Synthesis and Insecticidal Activity of o-Carboxamidobenzamide Compounds Containing 2-(Substituted phenyl)oxazole Group

doi:10.6023/cjoc201612030

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (7): 1774-1780.DOI: 10.6023/cjoc201612030 Previous Articles Next Articles

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含2-(取代苯基)噁唑基的邻甲酰胺基苯甲酰胺类化合物合成及杀虫活性研究

王梦梦, 张青青, 岳凯, 李庆山, 徐凤波

南开大学化学学院元素有机化学国家重点实验室天津 300071

收稿日期:2016-12-07 修回日期:2017-02-22 发布日期:2017-03-08
通讯作者: 李庆山 E-mail:qli@.nankai.edu.cn
基金资助:
国家自然科学基金（Nos.20772060，21172114）和南开大学元素有机化学国家重点实验室资助项目.

Synthesis and Insecticidal Activity of o-Carboxamidobenzamide Compounds Containing 2-(Substituted phenyl)oxazole Group

Wang Mengmeng, Zhang Qingqing, Yue Kai, Li Qingshan, Xu Fengbo

State Key Laboratory of Elemento-Organic Chemistry,College of Chemistry,NanKai University,TianJin 300071

Received:2016-12-07 Revised:2017-02-22 Published:2017-03-08
Contact: 10.6023/cjoc201612030 E-mail:qli@.nankai.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos.20772060,21172114) and the State Key Laboratory of Elemento-Organic Chemistry,Nankai University.

1. Synthesis and Insecticidal Activity of o-Carboxamidobenzamide Compounds Containing 2-(Substituted phenyl)oxazole Group.PDF(1624KB)

Abstract

In order to study the insecticidal activity of o-carboxamidobenzamide compounds, to investigate the structure-activity relationships of these compounds, 2-amino-3-hydroxypropionic acid and substituted 2-nitrobenzoic acid were used as starting materials to synthesize 29 diamides target compounds containing 2-substituted phenyloxazole groups, the yields were in the range of 30% and 50%. The insecticidal activities of these compounds were investigated. To some extend, the title compounds showed insecticidal activity against oriental armyworm (Mythimna separata Walker) in vitro. 2-(2-bromophenyl)-N-(4-chloro-2-(methoxy carbamoyl)-6-methyl phenyl) oxazole-4-carbox-amide (compound 11p) showed the highest insecticidal activity among these compounds. The structure-activity relationship of these compounds was summarized and the compounds with high activity were obtained.

Key words: insecticide, o-carboxamidobenzamide compounds, benzoxazole compounds

Cite this article

Wang Mengmeng, Zhang Qingqing, Yue Kai, Li Qingshan, Xu Fengbo. Synthesis and Insecticidal Activity of o-Carboxamidobenzamide Compounds Containing 2-(Substituted phenyl)oxazole Group[J]. Chin. J. Org. Chem., 2017, 37(7): 1774-1780.

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含2-(取代苯基)噁唑基的邻甲酰胺基苯甲酰胺类化合物合成及杀虫活性研究

Synthesis and Insecticidal Activity of o-Carboxamidobenzamide Compounds Containing 2-(Substituted phenyl)oxazole Group

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