Facile Synthesis of (2-Amino-3-(benzothiazol-2-yl)-4H-chromen- 4-yl)phosphonate Derivatives under Mild Conditions

doi:10.6023/cjoc201512021

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (7): 1643-1652.DOI: 10.6023/cjoc201512021 Previous Articles Next Articles

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温和条件下[2-氨基-3-(苯并噻唑-2-基)-4H-色烯-4-基]膦酸酯衍生物的简便合成

颜浩浩, 赵博良, 高钰, 杜大明

北京理工大学化工与环境学院北京 100081

收稿日期:2015-12-15 修回日期:2016-01-22 发布日期:2016-03-11
通讯作者: 杜大明 E-mail:dudm@bit.edu.cn
基金资助:
国家自然科学基金（No.21272024）资助项目.

Facile Synthesis of (2-Amino-3-(benzothiazol-2-yl)-4H-chromen- 4-yl)phosphonate Derivatives under Mild Conditions

Yan Haohao, Zhao Boliang, Gao Yu, Du Daming

School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081

Received:2015-12-15 Revised:2016-01-22 Published:2016-03-11
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21272024).

1. Facile Synthesis of (2-Amino-3-(benzothiazol-2-yl)-4H-chromen- 4-yl)phosphonate Derivatives under Mild Conditions.PDF(1596KB)

Abstract

A series of (2-amino-3-(benzothiazol-2-yl)-4H-chromen-4-yl)phosphonate derivatives were synthesized in good to excellent yields by Michael addition/cyclization of diphenyl phosphite to diverse substituted(E)-2-(benzothiazol-2-yl)-3-(2-hydroxyphenyl)acrylonitriles under catalyst-free condition in water. Meanwhile, one-pot three component reaction of salicylaldehyde, 2-(benzothiazol-2-yl)acetonitrile and diphenyl phosphate was also tested using Et₃N as catalyst to synthesize these phosphonate derivatives

Key words: Michael addition, cyclization, phosphonate, chromene, heterocycle

Cite this article

Yan Haohao, Zhao Boliang, Gao Yu, Du Daming. Facile Synthesis of (2-Amino-3-(benzothiazol-2-yl)-4H-chromen- 4-yl)phosphonate Derivatives under Mild Conditions[J]. Chin. J. Org. Chem., 2016, 36(7): 1643-1652.

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温和条件下[2-氨基-3-(苯并噻唑-2-基)-4H-色烯-4-基]膦酸酯衍生物的简便合成

Facile Synthesis of (2-Amino-3-(benzothiazol-2-yl)-4H-chromen- 4-yl)phosphonate Derivatives under Mild Conditions

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