Recent Advances of Direct Incorporation of Fluorine-Containing Groups and 18F-Labeling Methods

doi:10.6023/cjoc201601009

Abstract

Fluorine-containing groups have strong electron-withdrawing effect and high lipophilicity, organic molecules incorporated fluorine-containing groups can improve its function. Therefore, the incorporation of fluorine-containing groups into molecules has become the current research hotspot. The method for incorporation of CF₃S group becomes one of the hot research field due to its excellent nature. The strategy for incorporation of CF₃Se, CF₃O and CF₃CH₂O groups has also been the attention of researchers. ¹⁸F has nearly ideal nuclear properties and is the most widely used positron emission tomography (PET) radioisotope for clinical imaging. Therefore, the development of new [¹⁸F]radiotracers becomes the research focus of many researchers. The method for ¹⁸F-labeling of biomolecules is the key to the development of new [¹⁸F]radiotracers. This paper mainly introduce the recently reported methodology of direct incorporating CF₃X (X＝S, Se, O, CH₂O) groups into molecules and some research results of ¹⁸F-labeling methods. Furthermore, some noteworthy research directions in this field are summarized.

Key words: trifluoromethylthiolation, trifluoromethylselenolation, trifluoromethyloxylation, trifluoroethoxylation, ¹⁸F-labeling

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Li Gongming, Sun Dequn. Recent Advances of Direct Incorporation of Fluorine-Containing Groups and ¹⁸F-Labeling Methods[J]. Chin. J. Org. Chem., 2016, 36(8): 1715-1740.

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分子内直接引入含氟基团以及¹⁸F-标记方法研究进展

Recent Advances of Direct Incorporation of Fluorine-Containing Groups and ¹⁸F-Labeling Methods

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分子内直接引入含氟基团以及18F-标记方法研究进展