I2/CuI-Mediated Oxidative Cyclization of Enamides to Polysubstituted Oxazoles

doi:10.6023/cjoc201708009

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (1): 215-220.DOI: 10.6023/cjoc201708009 Previous Articles Next Articles

Special Issue: 庆祝吴养洁院士九十华诞专辑；元素有机化学合辑2018-2019

Articles

碘/碘化亚铜介导的烯酰胺氧化环化反应合成多取代噁唑

于文全, 常俊标

郑州大学化学与分子工程学院郑州 450001

收稿日期:2017-08-06 修回日期:2017-08-31 发布日期:2017-09-15
通讯作者: 常俊标 E-mail:changjunbiao@zzu.edu.cn
基金资助:
郑州大学优秀青年人才研究基金（No.1521316004）和国家自然科学基金（No.81330075）资助项目.

I₂/CuI-Mediated Oxidative Cyclization of Enamides to Polysubstituted Oxazoles

Yu Wenquan, Chang Junbiao

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001

Received:2017-08-06 Revised:2017-08-31 Published:2017-09-15
Contact: 10.6023/cjoc201708009 E-mail:changjunbiao@zzu.edu.cn
Supported by:
Project supported by the Outstanding Young Talent Research Fund of Zhengzhou University (No. 1521316004) and the National Natural Science Foundation of China (No. 81330075).

1. I₂/CuI-Mediated Oxidative Cyclization of Enamides to Polysubstituted Oxazoles.PDF(1970KB)

Abstract

A concise and efficient iodine/copper(I) iodide-mediated intramolecular oxidative C—O bond formation reaction has been developed for oxazole synthesis. Under the optimal reaction conditions, oxidative cyclization of readily accessible enamide substrates provides facile access to a variety of oxazole derivatives bearing aryl, alkyl, amide, ester, and acyl substituents.

Key words: iodine, copper(I) iodide, oxidative cyclization, enamides, oxazoles

Cite this article

Yu Wenquan, Chang Junbiao. I₂/CuI-Mediated Oxidative Cyclization of Enamides to Polysubstituted Oxazoles[J]. Chin. J. Org. Chem., 2018, 38(1): 215-220.

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碘/碘化亚铜介导的烯酰胺氧化环化反应合成多取代噁唑

I₂/CuI-Mediated Oxidative Cyclization of Enamides to Polysubstituted Oxazoles

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