Bromopalladation Triggering the Cascade Oxidative Heterocyclization Reaction of Alkynes with Alkenes in Ionic Liquids

doi:10.6023/cjoc201603043

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (9): 2136-2141.DOI: 10.6023/cjoc201603043 Previous Articles Next Articles

ARTICLE

离子液体中溴钯化启动的烯炔烃串联的氧化杂环化反应研究

安艳妮, 李建晓, 张振明, 李春生, 杨少容

华南理工大学化学与化工学院广州 510640

收稿日期:2016-03-27 修回日期:2016-04-14 发布日期:2016-05-17
通讯作者: 李建晓, 杨少容 E-mail:lisryang@scut.edu.cn
基金资助:
项目受国家自然科学基金（No.21502055），中央高校基本科研业务费（No.2015ZM150）和中国博士后科学基金（No.2015M572303）资助.

Bromopalladation Triggering the Cascade Oxidative Heterocyclization Reaction of Alkynes with Alkenes in Ionic Liquids

An Yanni, Li Jianxiao, Zhang Zhenming, Li Chunsheng, Yang Shaorong

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640

Received:2016-03-27 Revised:2016-04-14 Published:2016-05-17
Supported by:
Project supported by the National Natural Science Foundation of China (No.21502055), the Fundamental Research Funds for the Central Universities (No.2015ZM150) and China Postdoctoral Science Foundation (No.2015M572303).

1. Bromopalladation Triggering the Cascade Oxidative Heterocyclization Reaction of Alkynes with Alkenes in Ionic Liquids.PDF(695KB)

Abstract

An efficient and practical palladium-catalyzed cascade oxidative heterocyclization has been developed to afford functionalized oxygen-containing five-membered heterocycles in moderate to good yields with high regio- and diastereo-selectivities. Their structures were confirmed by IR, ¹H NMR, ¹³C NMR and HRMS. Furthermore, the current methodology could also be conveniently applied to the synthesis of naturally occurring biologically active functionalized tetrahydrofurans and γ-lactones frameworks.

Key words: palladium-catalyzed, ionic liquids, alkynes, alkenes, heterocycles

Cite this article

An Yanni, Li Jianxiao, Zhang Zhenming, Li Chunsheng, Yang Shaorong. Bromopalladation Triggering the Cascade Oxidative Heterocyclization Reaction of Alkynes with Alkenes in Ionic Liquids[J]. Chin. J. Org. Chem., 2016, 36(9): 2136-2141.

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离子液体中溴钯化启动的烯炔烃串联的氧化杂环化反应研究

Bromopalladation Triggering the Cascade Oxidative Heterocyclization Reaction of Alkynes with Alkenes in Ionic Liquids

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