Buchwald-Hartwig Amination of Aryl Chlorides Catalyzed by Trinuclear N-Heterocyclic Carbene-Palladium(Ⅱ) Complexes

doi:10.6023/cjoc201708036

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (1): 259-265.DOI: 10.6023/cjoc201708036 Previous Articles Next Articles

Special Issue: 庆祝吴养洁院士九十华诞专辑

Notes

三核N-杂环卡宾-钯(II)化合物催化芳基氯化物的Buchwald-Hartwig胺化反应研究

王涛, 许凯, 张安安, 王万里, 刘澜涛

商丘师范学院化学化工学院药物绿色合成河南省工程实验室商丘 476000;商丘师范学院化学化工学院河南省生物分子识别与传感重点实验室商丘 476000

收稿日期:2017-08-18 修回日期:2017-10-05 发布日期:2017-10-16
通讯作者: 王涛, 刘澜涛 E-mail:wt67751726@126.com;liult05@iccas.ac.cn
基金资助:
国家自然科学基金（Nos.U1404205，21572126，21202095）、河南省高校科技创新人才计划（No.14HASTIT016）和河南省重点科技攻关（No.152102410056）资助项目.

Buchwald-Hartwig Amination of Aryl Chlorides Catalyzed by Trinuclear N-Heterocyclic Carbene-Palladium(Ⅱ) Complexes

Wang Tao, Xu Kai, Zhang An'an, Wang Wanli, Liu Lantao

Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000;Henan Key Laboratory of Biomolecular Recognition and Sensing, School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000

Received:2017-08-18 Revised:2017-10-05 Published:2017-10-16
Contact: 10.6023/cjoc201708036 E-mail:wt67751726@126.com;liult05@iccas.ac.cn
Supported by:
Project supported by the National Natural Sciences Foundation of China (Nos. U1404205, 21572126 and 21202095), the Program for Science & Technology Innovation Talents in Universities of Henan Province (No. 14HASTIT016), Innovation Scientists and Technicians Troop Construction Projects of Henan Province, and Key Scientific and Technological Project of Henan Province (152102410056).

1. Buchwald-Hartwig Amination of Aryl Chlorides Catalyzed by Trinuclear N-Heterocyclic Carbene-Palladium(Ⅱ) Complexes.PDF(7857KB)

Abstract

The trinuclear N-heterocyclic carbene-palladium(Ⅱ) complexes were found to be the effective catalyst precursors for the Buchwald-Hartwig amination of aryl chlorides. With catalyst loading of 2.0 mol%, the amination of secondary and primary amines with a variety of electronically and structurally diverse aryl chlorides gave the desired products in moderate to excellent yields within hours.

Key words: N-heterocyclic carbene, trinuclear palladium complexes, Buchwald-Hartwig amination, aryl chlorides

Cite this article

Wang Tao, Xu Kai, Zhang An'an, Wang Wanli, Liu Lantao. Buchwald-Hartwig Amination of Aryl Chlorides Catalyzed by Trinuclear N-Heterocyclic Carbene-Palladium(Ⅱ) Complexes[J]. Chin. J. Org. Chem., 2018, 38(1): 259-265.

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三核N-杂环卡宾-钯(II)化合物催化芳基氯化物的Buchwald-Hartwig胺化反应研究

Buchwald-Hartwig Amination of Aryl Chlorides Catalyzed by Trinuclear N-Heterocyclic Carbene-Palladium(Ⅱ) Complexes

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