Synthesis of 2-Aminothiophene Derivatives Catalyzed by Amano Lipase M from Mucor javanicus

doi:10.6023/cjoc201801047

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (7): 1837-1841.DOI: 10.6023/cjoc201801047 Previous Articles Next Articles

Notes

爪哇毛霉脂肪酶催化合成2-氨基噻吩衍生物

卢粤, 姜国芳, 谢宗波, 陈国庆, 乐长高

东华理工大学应用化学系南昌 330013

收稿日期:2018-01-30 修回日期:2018-03-17 发布日期:2018-04-04
通讯作者: 姜国芳, 乐长高 E-mail:zhgle@ecit.cn;zbxie@ecit.cn
基金资助:
国家自然科学基金（Nos.21462001，21262002，21465002）、江西省科技计划（No.20161BCB24006）、江西省教育厅科技（Nos.KJLD14050，GJJ150584）资助项目.

Synthesis of 2-Aminothiophene Derivatives Catalyzed by Amano Lipase M from Mucor javanicus

Lu Yue, Jiang Guofang, Xie Zongbo, Chen Guoqing, Le Zhanggao

Department of Applied Chemistry, East China University of Technology, Nanchang 330013

Received:2018-01-30 Revised:2018-03-17 Published:2018-04-04
Contact: 10.6023/cjoc201801047 E-mail:zhgle@ecit.cn;zbxie@ecit.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21462001, 21262002, 21465002), the Science and Technology Projects of Jiangxi Province (No. 20161BCB24006), the Science and Technology Foundation of the Jiangxi Provincial Education Department (Nos. KJLD14050, GJJ150584).

1. Synthesis of 2-Aminothiophene Derivatives Catalyzed by Amano Lipase M from Mucor javanicus.PDF(15209KB)

Abstract

A series of 2-aminothiophene derivatives were synthesized by the Gewald reaction between α-active methylene nitrilthes and 2,5-dihydroxy-1,4-dithiane using amano lipase M from Mucor javanicus as biocatalyst. The method has the advantages of mild reaction conditions, biodegradability of catalyst and wide range of substrates compared with traditional catalysts.

Key words: α-active methylene nitrile, 2,5-dihydroxy-1,4-dithiane, lipase, Gewald reaction, 2-aminothiophene

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Lu Yue, Jiang Guofang, Xie Zongbo, Chen Guoqing, Le Zhanggao. Synthesis of 2-Aminothiophene Derivatives Catalyzed by Amano Lipase M from Mucor javanicus[J]. Chin. J. Org. Chem., 2018, 38(7): 1837-1841.

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爪哇毛霉脂肪酶催化合成2-氨基噻吩衍生物

Synthesis of 2-Aminothiophene Derivatives Catalyzed by Amano Lipase M from Mucor javanicus

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