Synthesis and Bioactivities of Novel Coumarin Derivatives Containing Sulfinic Esters or Sulfinamide Moiety

doi:10.6023/cjoc201601011

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (7): 1653-1661.DOI: 10.6023/cjoc201601011 Previous Articles Next Articles

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含亚磺酸酯或亚磺酰胺基团的香豆素衍生物的合成及生物活性研究

刘明^a, 刘阳^a, 刘艾林^b, 张冬凯^a, 陈明桂^a, 吴长春^a, 华学文^a, 周莎^a, 李正名^a

a. 南开大学元素有机化学研究所元素有机化学国家重点实验室天津化学化工协同创新中心天津 300071;
b. 北京协和医学院中国医学科学院药物研究所北京 100050

收稿日期:2016-01-11 修回日期:2016-02-22 发布日期:2016-03-11
通讯作者: 李正名 E-mail:nkzml@vip.163.com
基金资助:
高等学校学科创新引智计划（No.B06005）、元素有机化学国家重点实验室和天津化学化工协同创新中心资助项目.

Synthesis and Bioactivities of Novel Coumarin Derivatives Containing Sulfinic Esters or Sulfinamide Moiety

Liu Ming^a, Liu Yang^a, Liu Ailin^b, Zhang Dongkai^a, Chen Minggui^a, Wu Changchun^a, Hua Xuewen^a, Zhou Sha^a, Li Zhengming^a

a. State Key Laboratory of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
b. Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050

Received:2016-01-11 Revised:2016-02-22 Published:2016-03-11
Supported by:
Project supported by the “111” Project of Ministry of Education of China (No. B06005), and the State Key Laboratory of Elemento-organic Chemistry and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin).

1. Synthesis and Bioactivities of Novel Coumarin Derivatives Containing Sulfinic Esters or Sulfinamide Moiety.PDF(1318KB)

Abstract

A series of novel coumarin derivatives containing sulfinic esters or sulfonamide were designed and synthesized. Their structures were characterized by ¹H NMR, ¹³C NMR and elemental analysis. The preliminary bioassays indicated that several target compounds exhibited good in vitro antitumor activities on A549 (up to 67.82%), Bel7402 (up to 58.47%) and HCT-8 (up to 74.80%) at 5.0 mg/L and moderate antifungal activities on Physalospora piricola (up to 82.0 %) at 50 mg/L. The structure-activity relationship of these target compounds was discussed accordingly.

Key words: coumarin, sulfinic esters, sulfinamide, anticancer activity, antifungal activity

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Liu Ming, Liu Yang, Liu Ailin, Zhang Dongkai, Chen Minggui, Wu Changchun, Hua Xuewen, Zhou Sha, Li Zhengming. Synthesis and Bioactivities of Novel Coumarin Derivatives Containing Sulfinic Esters or Sulfinamide Moiety[J]. Chin. J. Org. Chem., 2016, 36(7): 1653-1661.

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含亚磺酸酯或亚磺酰胺基团的香豆素衍生物的合成及生物活性研究

Synthesis and Bioactivities of Novel Coumarin Derivatives Containing Sulfinic Esters or Sulfinamide Moiety

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