Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (6): 1341-1349.DOI: 10.6023/cjoc201801037 Previous Articles     Next Articles

Reviews

过渡金属催化的成胍反应高效构建胍类衍生物

王连军a,b, 迟樾b, 张文雄b, 席振峰b   

  1. a 湖南工程学院化学化工学院 湘潭 411104;
    b 北京大学化学与分子工程学院 北京 100871
  • 收稿日期:2018-01-26 修回日期:2018-02-14 发布日期:2018-02-28
  • 通讯作者: 张文雄,E-mail:wx_zhang@pku.edu.cn E-mail:wx_zhang@pku.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21725201,21572005)资助项目.

Transition-Metal-Catalyzed Guanylation Reaction of Amines with Carbodiimides Constructing Guanidines

Wang Lianjuna,b, Chi Yueb, Zhang Wenxiongb, Xi Zhenfengb   

  1. a School of Chemistry and Chemical Engineering, Hunan Institute of Engineering, Xiangtan 411104;
    b College of Chemistry and Molecular Engineering, Peking University, Beijing 100871
  • Received:2018-01-26 Revised:2018-02-14 Published:2018-02-28
  • Contact: 10.6023/cjoc201801037 E-mail:wx_zhang@pku.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21725201, 21572005).

Guanidine derivatives are an important class of nitrogen-containing organic compounds, which are widely used in various pharmaceuticals, agrochemicals, sweeteners, explosives, and so on. Although classical methods for the synthesis of guanidines are established, there are still many fatal shortcomings which need to be resolved. In recent years, it has been gradually turned to the direct catalytic guanylation reaction of amines with carbodiimides. In this paper, the recent progress in transition-metal-catalyzed guanylation reaction of amines with carbodiimides to construct acyclic or cyclic guanidines based on the catalytic reaction mechanism, reaction system, the scope of substrates, etc. is reviewed.

Key words: guanylation reaction, guanidines, amines, carbodiimides