Synthesis of Isoquinolines Derivatives from o-Alkynyl Aldehydes

doi:10.6023/cjoc201604031

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (10): 2504-2509.DOI: 10.6023/cjoc201604031 Previous Articles Next Articles

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基于邻炔基醛的异喹啉及其衍生物的合成研究

李余波, 赵云辉, 罗明检, 唐子龙, 曹朝暾, 邓克勤

湖南科技大学化学化工学院湖南科技大学理论化学与分子模拟省部共建教育部重点实验室分子构效关系湖南省普通高等学校重点实验室湘潭 411201

收稿日期:2016-04-14 修回日期:2016-05-20 发布日期:2016-06-02
通讯作者: 赵云辉,E-mail:zhao_yunhui@163.com;唐子龙,E-mail:zltang67@aliyun.com E-mail:zhao_yunhui@163.com;zltang67@aliyun.com
基金资助:
国家自然科学基金（Nos.21372070，21471052）和湖南省教育厅基金（No.14k035）资助项目.

Synthesis of Isoquinolines Derivatives from o-Alkynyl Aldehydes

Li Yubo, Zhao Yunhui, Luo Mingjian, Tang Zilong, Cao Chaotun, Deng Keqin

Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education of China, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201

Received:2016-04-14 Revised:2016-05-20 Published:2016-06-02
Supported by:
Project supported by the National Natural Science Foundation of China (Nos.21372070, 21471052), and the Hunan Provincial Education Office Scientific Research Foundation Project (No.14k035).

1. Synthesis of Isoquinolines Derivatives from o-Alkynyl Aldehydes.PDF(684KB)

Abstract

The isoquinoline and dihydroisoquinoline ring systems are found as the core nucleus in a wide variety of natural products and pharmaceutical agents with good biologically activity. Isoquinoline, benzoxazine-fused isoquinlines and pyrazo-lo[5,1-a]isoquinolines are prepared from o-alkynyl aldehydes and nitrogen-containing compounds via tandem reactions catalyzed by CuI or AgNO₃. The reactions have some advantages, such as mild reaction conditions, simple operation and easily available catalysts.

Key words: isoquinoline, benzoxazine-fused isoquinlines, pyrazolo[5,1-a]isoquinolines, o-alkynyl aldehydes, tandem reaction

Cite this article

Li Yubo, Zhao Yunhui, Luo Mingjian, Tang Zilong, Cao Chaotun, Deng Keqin. Synthesis of Isoquinolines Derivatives from o-Alkynyl Aldehydes[J]. Chin. J. Org. Chem., 2016, 36(10): 2504-2509.

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基于邻炔基醛的异喹啉及其衍生物的合成研究

Synthesis of Isoquinolines Derivatives from o-Alkynyl Aldehydes

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