Triphenylphosphine Mediated Direct Trifluoromethylthiolation of Indolizine and Pyrrole by Trifluoromethanesulfonyl Chloride

doi:10.6023/cjoc201706038

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (3): 677-683.DOI: 10.6023/cjoc201706038 Previous Articles Next Articles

Special Issue: 元素有机化学合辑2018-2019

Articles

三苯基膦参与的三氟甲烷磺酰氯对吲哚嗪和吡咯的直接三氟甲硫基化反应

赵霞^a, 李天娇^a, 田苗苗^a, 苏志扬^a, 魏奥琪^a, 芦逵^b

a 天津师范大学化学学院天津市功能分子结构与性能重点实验室无机-有机杂化功能材料化学教育部重点实验室天津 300387;
b 天津科技大学食品营养与安全和药物化学国际科技合作基地天津 300457

收稿日期:2017-06-28 修回日期:2017-09-30 发布日期:2017-11-15
通讯作者: 赵霞,E-mail:hxxyzhx@mail.tjnu.edu.cn E-mail:hxxyzhx@mail.tjnu.edu.cn
基金资助:
国家自然科学基金（No.21572158）资助项目.

Triphenylphosphine Mediated Direct Trifluoromethylthiolation of Indolizine and Pyrrole by Trifluoromethanesulfonyl Chloride

Zhao Xia^a, Li Tianjiao^a, Tian Miaomiao^a, Su Zhiyang^a, Wei Aoqi^a, Lu Kui^b

a Tianjin Key Laboratory of Structure and Performance for Functional Molecules, Key laboratory of Inorganic-organic Hybrid Functional Material Chemistry, Ministry of Education, College of Chemistry, Tianjin Normal University, Tianjin 300387;
b China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, Tianjin University of Science & Technology, Tianjin 300457

Received:2017-06-28 Revised:2017-09-30 Published:2017-11-15
Contact: 10.6023/cjoc201706038 E-mail:hxxyzhx@mail.tjnu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21572158).

1. Triphenylphosphine Mediated Direct Trifluoromethylthiolation of Indolizine and Pyrrole by Trifluoromethanesulfonyl Chloride.PDF(6199KB)

Abstract

A triphenylphosphine mediated direct trifluoromethylthiolation of indolizine and pyrrole by trifluoromethanesulfonyl chloride was developed. The readily accessable reagents and transition metal-free reaction conditions allowed this protocol applicable for large scales synthesis.

Key words: trifluoromethylthiolation, indolizine, pyrrole, trifluoromethanesulfonyl chloride, triphenylphosphine

Cite this article

Zhao Xia, Li Tianjiao, Tian Miaomiao, Su Zhiyang, Wei Aoqi, Lu Kui. Triphenylphosphine Mediated Direct Trifluoromethylthiolation of Indolizine and Pyrrole by Trifluoromethanesulfonyl Chloride[J]. Chin. J. Org. Chem., 2018, 38(3): 677-683.

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三苯基膦参与的三氟甲烷磺酰氯对吲哚嗪和吡咯的直接三氟甲硫基化反应

Triphenylphosphine Mediated Direct Trifluoromethylthiolation of Indolizine and Pyrrole by Trifluoromethanesulfonyl Chloride

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