A Concisely Convergent Synthesis of Berberine Chloride

doi:10.6023/cjoc201612005

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (2): 503-507.DOI: 10.6023/cjoc201612005 Previous Articles Next Articles

NOTE

盐酸黄连素的汇聚式合成研究

陈程^a, 徐蒙蒙^a, 赵青^b, 刘承秀^c, 杨鸿均^a, 冯豫川^a

a 西南民族大学化学与环境保护工程学院成都 610041;
b 西南民族大学预科教育学院成都 610041;
c 西南民族大学校医院成都 610041

收稿日期:2016-12-02 修回日期:2017-01-01 发布日期:2017-01-17
通讯作者: 杨鸿均, 冯豫川 E-mail:yanghj@swun.cn
基金资助:
西南民族大学研究生创新（No.CX2015SZ045）和四川省教育厅（No.15ZB0487）资助项目.

A Concisely Convergent Synthesis of Berberine Chloride

Chen Cheng^a, Xu Mengmeng^a, Zhao Qing^b, Liu Chengxiu^c, Yang Hongjun^a, Feng Yuchuan^a

a College of Chemistry & Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041;
b Preparatory School, Southwest University for Nationalities, Chengdu 610041;
c Southwest University for Nationalities Hospital, Chengdu 610041

Received:2016-12-02 Revised:2017-01-01 Published:2017-01-17
Supported by:
Project supported by the Graduate Innovative Research Projects of Central Universities, Southwest University for Nationalities (No. CX2015SZ045) and the Research Projects Sichuan Provincial Department of Education (No. 15ZB0487).

1. A Concisely Convergent Synthesis of Berberine Chloride.PDF(244KB)

Cite this article

Chen Cheng, Xu Mengmeng, Zhao Qing, Liu Chengxiu, Yang Hongjun, Feng Yuchuan. A Concisely Convergent Synthesis of Berberine Chloride[J]. Chin. J. Org. Chem., 2017, 37(2): 503-507.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

share this article

[1] (a) Lo, C. Y.; Hsu, L. C.; Chen, M. S.; Lin, Y. J.; Chen, L. G.; Kuo, C. D.; Wu., J. Y. Bioorg. Med. Chem. Lett. 2013, 23, 305.
(b) Li, Q.; Xiang, J. F.; Tang, Y. L. Chin. J. Chem. 2015, 33, 1041.
[2] Zhang, S. L.; Chang, J. J.; Damu, G. V.; Fang, B.; Zhou, X. D.; Geng, R. X.; Zhou, C. H. Bioorg. Med. Chem. Lett. 2013, 23, 1008.
[3] (a) Samosorn, S.; Tanwirat, B.; Muhamad, N.; Casadei, G.; Tomkiewicz, D.; Lewis, K.; Suksamrarn, A.; Prammananan, T.; Gornall, K. C.; Beck, J. L.; Bremner, J. B. Bioorg. Med. Chem. 2009, 17, 3866.
(b) Zhang, S. L.; Damu, G. L.; Zhang, L.; Geng, R. X.; Zhou, C. H. Eur. J. Med. Chem. 2012, 55, 164.
[4] Bodiwala, H. S.; Sabde, S.; Mitra, D.; Bhutani, K. K.; Singh, I. P. Eur. J. Med. Chem. 2011, 46, 1045.
[5] Vennerstrom, J. L.; Lovelace, J. K.; Wsits, V. B.; Hanson, W. L.; Klayman, D. L. Antimicrob. Agents Chemother. 1990, 34, 918.
[6] Bahar, M.; Deng, Y.; Zhu, X.; He, S.; Pandharkar, T.; Drew, M. E.; Navarro-Vazquez, A.; Anklin, C.; Gil, R. R.; Dos Kotch, R. W.; Werbovetz, K. A.; Kinghorn, A. D. Bioorg. Med. Chem. Lett. 2011, 21, 2606.
[7] (a) Letasiova, S.; Jantova, S.; Cipak, L.; Muckova, M. Cancer Lett. 2006, 239, 254.
(b) Ma, Y.; Ou, T. M.; Tan, J. H.; Hou, J. Q.; Huang, S. L.; Gu, L. Q.; Huang, Z. S. Bioorg. Med. Chem. Lett. 2009, 19, 3414.
[8] (a) Decker, V. I. Justus Liebigs Ann. Chem. 1913, 395, 295.
(b) Kametani, T.; Noguchi, l. J. Chem. Soc. (C) 1969, 2036.
(c) Nanning Pharmaceutical Chin. J. Pharm. 1973, (7), 1 (in Chinese).(广西南宁制药厂, 医药工业, 1973, (7), 1.)
(d) Masayuki, O.; Kumiko, Y.; Junko, O. Chem. Pharm. Bull. 1974, 22, 2365.
(e) Hangzhou First Pharmaceutical Reagent Chamber. Chin. J. Pharm. 1974, (8), 6 (in Chinese).(杭州第一制药厂试剂室, 医药工业, 1974, (8), 6.)
(f) North-east Pharmaceutical Factory Chin. J. Pharm. 1975, (4), 12 (in Chinese).(东北制药总厂, 医药工业, 1975, (4), 12.)
(g) Vinogradova, V. I.; Yunusov, M. S.; Kuchin, A. V.; Tolstikov, G. A.; Sagandykov, R. T.; Khaimuratov, K. A.; Ali mov, A. Chem. Nat. Compd. 1990, 26, 54.
(h) Hisashi, I.; Mayumi, O.; Shuji, O.; Takashi, H.; Tsutomu, I. Heterocycles 1994, 37, 897.
(i) Matulenko, M. A.; Meyers, A. I. J. Org. Chem. 1996, 61, 573.
(j) Yang, P.; Song, D. Q.; Li, Y. H.; Kong, W. J.; Wang, Y. X.; Gao, L. M.; Liu, S. Y.; Cao, R. Q.; Jiang, J. D. Bioorg. Med. Chem. Lett. 2008, 18, 4675.
(k) Gatland, A. E.; Pilgrim, B. S.; Procopiou, P. A.; Donohoe, T. J. Angew. Chem. Int. Ed. 2014, 53, 14555.
(l) He, Y.; Zheng, Y.; Hai, L.; Wu, Y. Chin. J. Chem. 2014, 32, 1121.
(m) Reddy, V.; Jadhav, A. S.; Vijaya Anand, R. Org. Biomol. Chem. 2015, 13, 3732.
(n) Chen, C.; Luo, Z. M.; Yang, H. J.; Feng, Y. C. Chin. J. Org. Chem. 2016, 36, 1426 (in Chinese).(陈程, 罗卓玛, 杨鸿均, 冯豫川, 有机化学, 2016, 36, 1426.)
[9] (a) Roy, S. C.; Guin, C.; Rana, K. K.; Maiti, G. Tetrahedron Lett. 2001, 42, 6941.
(b) Roy, S. C.; Guin, C.; Maiti, G. Tetrahedron Lett. 2001, 42, 9253.
[10] Tietze, L. F., Schirok, H. J. Am. Chem. Soc. 1999, 121, 10264.
[11] Pan, J. F.; Yu, C.; Zhu, D. Y.; Zhang, H.; Ren, J. Y. CN 1314347, 2001 [Chem. Abstr. 2002, 137, 370266].

盐酸黄连素的汇聚式合成研究

A Concisely Convergent Synthesis of Berberine Chloride

PDF

Supporting Info.

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 3

Recommended Articles

Metrics

Comments

[1]	Han Jilai, Tang Meilin, Sun Xun. Study on the Total Synthesis of Resveratrol Dimers Quadrangularin A and Pallidol [J]. Chinese Journal of Organic Chemistry, 2020, 40(6): 1571-1577.
[2]	Chen Cheng, Luo Zhuoma, Yang Hongjun, Feng Yuchuan. A Novel Synthetic Route for Berberine Chloride [J]. Chin. J. Org. Chem., 2016, 36(6): 1426-1430.
[3]	Gao Zhigang, Zhang Datong, Wei Peng, Wang Zhe, Xie Yafei, Liu Yuqiang, Xu Weiren, Tang Lida, Zhao Guilong. A Facile Convergent Synthetic Procedure for 3-Deoxydapagliflozin as SGLT2 Inhibitor [J]. Chin. J. Org. Chem., 2014, 34(9): 1829-1839.