Tin-Promoted One-Pot Synthesis of Aryl/Trifluoromethyl Group Substituted Homoallylic N-Acylhydrazines

doi:10.6023/cjoc201612042

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (7): 1764-1773.DOI: 10.6023/cjoc201612042 Previous Articles Next Articles

Articles

锡粉促进“一锅法”合成芳基三氟甲基取代高烯丙基酰肼类化合物

王克虎, 王雅琳, 殷雪娇, 彭先沙, 黄丹凤, 苏瀛鹏, 胡雨来

西北师范大学化学化工学院兰州 730070

收稿日期:2016-12-13 修回日期:2017-03-01 发布日期:2017-03-14
通讯作者: 王克虎, 胡雨来 E-mail:wangkh@nwnu.edu.cn;huyl@nwnu.edu.cn
基金资助:
国家自然科学基金（Nos.21262031，21462037）资助项目.

Tin-Promoted One-Pot Synthesis of Aryl/Trifluoromethyl Group Substituted Homoallylic N-Acylhydrazines

Wang Kehu, Wang Yalin, Yin Xuejiao, Peng Xiansha, Huang Danfeng, Su Yingpeng, Hu Yulai

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Received:2016-12-13 Revised:2017-03-01 Published:2017-03-14
Contact: 10.6023/cjoc201612042 E-mail:wangkh@nwnu.edu.cn;huyl@nwnu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos.21262031,21462037).

1. Tin-Promoted One-Pot Synthesis of Aryl/Trifluoromethyl Group Substituted Homoallylic N-Acylhydrazines.PDF(10672KB)

Abstract

A series of trifluoromethylated homoallylic N-acylhydrazines were obtained from one-pot reaction of aryl trifluoroketones, acylhydrazines and allyl bromide promoted by tin powder in the presence of boron trifluoride diethyl etherate (BF₃·OEt₂). The features of this process include good yields, wide substrate scope, mild conditions and easy operation. Trifluoromethylated homoallylic N-acylhydrazines are useful trifluoromethyl building blocks. They can be easily transformed into trifluoromethylated nitrogen-containing compounds.

Key words: one-pot, tin powder, aryl trifluoroketones, trifluoromethylated homoallylic N-acylhydrazines

Cite this article

Wang Kehu, Wang Yalin, Yin Xuejiao, Peng Xiansha, Huang Danfeng, Su Yingpeng, Hu Yulai. Tin-Promoted One-Pot Synthesis of Aryl/Trifluoromethyl Group Substituted Homoallylic N-Acylhydrazines[J]. Chin. J. Org. Chem., 2017, 37(7): 1764-1773.

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锡粉促进“一锅法”合成芳基三氟甲基取代高烯丙基酰肼类化合物

Tin-Promoted One-Pot Synthesis of Aryl/Trifluoromethyl Group Substituted Homoallylic N-Acylhydrazines

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