provide m-PEG-CTA macro-RAFT agent. RAFT homopolymerization of tBHBMA was conducted to give PEG-b-PtBHBMA diblock copolymer, which initiated ROP of lactide directly. The obtained graft copolymer, PEG-b-(PtBA-g-PLA), was then esterified with 7-methoxycoumarin-3- carboxylic acid to afford PEG-b-(PtBA-g-PLA-COU) containing fluorescent dye molecule. PEG-b-(PAA-g-PLA-COU) amphiphilic graft copolymer was prepared by selective hydrolysis of PtBA segment. Finally, doxorubicin (DOX) was loaded into polymeric micelles aggregated by PEG-b-(PAA-g-PLA-COU). The drug loading content (DLC) and size of the obtained polymeric drug micelles containing fluorescent dye molecule was measured by UV-vis and DLS.

Key words: graft copolymer, polymeric drug micelles, coumarin, doxorubicin

Cite this article

Qian Wenhao, Su Jiansheng, Gong Xue, Ye Mao, Xu Peicheng. Studies on Loading Doxorubicin and Coumarin by Medical Biocompatible Graft Copolymer[J]. Chin. J. Org. Chem., 2015, 35(12): 2529-2536.

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医用生物相容性接枝共聚物负载阿霉素和香豆素的研究

Studies on Loading Doxorubicin and Coumarin by Medical Biocompatible Graft Copolymer

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